Abstract: One or more techniques for optimizing cancer classification based on covariate characteristics is disclosed. In a first approach, an analytics system may determine separate cutoff thresholds for positively detecting disease signal for different labels for a covariate characteristic. The system may subdivide training samples based on their labels for the covariate characteristic, to separately determine the cutoff thresholds. In other approaches, the system may train disparate classifiers for each population. The system separates the training samples based on their labels for the covariate characteristic, and separately trains classifiers to generate a signal vector representing an amount of disease signal detected in a sample. The classifiers may be trained on different feature sets as determined based on mutual information gain, genomic region coverage, and healthy activation fraction.

Abstract: Methods and systems for training a model include performing two-dimensional object detection on a training image to identify an object. The training image is cropped around the object. A category-level shape reconstruction is generated using a neural radiance field model. A normalized coordinate model is trained using the training image and ground truth information from the category-level shape reconstruction.

Abstract: Methods and systems for training a model include training a size estimation model to generate an estimated object size using a training dataset with differing levels of annotation. Two-dimensional object detection is performed on a training image to identify an object. The training image is cropped around the object. A category-level shape reconstruction is generated using a neural radiance field model. A normalized coordinate model is trained using the training image and ground truth information from the category-level shape reconstruction.

Abstract: A system can receive data relating to a tubular of a well system. The system can execute a first module to determine first outputs. The system can execute a second module to determine second outputs based on the first outputs. The system can execute a third module to determine third outputs based on the first outputs. The second outputs can include a crack-initiation fracture pressure, and the third outputs can include a crack-propagation fracture pressure. The system can identify a brittle-burst strength of the tubular from among the second outputs, the third outputs, and a standard burst strength of the tubular. The system can provide the brittle-burst strength of the tubular to facilitate an adjustment to the tubular to optimize a wellbore operation associated with the well system.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure relates to a substrate apparatus (and methods of manufacturing the same) with one or more substrates having a substrate spacing for growing a cell mass. In particular embodiments, the disclosed substrate apparatus includes a substrate wound into a coiled configuration with an intra-coil spacing between coil layers. To provide the intra-coil spacing, certain implementations use a separator. For example, a separator is applied to a substrate surface, and the separator-substrate combination is wound together (e.g., around a spool). In turn, a locking element is attached to the substrate to maintain the coiled configuration. The separator is then removed via heat treatment, chemical treatment, or physical displacement—thereby leaving the intra-coil spacing between the coil layers. Alternatively, no separator is used to provide a substrate spacing. For example, in lieu of a separator, the locking element is actively applied to the substrate during the winding process.

Abstract: A platform for processing a workpiece includes a transmission mechanism, a plurality of workstations and a plurality of movable vehicles. The transmission mechanism transports the workpiece to be processed to one of the plurality of workstations. Each movable vehicle includes a processing module and a docking interface adapted to connect with a docking station of each workstation. The movable vehicles are each adapted to move in and out of each workstation, and each processing module is adapted to process the workpiece transmitted to the workstation after the movable vehicle is moved in and positioned in the workstation.

Abstract: A system can generate, via a software model, downhole pressure estimations and downhole debris estimations using caving parameters. Additionally, the system can generate, via the software model, settled caving volume percent estimations using the caving parameters. The system can determine a pack off volume percent using the downhole pressure estimations, the downhole debris estimations, and the settled caving volume percent estimations. The system can output, via a user interface, the pack off indicator and a subset of the caving parameters for use in adjusting a wellbore operation. The user interface can provide a plot of the pack off volume percent horizontally offset with respect to a plot of the subset of the caving parameters and a depth of the wellbore.

Abstract: A surface cleaning device includes a nozzle and an odor dial assembly. The nozzle includes a nozzle housing and a dirty air passageway. The odor dial assembly include a fragrance member and a dial body configured to be removably coupled to the nozzle housing. The dial body at least partially defines a fragrance cavity configured to at least partially receive the fragrance member and a fragrance passageway extending therethrough. The odor dial assembly is configured to transition between a plurality of user-selectable positions to adjust an amount of fragrance particles released by the fragrance member into the dirty air passageway.

Abstract: The invention relates to generating cryptographic tokens based on characteristic determination. The system may generate and transmit a request for encrypted records from a blockchain node, receive the encrypted records from the blockchain node, decrypt the encrypted records into payload identifiers, retrieve sets of item identifiers based on the payload identifiers, determine characteristics associated with the sets of items, and generate a new cryptographic token that indicates the characteristics.

Abstract: The invention relates to generating cryptographic tokens based on received records. The system may receive a blockchain operation request comprising a plurality of records, encrypt a plurality of records into an encrypted payload, generate a cryptographic token based on the encrypted payload, and cause the cryptographic token to be committed to a blockchain.

