Patents by Inventor Samuel Shanes

Samuel Shanes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated caul with elastomeric seals
    Patent number: 11993034
    Abstract: A method, apparatus, and system for applying a vacuum-based pressure on an uncured composite structure. Membranes are bonded to a boundary of a caul. The membranes include positive features that define vacuum channels. The membranes are spliced to each other. The positive features that define the vacuum channels in the membranes are aligned to each other during splicing of the membranes. The membranes spliced to each other and bonded to the caul to form an integrated caul. The integrated caul applies a pressure on the uncured composite structure during operation of the integrated caul.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: May 28, 2024
    Assignee: The Boeing Company
    Inventors: Samuel Shane Brickey, Julia Karolina Slusarski
  • INTEGRATED CAUL WITH ELASTOMERIC SEALS
    Publication number: 20230356485
    Abstract: A method, apparatus, and system for applying a vacuum-based pressure on an uncured composite structure. Membranes are bonded to a boundary of a caul. The membranes include positive features that define vacuum channels. The membranes are spliced to each other. The positive features that define the vacuum channels in the membranes are aligned to each other during splicing of the membranes. The membranes spliced to each other and bonded to the caul to form an integrated caul. The integrated caul applies a pressure on the uncured composite structure during operation of the integrated caul.
    Type: Application
    Filed: May 3, 2022
    Publication date: November 9, 2023
    Inventors: Samuel Shane Brickey, Julia Karolina Slusarski
  • 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)
    Patent number: 11807646
    Abstract: Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: November 7, 2023
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: James Samuel Shane Rountree, Steven Kristopher Whitehead, Adam Piotr Treder, Lauren Emma Proctor, Steven David Shepherd, Frank Burkamp, Joana Rita Castro Costa, Colin O'Dowd, Timothy Harrison
  • USP7 INHIBITOR FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20230088286
    Abstract: Provided herein are treatments for cancer by inhibition of USP7 activity, for example inhibition of USP7 activity in fibroblasts, inhibition of extra-cellular matrix remodelling in the tumour microenvironment, inhibition of VEGF, inhibition of angiogenesis or metastasis, modulation of the immune system, or a combination thereof.
    Type: Application
    Filed: February 12, 2021
    Publication date: March 23, 2023
    Inventors: Xavier JACQ, Ian Thomas LOBB, Mark WAPPETT, Anamarija JURISIC, James Samuel Shane ROUNTREE, Matthew Duncan HELM
  • PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)
    Publication number: 20220033397
    Abstract: Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those a compounds for use in methods of treating muscular atrophy.
    Type: Application
    Filed: December 6, 2019
    Publication date: February 3, 2022
    Inventors: James Samuel Shane ROUNTREE, Steven Kristopher WHITEHEAD, Adam Piotr TREDER, Lauren Emma PROCTOR, Steven David SHEPHERD, Frank BURKAMP, Joana Rita Castro COSTA, Colin O'DOWD, Timothy HARRISON, Matthew Duncan HELM, Ewelina ROZYCKA, Aaron CRANSTON, Xavier JACQ
  • USP19 INHIBITORS FOR USE IN THERAPY
    Publication number: 20220016115
    Abstract: Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.
    Type: Application
    Filed: December 6, 2019
    Publication date: January 20, 2022
    Inventors: James Samuel Shane ROUNTREE, Peter HEWITT, Mary Melissa MCFARLAND, Frank BURKAMP, Christina BELL, Colin O'DOWD, Timothy HARRISON, Matthew Duncan HELM, Ewelina ROZYKA, Aaron CRANSTON, Xavier JACQ, Lauren PROCTOR
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20220002264
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Application
    Filed: July 6, 2021
    Publication date: January 6, 2022
    Inventors: Peter HEWITT, Mary Melissa MCFARLAND, James Samuel Shane ROUNTREE, Frank BURKAMP, Christina BELL, Lauren PROCTOR, Matthew Duncan HELM, Colin O'DOWD, Timothy HARRISON
  • Pharmaceutical compounds
    Patent number: 11053213
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: July 6, 2021
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: Peter Hewitt, Mary Melissa McFarland, James Samuel Shane Rountree, Frank Burkamp, Christina Bell, Lauren Proctor, Matthew Duncan Helm, Colin O'Dowd, Timothy Harrison
  • 4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)
    Publication number: 20210070773
    Abstract: Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.
