Patents by Inventor Samuel J. Asirvatham

Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170079822
    Abstract: Obesity treatment apparatus and methods are described herein involving gastric recycling of food are described herein. In one or more embodiments, the gastric recycling apparatus keeps returning chyme to the stomach increasing satiety signals and delaying hunger signals associated with an empty stomach. It may also may slow the emptying of the stomach as the caloric load in the stomach delays emptying and/or limit absorption of food within the small intestine by delivering at least a portion of food passing through the small intestine back into the stomach.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: Gianrico Farrugia, Paul A. Friedman, Elizabeth Rajan, Charles J. Bruce, Samuel J. Asirvatham, Michael J. Levy, Louis-Michel Wong Kee Song, Juliane Bingener-Casey, Navtej S. Buttar
  • Patent number: 9585708
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 7, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20170056104
    Abstract: Devices and methods are provided that can enhance the efficacy of medical treatments that cause hemodynamic effects. For example, this document provides devices and methods for enhancing the efficacy of medical treatments such as renal denervation and embolic protection procedures.
    Type: Application
    Filed: March 6, 2015
    Publication date: March 2, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Amir Lerman
  • Publication number: 20170056648
    Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.
    Type: Application
    Filed: March 20, 2015
    Publication date: March 2, 2017
    Applicants: Mayo Foundation for Medical Education and Research, St. Anne's University Hospital Brno
    Inventors: Faisal F. Syed, Charles J. Bruce, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham, Tomas Kara, Pavel Leinveber, Miroslav Novak, Zdenek Starek, Jiri Wolf
  • Publication number: 20160374754
    Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 29, 2016
    Inventors: Samuel J. Asirvatham, David R. Holmes, Jr.
  • Publication number: 20160361555
    Abstract: A multi-vector patient electrode system and method of use are disclosed.
    Type: Application
    Filed: June 10, 2015
    Publication date: December 15, 2016
    Inventors: Walter T. Savage M.D., Shelley J. Savage, Douglas M. Raymond, Peter D. Gray, Paul A. Friedman M.D., Samuel J. Asirvatham M.D., Charles J. Bruce M.D., Christopher V. DeSimone M.D.
  • Publication number: 20160361533
    Abstract: A multi-vector patient contact interface and method of use are disclosed.
    Type: Application
    Filed: June 10, 2015
    Publication date: December 15, 2016
    Inventors: Walter T. Savage, Shelley J. Savage, Douglas M. Raymond, Peter D. Gray, Paul A. Friedman, Samuel J. Asirvatham, Charles J. Bruce, Christopher V. DeSimone
  • Publication number: 20160287329
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 6, 2016
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20160256063
    Abstract: This document describes, among other things, a computer-implemented method that includes accessing, by a computer system, electrogram data for a patient, wherein the electrogram data is obtained using one or more leads that sense physiological electrical activity of the patient. The computer system can identify one or more waveform features from the electrogram data, and one or more correlations between values of the one or more waveform features and analyte levels. One or more estimated analyte levels in the patient are determined based on 1) the one or more waveform features identified from the electrogram data and 2) the one or more correlations. The computer system can output information related to the one or more estimated analyte levels.
    Type: Application
    Filed: September 26, 2014
    Publication date: September 8, 2016
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Kevin E. Bennet, Charles J. Bruce, Virend K. Somers, Samuel J. Asirvatham, Michael J. Ackerman, John J. Dillon, Dan Sadot, Yehu Sapir, Amir Geva
  • Patent number: 9414762
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 16, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
  • Patent number: 9392971
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: July 19, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20160151105
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20160074043
    Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 17, 2016
    Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM, TREVOR A. MCCAW, ELLIOT Y.K. HONG
  • Patent number: 9271786
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: March 1, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20160051322
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: April 15, 2014
    Publication date: February 25, 2016
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20160015294
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Application
    Filed: September 28, 2015
    Publication date: January 21, 2016
    Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM, TREVOR A. MCCAW, ELLIOT Y.K. HONG
  • Publication number: 20160015410
    Abstract: This document relates to devices and methods for the treatment of heart conditions. For example, this document relates to devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 21, 2016
    Inventors: Samuel J. Asirvatham, Barry A. Borlaug, Vojtech Melenovsky
  • Patent number: 9198683
    Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: December 1, 2015
    Assignees: AEGIS MEDICAL INNOVATIONS, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
  • Publication number: 20150297398
    Abstract: This document provides methods and materials involved in disrupting electrical activity in the stomach. For example, methods and materials involved in delivering one or more electrical shocks to the stomach (e.g., the muscularis propria) in a manner that disrupts the normal electrical activity of the stomach (e.g., defibrillating the stomach) are provided.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 22, 2015
    Inventors: Gianrico Farrugia, Navtej S. Buttar, Charles J. Bruce, Samuel J. Asirvatham, Elizabeth Rajan, Louis-Michel Wong Kee Song, Paul A. Friedman, Juliane Bingener-Casey, Michael J. Levy
  • Patent number: 9144431
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: September 29, 2015
    Assignees: AEGIS MEDICAL INNOVATIONS INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong