Patents by Inventor Samuel J. Asirvatham

Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160151105
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20160074043
    Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 17, 2016
    Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM, TREVOR A. MCCAW, ELLIOT Y.K. HONG
  • Patent number: 9271786
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: March 1, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20160051322
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: April 15, 2014
    Publication date: February 25, 2016
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20160015294
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Application
    Filed: September 28, 2015
    Publication date: January 21, 2016
    Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM, TREVOR A. MCCAW, ELLIOT Y.K. HONG
  • Publication number: 20160015410
    Abstract: This document relates to devices and methods for the treatment of heart conditions. For example, this document relates to devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 21, 2016
    Inventors: Samuel J. Asirvatham, Barry A. Borlaug, Vojtech Melenovsky
  • Patent number: 9198683
    Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: December 1, 2015
    Assignees: AEGIS MEDICAL INNOVATIONS, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
  • Publication number: 20150297398
    Abstract: This document provides methods and materials involved in disrupting electrical activity in the stomach. For example, methods and materials involved in delivering one or more electrical shocks to the stomach (e.g., the muscularis propria) in a manner that disrupts the normal electrical activity of the stomach (e.g., defibrillating the stomach) are provided.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 22, 2015
    Inventors: Gianrico Farrugia, Navtej S. Buttar, Charles J. Bruce, Samuel J. Asirvatham, Elizabeth Rajan, Louis-Michel Wong Kee Song, Paul A. Friedman, Juliane Bingener-Casey, Michael J. Levy
  • Patent number: 9144431
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: September 29, 2015
    Assignees: AEGIS MEDICAL INNOVATIONS INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
  • Patent number: 9072890
    Abstract: An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: July 7, 2015
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham
  • Publication number: 20150094787
    Abstract: This document provides methods and materials for treating syncope (e.g., neurocardiogenic syncope). For example, methods and materials involved in using electrical techniques to stimulate nerves (e.g., renal efferent and/or afferent nerves) in a manner that results in systemic blood vessel constriction and/or increased blood pressure are provided.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 2, 2015
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Malini Madhavan, Samuel J. Asirvatham
  • Patent number: 8961543
    Abstract: Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: February 24, 2015
    Assignees: Mayo Foundation for Medical Education and Research, Aegis Medical Innovations Inc.
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
  • Publication number: 20150018853
    Abstract: Devices and methods for ligating anatomical structures are provided herein. In particular, the devices and methods provided herein can be used to ligate, the left atrial appendage. The ligating devices (10, 110, 210, 310, 410) comprise a ligating element (30, 130, 230, 330, 430) and a control element (40, 140, 240, 340, 430) which controls the opening of the ligating element in a loop or lariat shape. Some embodiments comprise also a positioning element (50, 150) which help position the ligating element. In some embodiments a conduit (250) is provided for deploying the ligating element by inflating control.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 15, 2015
    Inventors: PAUL A. FRIEDMAN, CHARLES J. BRUCE, SAMUEL J. ASIRVATHAM
  • Publication number: 20140324040
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20140296680
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
  • Patent number: 8812099
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: August 19, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes
  • Patent number: 8790338
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: July 29, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20140058282
    Abstract: A gastro-electrical activity mapping system and method may comprise a catheter insertable through a natural orifice into the gastro-intestinal (GI) tract and comprising an array of electrodes for contacting an interior surface of a section of the GI tract to detect electrical potentials at multiple electrodes, and comprises a signal analysis and mapping system arranged to receive and process electrical signals from multiple electrodes of the array and spatially map GI smooth muscle electrical activity as an activation time map, a velocity map, or an amplitude map, which may be in the form of contour plots and may be mapped on an anatomical computer model of at least the section of the GI tract and may be animated.
    Type: Application
    Filed: October 18, 2011
    Publication date: February 27, 2014
    Applicants: Mayo Foundation for Medical Education and Research, Auckland Uniservices Limited
    Inventors: Gregory B. O'Grady, Leo K. Cheng, Andrew J. Pullan, Peng Du, Nira Paskaranandavadivel, Timothy R. Angeli, Gianrico Farrugia, Samuel J. Asirvatham
  • Patent number: 8538501
    Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 17, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
  • Patent number: 8409192
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 2, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam