Patents by Inventor Samuel J. Asirvatham

Patent number: 8812099
Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
Type: Grant
Filed: November 16, 2012
Issued: August 19, 2014
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes
Patent number: 8790338
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Grant
Filed: February 13, 2012
Issued: July 29, 2014
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
Application number: 20140058282
Abstract: A gastro-electrical activity mapping system and method may comprise a catheter insertable through a natural orifice into the gastro-intestinal (GI) tract and comprising an array of electrodes for contacting an interior surface of a section of the GI tract to detect electrical potentials at multiple electrodes, and comprises a signal analysis and mapping system arranged to receive and process electrical signals from multiple electrodes of the array and spatially map GI smooth muscle electrical activity as an activation time map, a velocity map, or an amplitude map, which may be in the form of contour plots and may be mapped on an anatomical computer model of at least the section of the GI tract and may be animated.
Type: Application
Filed: October 18, 2011
Issued: February 27, 2014
Assignees: Mayo Foundation for Medical Education and Research, Auckland Uniservices Limited
Inventors: Gregory B. O'Grady, Leo K. Cheng, Andrew J. Pullan, Peng Du, Nira Paskaranandavadivel, Timothy R. Angeli, Gianrico Farrugia, Samuel J. Asirvatham
Patent number: 8538501
Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
Type: Grant
Filed: January 9, 2009
Issued: September 17, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
Patent number: 8409192
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Grant
Filed: February 20, 2009
Issued: April 2, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
Patent number: 8388674
Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
Type: Grant
Filed: February 25, 2009
Issued: March 5, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham
Application number: 20130012938
Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
Type: Application
Filed: December 3, 2010
Issued: January 10, 2013
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Samuel J. Asirvatham, Mark B. Knudson
Application number: 20120330351
Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
Type: Application
Filed: September 30, 2010
Issued: December 27, 2012
Assignees: Aegis Medical Innovations Inc., Mayo Foundation for Medical Reearch
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
Application number: 20120327204
Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
Type: Application
Filed: September 30, 2010
Issued: December 27, 2012
Assignees: Aegis Medical Innovations Inc., Mayo Foundation for Medical Education and Research
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
Patent number: 8315716
Abstract: The invention describes a steerable sheath for percutaneous epicardial access. The invention also describes a novel lead to facilitate left ventricular pacing and efficient defibrillation.
Type: Grant
Filed: October 9, 2009
Issued: November 20, 2012
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Paul A Friedman, Charles J Bruce, Samuel J Asirvatham
Application number: 20120245665
Abstract: An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.
Type: Application
Filed: September 2, 2010
Issued: September 27, 2012
Assignee: MAYO FOUNDATIONFOR MEDICAL EDUCATION AND RESEARCH
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham
Application number: 20120220890
Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
Type: Application
Filed: May 10, 2012
Issued: August 30, 2012
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
Patent number: 8204600
Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
Type: Grant
Filed: November 21, 2006
Issued: June 19, 2012
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
Application number: 20120150171
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/C1fA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Application
Filed: February 13, 2012
Issued: June 14, 2012
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
Application number: 20120143099
Abstract: Systems and methods for impairing smooth muscle tissue function using energy and/or pressure are described herein. The systems and/or methods may be used in some embodiments to target smooth muscle tissue in the bronchial passages.
Type: Application
Filed: June 1, 2010
Issued: June 7, 2012
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Craig E. Daniels, Samuel J. Asirvatham, Dorothy J. Ladewig
Patent number: 8162936
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Grant
Filed: February 20, 2009
Issued: April 24, 2012
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
Application number: 20120059459
Abstract: This document relates to materials and methods for circulatory bypass of a ventricle in the heart of a mammal. For example, materials and methods for bypassing a permanently or temporarily impaired left ventricle in the heart of a mammal (e.g., a human) are provided.
Type: Application
Filed: May 11, 2010
Issued: March 8, 2012
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Samuel J. Asirvatham, Soon J. Park, Paul A. Friedman, Charles J. Bruce, Sudhir S. Kushwaha
Application number: 20120022558
Abstract: Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
Type: Application
Filed: October 20, 2009
Issued: January 26, 2012
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
Application number: 20110224655
Abstract: Intracardiac devices that can provide a plurality of functions (e.g., pacing, defibrillation, cardiac assist, or valve replacement) via a single support member and control means.
Type: Application
Filed: September 11, 2009
Issued: September 15, 2011
Inventors: Samuel J. Asirvatham, Charles J. Bruce, Paul A. Friedman, Giovanni Speziali
Application number: 20110190756
Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
Type: Application
Filed: January 9, 2009
Issued: August 4, 2011
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham