Abstract: Disclosed herein are methods for identifying patients with pancreatic cancer and subjects at risk for developing pancreatic cancer, methods for monitoring a patient with an identified pancreatic lesion, methods for evaluating the effectiveness of a treatment used for a patient with pancreatic cancer, and methods for selecting a therapy for treating pancreatic cancer in a particular patient. The invention makes use of hydroxymethylation biomarkers, which in combination with one or more clinical parameters and optionally one or more additional types of biomarkers and/or patient-specific risk factors, exhibit a hydroxymethylation level that correlates with pancreatic cancer. Kits and other methods of use are also provided.

Abstract: A method is provided for probabilistically assigning a tissue of origin to a nucleic acid in a sample, e.g., DNA in a cell-free fluid sample obtained from a human subject. A hydroxymethylation profile is generated for the sample DNA and then compared across a reference data set of hydroxymethylation profile vectors, where each hydroxymethylation profile vector identifies the hydroxymethylation profile at a specific reference locus, the tissue-specific gene associated with the reference locus, and the tissue with which the gene and reference locus are associated. A tissue of origin can be probabilistically assigned to the sample nucleic acid using the results of the comparison. Other methods of use are also provided.

Abstract: The invention disclosed herein generally relates to methods of assessing and monitoring tumor load through analysis of tumor DNA in cancer patients. Quantitative measures derived from cell-free DNA and germline DNA are used to assess and monitor tumor load. By assessing and monitoring tumor load, cancer may be detected in a subject. The tumor load of a subject may be assessed at a number of different time points to monitor a progression, regression, or recurrence of cancer in a subject.

Abstract: The invention disclosed herein generally relates to methods of assessing and monitoring tumor load through analysis of tumor DNA in cancer patients. Quantitative measures derived from cell-free DNA and germline DNA are used to assess and monitor tumor load. By assessing and monitoring tumor load, cancer may be detected in a subject. The tumor load of a subject may be assessed at a number of different time points to monitor a progression, regression, or recurrence of cancer in a subject.

Abstract: The invention provides a method for the analysis of a biological sample to determine multiple types of information therefrom in a streamlined, combined workflow, where all information is obtained in a sequencing-based analysis. The information includes the presence and concentration of specific plasma proteins in a blood sample; the number, location, and types of histone modifications associated with cell-free DNA obtained from the same sample; the sequence of cfRNA and cfDNA in the cell-free DNA sample; and epigenetic information pertaining to the cell-free DNA, such as hydroxymethylation and methylation profiles, i.e., the distribution of 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) residues, respectively. The invention additionally pertains to a classical sequencing-based method for analyzing a biological sample to determine one or more non-classical sequence features of the sample.

Abstract: The present invention relates to a method, system, and apparatus of flight system for individual users using electric ducted fans. The flight system comprises a modular unit, which comprises a plurality of electric ducted fans, means for connecting electric ducted fans, and a pair of armpit supports. The flight system further comprises means for securing a modular unit around respective left and right shoulders of a user. In one embodiment, the flight system can be controlled to generate a horizontal acceleration of 20 MPH/second and a vertical acceleration of 10 MPH/second.

Abstract: A roof-mounted automobile surveillance apparatus for creating a surveillance network on streets to improve public safety includes a base to attach to a roof of a vehicle. A dome cover is coupled to the base outer edge and extends above the base top side. The dome cover is transparent and weatherproof. A camera housing is coupled to the base. The camera housing is coupled to the base top side within the dome cover. A camera is coupled within the camera housing. The camera has a plurality of lenses extending through the camera housing. A CPU, a battery, a memory card slot, a GPS transceiver, and a cellular transceiver are coupled to the base within the base inside.

Abstract: Disclosed herein are methods for identifying patients likely to have pancreatic ductal adenocarcinoma (PDAC) and patients likely to be at risk for developing PDAC. Related methods are also provided that pertain to patient monitoring, treatment evaluation, and an improved multi-cancer test., as are kits that are suitable for carrying out the aforementioned methods. The invention makes use of hydroxymethylation biomarkers, which in combination with one or more clinical parameters and optionally one or more additional types of biomarkers and/or patient-specific risk factors, exhibit a hydroxymethylation level that correlates with the presence of or risk of developing PDAC.

