Patents by Inventor Samir Ross
Samir Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7767655Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipients. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.Type: GrantFiled: January 12, 2007Date of Patent: August 3, 2010Assignee: University of MississippiInventors: David Stanley Pasco, Nirmal Derek Pugh, Mahmoud Elsohly, Samir Ross
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Publication number: 20070286914Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.Type: ApplicationFiled: January 12, 2007Publication date: December 13, 2007Applicant: The University of MississippiInventors: David Pasco, Nirmal Pugh, Mahmoud Elsohly, Samir Ross
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Publication number: 20070264271Abstract: Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.Type: ApplicationFiled: April 5, 2007Publication date: November 15, 2007Applicant: The University of MississippiInventors: Mahmoud ElSohly, Samir Ross, David Pasco, Nirmal Pugh, Hala ElSohly
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Patent number: 7205284Abstract: Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.Type: GrantFiled: July 10, 2001Date of Patent: April 17, 2007Assignee: University of MississippiInventors: David Stanley Pasco, Nirmal Derek Pugh, Mahmoud ElSohly, Samir Ross, Nala Miazi ElSohly
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Patent number: 7196072Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.Type: GrantFiled: July 9, 2001Date of Patent: March 27, 2007Assignee: University of MississippiInventors: David Stanley Pasco, Nirmal Derek Ceri Pugh, Mahmoud ElSohly, Samir Ross
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Publication number: 20070059317Abstract: Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.Type: ApplicationFiled: July 10, 2001Publication date: March 15, 2007Inventors: Mahmoud ElSohly, Samir Ross, David Pasco, Nirmal Pugh, Hala ElSohly
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Patent number: 7098242Abstract: This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer, and protozoal infections, including malaria, or leishmaniasis. The compounds of this invention represent a potential new class of anti-tumor agents, one that has shown promising activity against solid tumors, and with a pattern of selectivity that suggests a possible new mechanism of action.Type: GrantFiled: July 21, 2004Date of Patent: August 29, 2006Assignee: The University of MississippiInventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
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Publication number: 20040266860Abstract: This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer, and protozoal infections, including malaria, or leishmaniasis.Type: ApplicationFiled: July 21, 2004Publication date: December 30, 2004Inventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
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Publication number: 20040229938Abstract: This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer, and protozoal infections, including malaria, or leishmaniasis.Type: ApplicationFiled: June 21, 2004Publication date: November 18, 2004Inventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
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Patent number: 6790863Abstract: This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer, and protozoal infections, including malaria, or leishmaniasis. The compounds of this invention represent a potential new class of anti-tumor agents, one that has shown promising activity against solid tumors, and with a pattern of selectivity that suggests a possible new mechanism of action.Type: GrantFiled: October 15, 2002Date of Patent: September 14, 2004Assignee: University of MississippiInventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
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Patent number: 6730519Abstract: A method for the isolation of delta-9-tetrahydrocannibinol (THC) from, Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained including the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid support from cannabis extracts rich in the acid washing of non-acid components of the extract with organic solvents and eluting of the delta-9-THC acid with strong polar solvents.Type: GrantFiled: December 4, 2001Date of Patent: May 4, 2004Assignee: The University of MississippiInventors: Mahmoud A. Elsohly, Samir A. Ross
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Publication number: 20040072896Abstract: This invention relates to a compound of the formula 1Type: ApplicationFiled: October 15, 2002Publication date: April 15, 2004Inventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
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Publication number: 20040038931Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.Type: ApplicationFiled: August 13, 2003Publication date: February 26, 2004Inventors: Mahmoud Elsobly, Samir Ross, David Stanley Pasco, Nirmal Derek Pugh
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Publication number: 20020086438Abstract: A method for the isolation of delta-9-tetrahydrocannibinol (THC) from, Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained comprising the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid support from cannabis extracts rich in the acid washing of non-acid components of the extract with organic solvents and eluting of the delta-9-THC acid with strong polar solvents.Type: ApplicationFiled: December 4, 2001Publication date: July 4, 2002Inventors: Mahmoud A. Elsohly, Samir A. Ross
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Publication number: 20020039795Abstract: A method of preparing tetrahydrocannabinol using extraction of plant material with a non-polar solvent followed by vacuum distillation and collection of a constant boiling fraction. Additional distillation steps and chromatographic steps, including HPLC reversed phase HPLC and flash chromatography, may be performed.Type: ApplicationFiled: October 26, 1998Publication date: April 4, 2002Applicant: Elsohly Et AlInventors: MAHMOUD A. ELSOHLY, SAMIR A. ROSS
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Patent number: 6365416Abstract: A method of preparing THC using extraction of plant material with a non-polar solvent followed by vacuum distillation and chromatography.Type: GrantFiled: October 26, 1998Date of Patent: April 2, 2002Assignee: The University of MississippiInventors: Mahmoud A. Elsohly, Samir A. Ross
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Patent number: 6008383Abstract: The present invention provides an economical and efficient process for converting delta-9-tetrahydrocannabinol to a variety of ester analogs. Delta-9-tetrahydrocannabinol is esterified by reaction with a carboxylic acid, an acid halide or an acid anhydride in the presence of a 4-aminopyridine either alone or in admixture with an organic amine such as a mono-, di-, or tri-alkyl amine.Type: GrantFiled: October 26, 1998Date of Patent: December 28, 1999Assignee: University of MississippiInventors: Mahmoud A. Elsohly, Samir A. Ross, Shixia Feng