Abstract: A method for controlling computerized operations related to a wellbore comprises drilling the wellbore in a subsurface formation with a drill string including a drill bit. The method comprises acquiring a plurality of drilling parameters while drilling the wellbore. The method comprises determining, based on the plurality of drilling parameters, solids properties for solids forming a cutting plug up hole of the drill bit. The method comprises determining a length of the cutting plug based on the solids properties. The method comprises determining a cutting plug friction force based on the cutting plug length and a pressure differential across the cutting plug. The method comprises performing a drilling operation based on the cutting plug friction force.

Abstract: A method for controlling computerized operations related to a wellbore comprises drilling the wellbore in a subsurface formation with a drill string including a drill bit. The method comprises acquiring a plurality of drilling parameters while drilling the wellbore. The method comprises determining, based on the plurality of drilling parameters, solids properties for solids forming a cutting plug up hole of the drill bit. The method comprises determining a length of the cutting plug based on the solids properties. The method comprises determining a cutting plug friction force based on the cutting plug length and a pressure differential across the cutting plug. The method comprises performing a drilling operation based on the cutting plug friction force.

Abstract: The object collecting heads for object collecting systems includes several embodiments of object collecting heads including light and heavy-duty object collecting heads. The object collecting heads are used to grasp and convey differently sized and randomly shaped objects from a surface to an object holding bin of the object collecting system and are attached to the object holding bin using an adjustable support assembly. Both object collecting heads have three blocks including an upper block, a lower left block, and a lower right block. The lower blocks are connected to each other and the adjustable support assembly by an angled lower block bracket. The upper block is attached to the lower blocks by spring-loaded hinges, such that the upper block is urged toward the lower blocks to grasp an object therebetween. The light-duty object collecting head is a chain-based head, while the heavy-duty object collecting head is a roller-based head.

Abstract: The elevating lift with a stabilized movable base includes a base with extendable legs that provide minimum to maximum adjustable stability during use and transport. A lift system is mounted on the base, and a platform assembly is mounted on top of the lift system for selective raising or lowering. Each extendable leg supports a caster, rendering the base movable, and selective extension and retraction of the legs adjusts the stability of the lift. The plurality of legs can be further driven to simultaneously rotate about the vertical axis to steer the lift. The stabilized movable base is further alternatively used in combination with a stool, providing minimum to maximum stability during use and transport of seating, and multiple to elevating lifts may be used to support linked platform assemblies in various configurations.

Abstract: An embodiment of a computing system is configured to process data using a multithreaded SIMD architecture that includes heterogeneous processing engines to execute a program. The program is constructed of various program instructions. A first type of the program instructions can only be executed by a first type of processing engine and a third type of program instructions can only be executed by a second type of processing engine. A second type of program instructions can be executed by the first and the second type of processing engines. An assignment unit may be configured to dynamically determine which of the two processing engines executes any program instructions of the second type in order to balance the workload between the heterogeneous processing engines.

Abstract: A method and apparatus for multiplexing multiple Ethernet-based data streams in an optical network reduce the number of optical transceivers required by the optical network. Multiple data streams are multiplexed into a combined data stream, transmitted from a node in the optical network as the combined data stream, and demultiplexed at the receiving node. Data streams are multiplexed and demultiplexed at the bit level, and packets from each data stream are routed based on a VLAN tag that is contained in the header of each packet. By transmitting the information contained in multiple data streams as a single multiplexed data stream, the number of optical transceivers required for the optical network may be reduced by more than half. An optical supervisory channel may also be bundled with one of the data streams to eliminate the need for a dedicated transceiver for the optical supervisory channel.

Abstract: An apparatus and method for simulating a multi-ported memory using lower port count memories as banks. A collector units gather source operands from the banks as needed to process program instructions. The collector units also gather constants that are used as operands. When all of the source operands needed to process a program instruction have been gathered, a collector unit outputs the source operands to an execution unit while avoiding writeback conflicts to registers specified by the program instruction that may be accessed by other execution units.

Abstract: The present invention provides a switch assembly for use with a single-port OPM to realize a multi-port OPM having improved reliability. In one embodiment, an N×1 optical switch assembly, wherein N is an integer greater than one, is provided. The optical switch assembly includes N optical input ports, N micro-electro-mechanical system (MEMS) variable optical attenuators (VOAs), where each MEMS VOA is optically coupled to a respective optical input port and is operable between an on position and an off position, and an N×1 optical combiner optically coupled to the N MEMS VOAs. Each MEMS VOA is configured to transmit an optical signal from a respective one of the optical input ports to the N×1 optical combiner in the on position and to not transmit the optical signal in the off position.

Abstract: A shared memory is usable by concurrent threads in a multithreaded processor, with any addressable storage location in the shared memory being readable and writeable by any of the threads. Processing engines that execute the threads are coupled to the shared memory via an interconnect that transfers data in only one direction (e.g., from the shared memory to the processing engines); the same interconnect supports both read and write operations. The interconnect advantageously supports multiple parallel read or write operations.