Patents by Inventor Sami S. Zoghbi

Sami S. Zoghbi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiotracers for imaging P-glycoprotein function
    Patent number: 7989630
    Abstract: P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: August 2, 2011
    Assignee: National Institutes of Health Represented by the Secretary of the Department of Health and Human Services, National Institutes of Health
    Inventors: Victor W. Pike, Robert B. Innis, Sami S. Zoghbi, Neva Lazarova
  • RADIOTRACERS FOR IMAGING P-GLYCOPROTEIN FUNCTION
    Publication number: 20090274624
    Abstract: P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide.
    Type: Application
    Filed: April 30, 2008
    Publication date: November 5, 2009
    Inventors: Victor W. Pike, Robert B. Innis, Sami S. Zoghbi, Neva Lazarova