Abstract: The present disclosure relates to an HCR lateral flow device for amplified detection of a target in a sample and methods of using the same. In some embodiments, the device and methods of use combine the sensitivity of HCR signal amplification with the simplicity of the lateral flow assay format to facilitate user-friendly amplified detection of a target in a sample.

Abstract: A method and system of training a spoken language understanding (SLU) model includes receiving natural language training data comprising (i) one or more speech recording, and (ii) a set of semantic entities and/or intents for each corresponding speech recording. For each speech recording, one or more entity labels and corresponding values, and one or more intent labels are extracted from the corresponding semantic entities and/or overall intent. A spoken language understanding (SLU) model is trained based upon the one or more entity labels and corresponding values, and one or more intent labels of the corresponding speech recordings without a need for a transcript of the corresponding speech recording.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. This disclosure also provides novel AAV capsid mutants. TRADE technology was used to identify novel AAV vectors that mediate neuronal transduction in the brain following intravenous administration. Application of TRADE in vivo resulted in the identification of new AAV capsids that can transduce neurons more efficiently and more specifically than AAV9 in the brain following administration of the new AAV capsids. The disclosed methods may be used to identify AAV capsids that target various cell populations.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.

Abstract: Provided are compositions comprising a gloss agent having a refractive index of 1.4 or greater, an emollient film facilitator having a viscosity of 300 cPs or greater, and a film-forming polymer, wherein the composition comprises a greater amount, on a weight percent basis, of emollient film facilitator than gloss agent. Also provided are methods of providing radiance to the skin by applying to the skin a composition of the present invention.

Abstract: A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.

Abstract: A foaming cleansing preparation and system that produce a high quality, self-sustaining foam immediately upon exposure to water without physical agitation or rubbing is provided. The inventive cleansing preparation is made up of at least one dry acid, at least one dry base, and at least one liquid film-forming cleansing agent. When the cleansing preparation is exposed to water, the acid(s) and the base(s) will react to form a gas and the cleansing agent(s) will form a liquid film, and the gas and the liquid film will then interact to form or generate a foam. The inventive cleansing system is made up of a plurality of delivery particles, with each such delivery particle containing one or more components of the inventive cleansing preparation.

Abstract: A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.

Abstract: Polyamides, polyesters, and polyamideesters are efficiently synthesized in a microwave process with precise temperature control. Compared to conventional thermal polymerizations, the microwave process takes less time and produces polymers with equivalent or superior physical properties.

Abstract: A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.