Patents by Inventor Samuel J. Asirvatham

Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Publication number: 20160015294
Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
Type: Application
Filed: September 28, 2015
Publication date: January 21, 2016
Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM, TREVOR A. MCCAW, ELLIOT Y.K. HONG
Publication number: 20160015410
Abstract: This document relates to devices and methods for the treatment of heart conditions. For example, this document relates to devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.
Type: Application
Filed: March 11, 2014
Publication date: January 21, 2016
Inventors: Samuel J. Asirvatham, Barry A. Borlaug, Vojtech Melenovsky
Patent number: 9198683
Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
Type: Grant
Filed: September 30, 2010
Date of Patent: December 1, 2015
Assignees: AEGIS MEDICAL INNOVATIONS, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
Publication number: 20150297398
Abstract: This document provides methods and materials involved in disrupting electrical activity in the stomach. For example, methods and materials involved in delivering one or more electrical shocks to the stomach (e.g., the muscularis propria) in a manner that disrupts the normal electrical activity of the stomach (e.g., defibrillating the stomach) are provided.
Type: Application
Filed: October 24, 2013
Publication date: October 22, 2015
Inventors: Gianrico Farrugia, Navtej S. Buttar, Charles J. Bruce, Samuel J. Asirvatham, Elizabeth Rajan, Louis-Michel Wong Kee Song, Paul A. Friedman, Juliane Bingener-Casey, Michael J. Levy
Patent number: 9144431
Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
Type: Grant
Filed: September 30, 2010
Date of Patent: September 29, 2015
Assignees: AEGIS MEDICAL INNOVATIONS INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
Patent number: 9072890
Abstract: An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.
Type: Grant
Filed: September 2, 2010
Date of Patent: July 7, 2015
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham
Publication number: 20150094787
Abstract: This document provides methods and materials for treating syncope (e.g., neurocardiogenic syncope). For example, methods and materials involved in using electrical techniques to stimulate nerves (e.g., renal efferent and/or afferent nerves) in a manner that results in systemic blood vessel constriction and/or increased blood pressure are provided.
Type: Application
Filed: May 8, 2013
Publication date: April 2, 2015
Applicant: Mayo Foundation for Medical Education and Research
Inventors: Malini Madhavan, Samuel J. Asirvatham
Patent number: 8961543
Abstract: Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
Type: Grant
Filed: October 20, 2009
Date of Patent: February 24, 2015
Assignees: Mayo Foundation for Medical Education and Research, Aegis Medical Innovations Inc.
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
Publication number: 20150018853
Abstract: Devices and methods for ligating anatomical structures are provided herein. In particular, the devices and methods provided herein can be used to ligate, the left atrial appendage. The ligating devices (10, 110, 210, 310, 410) comprise a ligating element (30, 130, 230, 330, 430) and a control element (40, 140, 240, 340, 430) which controls the opening of the ligating element in a loop or lariat shape. Some embodiments comprise also a positioning element (50, 150) which help position the ligating element. In some embodiments a conduit (250) is provided for deploying the ligating element by inflating control.
Type: Application
Filed: October 2, 2014
Publication date: January 15, 2015
Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM
Publication number: 20140324040
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Application
Filed: July 14, 2014
Publication date: October 30, 2014
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
Publication number: 20140296680
Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
Type: Application
Filed: June 13, 2014
Publication date: October 2, 2014
Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
Patent number: 8812099
Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
Type: Grant
Filed: November 16, 2012
Date of Patent: August 19, 2014
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes
Patent number: 8790338
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Grant
Filed: February 13, 2012
Date of Patent: July 29, 2014
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
Publication number: 20140058282
Abstract: A gastro-electrical activity mapping system and method may comprise a catheter insertable through a natural orifice into the gastro-intestinal (GI) tract and comprising an array of electrodes for contacting an interior surface of a section of the GI tract to detect electrical potentials at multiple electrodes, and comprises a signal analysis and mapping system arranged to receive and process electrical signals from multiple electrodes of the array and spatially map GI smooth muscle electrical activity as an activation time map, a velocity map, or an amplitude map, which may be in the form of contour plots and may be mapped on an anatomical computer model of at least the section of the GI tract and may be animated.
Type: Application
Filed: October 18, 2011
Publication date: February 27, 2014
Applicants: Mayo Foundation for Medical Education and Research, Auckland Uniservices Limited
Inventors: Gregory B. O'Grady, Leo K. Cheng, Andrew J. Pullan, Peng Du, Nira Paskaranandavadivel, Timothy R. Angeli, Gianrico Farrugia, Samuel J. Asirvatham
Patent number: 8538501
Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
Type: Grant
Filed: January 9, 2009
Date of Patent: September 17, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
Patent number: 8409192
Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
Type: Grant
Filed: February 20, 2009
Date of Patent: April 2, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
Patent number: 8388674
Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
Type: Grant
Filed: February 25, 2009
Date of Patent: March 5, 2013
Assignee: Mayo Foundation for Medical Education and Research
Inventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham
Publication number: 20130012938
Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
Type: Application
Filed: December 3, 2010
Publication date: January 10, 2013
Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors: Samuel J. Asirvatham, Mark B. Knudson
Publication number: 20120327204
Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
Type: Application
Filed: September 30, 2010
Publication date: December 27, 2012
Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical Education and Research
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
Publication number: 20120330351
Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
Type: Application
Filed: September 30, 2010
Publication date: December 27, 2012
Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical Reearch
Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
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