Patents by Inventor Samuel Klein
Samuel Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952421Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.Type: GrantFiled: October 8, 2015Date of Patent: April 9, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Minh Diem Vu, Klaus Strein, Oliver Ast, Tanja Fauti, Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Samuel Moser, Ramona Murr, Pablo Umana, Sabine Jung-Imhof, Stefan Klostermann, Michael Molhoj, Joerg Regula, Wolfgang Schaefer
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Publication number: 20150216696Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: ApplicationFiled: April 10, 2015Publication date: August 6, 2015Inventors: SAMUEL KLEIN, STEPHEN B. SOLOMON, MOSHE SHIKE, DEAN KAMEN, MICHAEL AMBROGI, DAVID E. ALTOBELLI, ERIC YEATON
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Patent number: 9055995Abstract: The present invention is directed to an apparatus and method for treating obesity. An artificial obstruction is introduced into the patient's gastrointestinal tract, and a tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: GrantFiled: October 21, 2009Date of Patent: June 16, 2015Assignee: Aspire Bariatrics, Inc.Inventors: Kenneth S. Solovay, Samuel Klein, Stephen B. Solomon, Moshe Shike
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Patent number: 9039677Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: GrantFiled: September 11, 2012Date of Patent: May 26, 2015Assignee: Aspire Bariatrics, Inc.Inventors: Samuel Klein, Stephen B. Solomon, Moshe Shike, Dean Kaman, Michael Ambrogi, David E. Altobelli, Eric Yeaton
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Publication number: 20140323955Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: ApplicationFiled: July 8, 2014Publication date: October 30, 2014Inventors: DEAN KAMEN, KEVIN L. GRANT, ERIC M. SOEDERBERG, DAVID E. ALTOBELLI, DAVID M. FLYNN, KENNETH S. SOLOVAY, SAMUEL KLEIN
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Patent number: 8808221Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: GrantFiled: March 2, 2013Date of Patent: August 19, 2014Assignee: Aspire Bariatrics, Inc.Inventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David M. Flynn, Kenneth S. Solovay, Samuel Klein
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Patent number: 8632513Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: GrantFiled: April 1, 2011Date of Patent: January 21, 2014Assignee: Aspire Bariatrics, Inc.Inventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David Flynn, Kenneth S. Solovay, Samuel Klein
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Publication number: 20130289474Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: ApplicationFiled: March 2, 2013Publication date: October 31, 2013Inventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David M. Flynn, Kenneth S. Solovay, Samuel Klein
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Patent number: 8414561Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: GrantFiled: February 15, 2007Date of Patent: April 9, 2013Assignee: Aspire Bariatrics, LLCInventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David M. Flynn, Kenneth S. Solovay, Samuel Klein
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Publication number: 20130006166Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: ASPIRE BARIATRICS LLCInventors: Samuel Klein, Stephen B. Solomon, Moshe Shike, Dean Kamen, Michael Ambrogi, David E. Altobelli, Eric Yeaton
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Patent number: 8282623Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: GrantFiled: October 22, 2009Date of Patent: October 9, 2012Assignee: Aspire Bariatrics LLCInventors: Samuel Klein, Stephen B. Solomon, Moshe Shike
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Patent number: 8062285Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: GrantFiled: February 15, 2007Date of Patent: November 22, 2011Assignee: Aspire Bariatrics, LLCInventors: Tim Langloss, Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David M. Flynn, Kenneth S. Solovay, Samuel Klein
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Patent number: 8002758Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: GrantFiled: August 3, 2007Date of Patent: August 23, 2011Assignee: Aspire Bariatrics, LLCInventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David Flynn, Kenneth S. Solovay, Samuel Klein
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Publication number: 20110190719Abstract: When a patient is fitted with an external gastrostomy connection to the stomach, ingested food can be removed through the gastrostomy connection using a pump-based or siphon-based system to achieve weight loss. The process of removing ingested food can be improved by alternating the infusion of liquid into the stomach with the removal of material from the stomach. Optionally, stomach acid may be captured and returned to the stomach. Optionally, nutritional supplements or medicines may be added to the infused liquid. Optionally, a flush mount connectorized system with a built in valve may be used to simplify the interface with the gastrostomy hardware that remains installed in the patient. Optionally, the system may be configured to disable itself from further use after a triggering event (e.g., the passage of time or a predetermined number of uses) has occurred.Type: ApplicationFiled: April 1, 2011Publication date: August 4, 2011Applicant: ASPIRE BARIATRICS, LLCInventors: Dean Kamen, Kevin L. Grant, Eric M. Soederberg, David E. Altobelli, David Flynn, Kenneth S. Solovay, Samuel Klein
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Publication number: 20110178480Abstract: To treat obesity, a tube is positioned so that it passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After ingestion, food is extracted by pumping it out of the upper digestive system through the tube. The embodiments described herein take advantage of some properties of ePTFE to provide a number of significant advantages.Type: ApplicationFiled: March 28, 2011Publication date: July 21, 2011Applicant: ASPIRE BARIATRICS, LLCInventors: Kenneth Solovay, Samuel Klein, Stephen B. Solomon, Moshe Shike
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Publication number: 20110082442Abstract: The length of a reinforced tube that is made of a fluid-tight tube with an external helical support structure and an elastomeric material disposed at least in the trough between successive turns of the helical support can be adjusted by peeling a strip of the elastomeric material away from the trough. This renders a portion of the helical support structure usable as an external thread, after which an internally threaded structure can be screwed down onto the helical support structure.Type: ApplicationFiled: September 7, 2010Publication date: April 7, 2011Inventors: Kenneth S. Solovay, Samuel Klein, Stephen B. Solomon, Moshe Shike
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Patent number: 7815629Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: GrantFiled: July 27, 2005Date of Patent: October 19, 2010Assignee: DEKA Products Limited PartnershipInventors: Samuel Klein, Stephen B Solomon, Moshe Shike, Dean Kamen, Michael Ambrogi, David E Altobelli, Eric Yeaton
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Publication number: 20100241090Abstract: The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: ApplicationFiled: June 2, 2010Publication date: September 23, 2010Inventors: Samuel Klein, Stephen B. Solomon, Moshe Shike, Dean Kamen, Michael Ambrogi, David E. Altobelli, Eric Yeaton
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Patent number: 7740624Abstract: To treat obesity, a tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. This approach is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: GrantFiled: July 27, 2005Date of Patent: June 22, 2010Assignee: Aspiration Medical Technology, LLCInventors: Samuel Klein, Stephen B. Solomon, Moshe Shike
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Publication number: 20100106130Abstract: The present invention is directed to an apparatus and method for treating obesity. An artificial obstruction is introduced into the patient's gastrointestinal tract, and a tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.Type: ApplicationFiled: October 21, 2009Publication date: April 29, 2010Inventors: Kenneth S. Solovay, Samuel Klein, Stephen B. Solomon, Moshe Shike