    Type: Application
    Filed: January 31, 2019
    Publication date: March 11, 2021
    Inventors: James Samuel Shane ROUNTREE, Steven Kristopher WHITEHEAD, Adam Piotr TREDER, Lauren Emma PROCTOR, Steven David SHEPHERD, Frank BURKAMP, Joana Rita Castro COSTA, Colin O'DOWD, Timothy HARRISON
  • Wee-1 inhibiting pyrazolopyrimidinone compounds
    Patent number: 10766902
    Abstract: The present invention relates to pyrazolopyrimidinone derivatives, such as those of Formula (I), that are useful as inhibitors of the activity of Wee-1 kinase.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: September 8, 2020
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: Frank Burkamp, James Samuel Shane Rountree, Adam Piotr Treder
  • WEE-1 INHIBITING PYRAZOLOPYRIMIDINONE COMPOUNDS
    Publication number: 20190248795
    Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
    Type: Application
    Filed: July 12, 2017
    Publication date: August 15, 2019
    Inventors: Frank BURKAMP, James Samuel Shane ROUNTREE, Adam Piotr TREDER
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20190233394
    Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.
    Type: Application
    Filed: July 26, 2017
    Publication date: August 1, 2019
    Applicant: Almac Discovery Limited
    Inventors: Peter HEWITT, Mary Melissa MCFARLAND, James Samuel Shane ROUNTREE, Frank BURKAMP, Christina BELL, Lauren PROCTOR, Matthew Duncan HELM, Colin O'DOWD, Timothy HARRISON
  • Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors
    Patent number: 9714244
    Abstract: The present invention relates to compounds of formula (I) that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: July 25, 2017
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: Colin Roderick O'Dowd, James Samuel Shane Rountree, Frank Burkamp, Andrew John Wilkinson
  • 2-AMINOPYRIDO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND THEIR USE AS WEE-1 INHIBITORS
    Publication number: 20160060258
    Abstract: The present invention relates to compounds of formula (I) that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Inventors: Colin Roderick O'Dowd, James Samuel Shane Rountree, Frank Burkamp, Andrew John Wilkinson
  • Pharmaceutical compounds
    Patent number: 8546376
    Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: October 1, 2013
    Assignee: Almac Discovery Limited
    Inventors: Mark Peter Bell, Timothy Harrison, Sumita Bhattacharyya, James Samuel Shane Rountree, Frank Burkamp, Stephen Price, Calum MacLeod, Richard Leonard Elliott, Phillip Smith, Toby Jonathan Blench, Colin Roderick O'Dowd, Lixin Zhang, Graham Peter Trevitt, Hazel Joan Dyke
  • Compact call station
    Patent number: D800087
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 17, 2017
    Assignee: TALK-A-PHONE COMPANY
    Inventors: Samuel Shanes, Clarence Wong, Khushroo Kali Patel, Jordan Karol, Joshua Ryan Skorich, Michael Douglas Prince, Tong Jin Kim, Christian Kulujian
  • Call station
    Patent number: D817299
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: May 8, 2018
    Assignee: TALK-A-PHONE CO.
    Inventors: Samuel Shanes, Clarence Wong, Khushroo Kali Patel, Jordan Karol, Joshua Ryan Skorich, Michael Douglas Prince, Tong Jin Kim, Christian Kulujian
  • Compact call station
    Patent number: D834555
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: November 27, 2018
    Assignee: TALK-A-PHONE COMPANY
    Inventors: Samuel Shanes, Clarence Wong, Khushroo Kali Patel, Jordan Karol, Joshua Ryan Skorich, Michael Douglas Prince, Tong Jin Kim, Christian Kulujian
  • Compact call station
    Patent number: D834556
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: November 27, 2018
    Assignee: TALK-A-PHONE CO.
    Inventors: Samuel Shanes, Clarence Wong, Khushroo Kali Patel, Jordan Karol, Joshua Ryan Skorich, Michael Douglas Prince, Tong Jin Kim, Christian Kulujian
  • Pedestal call station/kiosk
    Patent number: D844583
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: April 2, 2019
    Assignee: TALK-A-PHONE LLC
    Inventors: Khushroo Kali Patel, Samuel Shanes, Clarence Wong