Patents by Inventor Samuel J. Wohlstadter
Samuel J. Wohlstadter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210301037Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: March 23, 2021Publication date: September 30, 2021Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10988552Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: July 14, 2020Date of Patent: April 27, 2021Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Patent number: 10964415Abstract: A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.Type: GrantFiled: July 24, 2017Date of Patent: March 30, 2021Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel L. Moore, Samuel J. Wohlstadter, Charles Quentin Davis, Glen Otero, Aaron S. Haleva
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Publication number: 20200339707Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: July 14, 2020Publication date: October 29, 2020Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10752704Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: October 29, 2019Date of Patent: August 25, 2020Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20200062866Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: October 29, 2019Publication date: February 27, 2020Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10519253Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: February 5, 2019Date of Patent: December 31, 2019Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20190169315Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: February 5, 2019Publication date: June 6, 2019Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10259888Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: May 1, 2017Date of Patent: April 16, 2019Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20180251573Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: May 1, 2017Publication date: September 6, 2018Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Publication number: 20170323078Abstract: A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.Type: ApplicationFiled: July 24, 2017Publication date: November 9, 2017Inventors: Francis MICHON, Samuel L. MOORE, Samuel J. WOHLSTADTER, Charles Quentin DAVIS, Glen OTERO, Aaron S. HALEVA
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Publication number: 20140156304Abstract: A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.Type: ApplicationFiled: July 25, 2013Publication date: June 5, 2014Applicant: WELLSTAT VACCINES, LLCInventors: Francis MICHON, Samuel L. MOORE, Samuel J. WOHLSTADTER, Charles Quentin DAVIS, Glen OTERO, Aaron S. HALEVA
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Patent number: 8498879Abstract: A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.Type: GrantFiled: November 10, 2008Date of Patent: July 30, 2013Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel L. Moore, Samuel J. Wohlstadter, Charles Quentin Davis, Glen Otero, Aaron Haleva
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Patent number: 8234129Abstract: A system and method for assessing immunological status of individuals and populations is presented. The method includes establishing a database containing a plurality of records, each record containing information representative of the immune status of an individual, including (1) bioassay results, and (2) individual specific information such as, medical history, clinical observations and historical, demographic, lifestyle, and familial/genetic information. By processing the information trends and/or patterns are obtained correlating various variables in the records across an individual, population or sub-population. The identified trends and/or patterns can, for example, be used in health care related decision making. In exemplary embodiments such processing can include generating a set of correlations and for each correlation generating a set of explanatory or relevant hypotheses. Then, for example, each hypothesis can be automatically refuted or supported, to the extent possible.Type: GrantFiled: April 27, 2007Date of Patent: July 31, 2012Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel L. Moore, Peter C. Fusco, Samuel J. Wohlstadter, Charles Quentin Davis, Aaron Haleva
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Publication number: 20090299767Abstract: A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.Type: ApplicationFiled: November 10, 2008Publication date: December 3, 2009Applicant: 32 Mott Street Acquisition I LLC, d/b/a/Wellstat VaccinesInventors: Francis Michon, Samuel L. Moore, Samuel J. Wohlstadter, Charles Quentin Davis, Glen Otero, Aaron Haleva