Abstract: A method for performing measurements includes providing relative movement between a receptacle and a cover over a measurement interval comprising multiple non-overlapping time periods. A distance between the receptacle and the cover changes along a first axis over at least a portion of each time period. An apparatus for performing measurements includes a receptacle comprising a substrate and a plurality of wells within the substrate, and a cover. The cover includes: (1) a device configured to engage with the receptacle, (2) a control subsystem configured to provide relative movement between the receptacle and the cover, and (3) a measurement subsystem.

Abstract: Systems and method are provided for defining map data used in controlling a vehicle. In one embodiment, a method includes: receiving, by a processor, telemetry data; determining, by the processor, distribution data of a path based on the telemetry data; determining, by the processor, a plurality of sample data based on a trained machine learning model and the distribution data; generating, by the processor, at least one of lane line data and road edge data based on the sample data and a second machine learning model; and storing, by the processor, the map data including the lane line data and road edge data for use in controlling the vehicle.

Abstract: Systems and methods are provided for creating, managing and implementing data encryption and key management in a software application through an application programming interface (API) via a SAAS-based API-based platform. A developer can quickly and easily build encryption into any application with an API accessed through an API-based platform that allows the developer to enter basic information about an application, generate encryption keys, download a client library and implement the encryption into the application based on the application information and encryption keys with only two calls to the API. The encryption is built into the software layer and the keys are managed remotely, providing security and simplicity for implementing and executing encryption.

Abstract: A gaming device comprises a display, a random number generator, a processor, and a memory storing instructions. When the instructions are executed by the processor, they cause the processor to conduct a base game from which feature games and at least one composite feature game can be triggered, where the composite feature game comprises game play characteristics from a first feature game and a second feature game of the feature games, and the composite feature game comprises a combination of the different game play characteristics. The composite feature game is initiated in response to a composite feature trigger condition being met. The game instances are presented with one or more feature game icon, which are modified in presentation during the game instances in accordance with an associated game play characteristic for a particular instance.

Abstract: An integrated vehicle jacking assembly includes a plurality of jacks that is each coupled to a bottom side of a vehicle. Each of the jacks is actuatable into an extended position for lifting a respective driver's side or passenger's side of the vehicle upwardly thereby facilitating tires on the respective driver's side or passenger's side of the vehicle to be removed and replaced. A control unit is positioned within the vehicle and the control unit is operationally coupled to each of the jacks. The control unit actuates one or both of the jacks between the extended position and the retracted position. A plurality of wheel chocks is provided for inhibiting the vehicle from rolling when the vehicle is lifted.

Abstract: An integrated vehicle jacking assembly includes a plurality of jacks that is each coupled to a bottom side of a vehicle. Each of the jacks is actuatable into an extended position for lifting a respective driver's side or passenger's side of the vehicle upwardly thereby facilitating tires on the respective driver's side or passenger's side of the vehicle to be removed and replaced. A control unit is positioned within the vehicle and the control unit is operationally coupled to each of the jacks. The control unit actuates one or both of the jacks between the extended position and the retracted position. A plurality of wheel chocks is provided for inhibiting the vehicle from rolling when the vehicle is lifted.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: A method for performing measurements includes providing relative movement between a receptacle and a cover over a measurement interval comprising multiple non-overlapping time periods. A distance between the receptacle and the cover changes along a first axis over at least a portion of each time period. An apparatus for performing measurements includes a receptacle comprising a substrate and a plurality of wells within the substrate, and a cover. The cover includes: (1) a device configured to engage with the receptacle, (2) a control subsystem configured to provide relative movement between the receptacle and the cover, and (3) a measurement subsystem.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected.

Abstract: A variable arc sprinkler head or nozzle may be set to numerous positions to adjust the arcuate span of the sprinkler. The sprinkler head includes an arc adjustment valve having two portions that helically engage each other to define an opening that may be adjusted at the top of the sprinkler to a desired arcuate length. The arcuate length may be adjusted by pressing down and rotating a deflector to directly actuate the valve without the need for a hand tool. A method of irrigation is also provided involving moving the deflector between an arc adjustment position and an operational, irrigation position. The sprinkler head may also include a flow rate adjustment valve that may be adjusted by actuation or rotation of an outer wall portion of the sprinkler. Rotation of the outer wall portion causes a flow control member to move axially to or away from an inlet.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.

Abstract: A clock synthesizer uses a serializer to convert a parallel data stream into clock signals. The frequency of the synthesized clock is dependent on the bit values of the parallel data stream and the frequency of the reference clock used by the serializer. Rapid tuning of the frequency is provided by changing the bit values of the parallel data stream. Fine tuning of the frequency is provided by changing the frequency of the reference clock. With this configuration, the clock device is capable of generating clock signals with very low jitter, is tunable to a very fine resolution in frequency, is able to skew to an external trigger with no glitches, and is able to hop to different frequencies with minimal delays. Moreover, the clock device can be designed at fairly low cost, because the serializer is widely available as a component in telecommunications applications.