Patents by Inventor Samuel Nochumson
Samuel Nochumson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8802448Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.Type: GrantFiled: July 23, 2012Date of Patent: August 12, 2014Assignee: Pall CorporationInventors: Hassan Ait-Haddou, Frank Onyemauwa, Jonathan Haigh, Samuel Nochumson
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Publication number: 20130030154Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.Type: ApplicationFiled: July 23, 2012Publication date: January 31, 2013Applicant: PALL CORPORATIONInventors: Hassan AIT-HADDOU, Frank ONYEMAUWA, Jonathan HAIGH, Samuel NOCHUMSON
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Patent number: 8236495Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.Type: GrantFiled: January 9, 2006Date of Patent: August 7, 2012Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuowei Wu, Rexford Hayes
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Patent number: 7732216Abstract: Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.Type: GrantFiled: November 17, 2006Date of Patent: June 8, 2010Assignee: Pall CorporationInventors: Samuel Nochumson, Peter Levison
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Publication number: 20080299672Abstract: Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.Type: ApplicationFiled: November 17, 2006Publication date: December 4, 2008Applicant: PALL CORPORATIONInventors: Samuel Nochumson, Peter Levison
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Publication number: 20060106208Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.Type: ApplicationFiled: January 9, 2006Publication date: May 18, 2006Applicant: Valentis, IncInventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
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Patent number: 7026468Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective, contgrollable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and nuetralization.Type: GrantFiled: January 29, 2001Date of Patent: April 11, 2006Assignee: Valentis, Inc.Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
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Publication number: 20030211970Abstract: Disclosed is a method for processing a plasmid-containing fluid comprising contacting the plasmid-containing fluid with two charged membranes and obtaining a plasmid-enriched fluid such as a purified plasmid. In an embodiment, the first charged membrane is positively charged, and the second charged membranes is positively or negatively charged membrane. In a preferred embodiment, both first and second charged membranes are positively charged. In another embodiment, the plasmid-containing fluid is contacted with two positively charged membranes and a third charged membrane. The present invention further provides a system and a kit for processing plasmid-containing fluids.Type: ApplicationFiled: November 19, 2002Publication date: November 13, 2003Inventors: Samuel Nochumson, Yujing Yang, Joe L. Kinsey Jr
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Publication number: 20010034435Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.Type: ApplicationFiled: January 29, 2001Publication date: October 25, 2001Applicant: Valentis, Inc.Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
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Patent number: 5552325Abstract: Disclosed is a centrifuge tube containing a porous selection means for selectively separating and recovering biological substances from gels, broths, or solutions containing the same, and thus concentrating them, the tube comprising separate upper and lower containers and means for joining the two containers to form a unitary device, the bottom of the upper container comprising a porous selection means, preferably a membrane containing a particulate substance which will selectively bind the biological substances while allowing unbound substances to pass through from the upper to lower container while being centrifuged.Type: GrantFiled: July 17, 1992Date of Patent: September 3, 1996Assignee: FMC CorporationInventors: Samuel Nochumson, Bruce S. Goldberg
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Patent number: 5455344Abstract: A nucleic acid sequencing gel comprising 2 to 10% of a gelling polysaccharide, preferably agarose; a denaturing agent, a non-gelling additive, preferably glycerol, and electrophoretic buffers. This composition is capable of resolving nucleic acid fragments having at least 50 bases and which differ from each other by at least one base.Type: GrantFiled: September 3, 1993Date of Patent: October 3, 1995Assignee: FMC CorporationInventors: David L. Harper, Jonathan H. Morgan, Samuel Nochumson, Mikhail V. Ostrovsky, Donald W. Renn, William C. Snow
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Patent number: 5143646Abstract: Electrophoretic resolving gel compositions, discontinuous stacking gel systems containing these and other resolving gel compositions, and kits for preparing such gel systems, comprising one or more polysaccharide hydrogels of which agarose is typical wherein at least one of the gels in the resolving gel composition has been derivatized and at least one of the gels in the resolving gel composition has been depolymerized sufficiently to reduce its casting-effective viscosity.Type: GrantFiled: June 20, 1991Date of Patent: September 1, 1992Assignee: FMC CorporationInventors: Samuel Nochumson, Foner P. Curtis, Jonathan H. Morgan, Francis H. Kirkpatrick
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Patent number: 5053332Abstract: A method for forming agarose beads, which may incorporate biological material at least partially labile at above 40.degree. C., in which an aqueous agarose solution is formed into bead-size portions which are gelled by contacting the portions with a cooled atmosphere, gas, and/or smooth hydrophobic surface, and then collected.Type: GrantFiled: July 24, 1989Date of Patent: October 1, 1991Inventors: Richard B. Cook, Richard B. Provonchee, Samuel Nochumson
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Patent number: 4983268Abstract: Purified agarose suitable for rapid electrophoresis, characterized by a sulfate content of less than 0.2 wt % but greater than zero, a pyruvate content of 0-0.1 wt %, and a nitrogen content of 0-0.02 wt %. Gels prepared from the agarose exhibit a gel strength at 1.0 wt % concentration of at least 1200 g/cm.sup.2, substantial absence of DNA binding in 0.07 M or less tris acetate buffer, and an electroendosmosis (EEO) at 1.0 wt % concentration of 0.05 or less. Agaroses are purified to provide the low EEO material by dissolving agarose or alkali-modified agar in an aqueous medium buffered at a pH of 6.0 to 8.0 and containing no more than 2.0 nM salt as chloride, and precipitating the agarose by contact with a lower alkanol.Type: GrantFiled: August 3, 1989Date of Patent: January 8, 1991Assignee: FMC CorporationInventors: Francis H. Kirkpatrick, Kenneth Guiseley, Richard Provonchee, Samuel Nochumson
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Patent number: 4542200Abstract: An electrophoresis medium, comprising a copolymer of acrylamide and an ethylenically unsaturated resin formed by replacing at least some of the hydroxyl hydrogens in a polysaccharide with an ethylenically unsaturated group, is described.Type: GrantFiled: November 30, 1984Date of Patent: September 17, 1985Assignee: FMC CorporationInventor: Samuel Nochumson
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Patent number: 4504641Abstract: An electrophoresis medium, comprising a copolymer of acrylamide and an ethylenically unsaturated resin formed by replacing at least some of the hydroxyl hydrogens in a polysaccharide with an ethylenically unsaturated group, is described.Type: GrantFiled: October 17, 1983Date of Patent: March 12, 1985Assignee: FMC CorporationInventor: Samuel Nochumson
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Patent number: 4415428Abstract: An electrophoretic support comprising a base plate having on at least one side thereof, a layer of an adherent resin containing ethylenically unsaturated groups capable of undergoing copolymerization with acrylamide. The support provides excellent adhesion for polyacrylamide gels and other electrophoretic media such as agarose.Type: GrantFiled: January 27, 1982Date of Patent: November 15, 1983Assignee: FMC CorporationInventors: Samuel Nochumson, Henry J. Witt