Abstract: This invention describes a thermoelectric energy generation device based on the ExB drift in a semiconductor. The material is in depletion mode to avoid cancellation of the electric field by space charges. Under ideal, infinite mobility, zero-collision conditions, electrons and holes drift in the same direction, perpendicularly to the electric and magnetic fields, resulting in a zero-output current. However, when mobility is finite, their differing properties such as mobility, effective mass, and charge, manifest themselves as different drift velocity and drift direction resulting in a net output current and power. This invention leverages carriers' properties to accentuate these differences and maximize the output power.

Abstract: This invention describes a thermoelectric energy generation device based on the ExB drift in a semiconductor. The material is in depletion mode to avoid cancellation of the electric field by space charges. Under ideal, infinite mobility, zero-collision conditions, electrons and holes drift in the same direction, perpendicularly to the electric and magnetic fields, resulting in a zero-output current. However, when mobility is finite, their differing properties such as mobility, effective mass, and charge, manifest themselves as different drift velocity and drift direction resulting in a net output current and power. This invention leverages carriers' properties to accentuate these differences and maximize the output power.

Abstract: Disclosed herein are methods for identifying patients with pancreatic cancer and subjects at risk for developing pancreatic cancer, methods for monitoring a patient with an identified pancreatic lesion, methods for evaluating the effectiveness of a treatment used for a patient with pancreatic cancer, and methods for selecting a therapy for treating pancreatic cancer in a particular patient. The invention makes use of hydroxymethylation biomarkers, which in combination with one or more clinical parameters and optionally one or more additional types of biomarkers and/or patient-specific risk factors, exhibit a hydroxymethylation level that correlates with pancreatic cancer. Kits and other methods of use are also provided.

Abstract: The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.

Abstract: A method is provided for probabilistically assigning a tissue of origin to a nucleic acid in a sample, e.g., DNA in a cell-free fluid sample obtained from a human subject. A hydroxymethylation profile is generated for the sample DNA and then compared across a reference data set of hydroxymethylation profile vectors, where each hydroxymethylation profile vector identifies the hydroxymethylation profile at a specific reference locus, the tissue-specific gene associated with the reference locus, and the tissue with which the gene and reference locus are associated. A tissue of origin can be probabilistically assigned to the sample nucleic acid using the results of the comparison. Other methods of use are also provided.

Abstract: The invention disclosed herein generally relates to methods of assessing and monitoring tumor load through analysis of tumor DNA in cancer patients. Quantitative measures derived from cell-free DNA and germline DNA are used to assess and monitor tumor load. By assessing and monitoring tumor load, cancer may be detected in a subject. The tumor load of a subject may be assessed at a number of different time points to monitor a progression, regression, or recurrence of cancer in a subject.

Abstract: The present invention relates to a method, system, and apparatus of flight system for individual users using electric ducted fans. The flight system comprises a modular unit, which comprises a plurality of electric ducted fans, means for connecting electric ducted fans, and a pair of armpit supports. The flight system further comprises means for securing a modular unit around respective left and right shoulders of a user. In one embodiment, the flight system can be controlled to generate a horizontal acceleration of 20 MPH/second and a vertical acceleration of 10 MPH/second.

Abstract: When a magnetic field is applied parallel to a layer of thermoelectric material, and an electric field is applied perpendicular to the layer, electrical carriers in the layer follow cyclotron orbits interrupted by one of the layer's surfaces. These interrupted orbits produce a drift current along the layer and perpendicular to both fields. Therefore, the inputs are a magnetic field and an electric field, and the output is a current. The phenomenon differs from the classical Hall Effect in which the inputs are a magnetic field and a current and the output is a voltage. The output current produces electrical energy which can be used immediately, stored for later consumption, converted to another form or transmitted to another location. Layers can be stacked, each layer of the stack mutually reinforcing the electrical field in the adjacent stack layers. Stacked layers can be connected in series or parallel.

Abstract: The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.