Abstract: This disclosure relates to scaffolds for inducing antibody responses against antigenic sites. In certain embodiments, this disclosure relates to compositions and methods using a filovirus sGP as a scaffold for inducing antibody responses against antigenic sites in foreign pathogens. In certain embodiments, this disclosure relates to compositions and methods using a filovirus sGP as a scaffold for inducing antibody responses against a virus to produce a viral vaccine.

Abstract: A mobile device can generate real-time complex visual image effects using asynchronous processing pipeline. A first pipeline applies a complex image process, such as a neural network, to keyframes of a live image sequence. A second pipeline generates flow maps that describe feature transformations in the image sequence. The flow maps can be used to process non-keyframes on the fly. The processed keyframes and non-keyframes can be used to display a complex visual effect on the mobile device in real-time or near real-time.

Abstract: A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities.

Abstract: In a method for controlling a cooking device, during operation of the cooking device at least one monitoring data is obtained, with a dimension of the monitoring data including at least one of a surface temperature of a cooked object, a weight of the cooked object, or a chamber temperature of the cooking device. The monitoring data is inputted to a preset regression model to obtain a predicted internal temperature of the cooked object, with the preset regression model representing a correlation between an internal temperature of the cooked object and the monitoring data. An operating status of the cooking device is adjusted according to at least the predicted internal temperature of the cooked object.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating speech from text. One of the systems includes one or more computers and one or more storage devices storing instructions that when executed by one or more computers cause the one or more computers to implement: a sequence-to-sequence recurrent neural network configured to: receive a sequence of characters in a particular natural language, and process the sequence of characters to generate a spectrogram of a verbal utterance of the sequence of characters in the particular natural language; and a subsystem configured to: receive the sequence of characters in the particular natural language, and provide the sequence of characters as input to the sequence-to-sequence recurrent neural network to obtain as output the spectrogram of the verbal utterance of the sequence of characters in the particular natural language.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: According to one aspect, a method includes obtaining a sensor assembly that includes at least a first camera and a second camera, and positioning the sensor assembly in an enclosure of a sensor testing system. The enclosure has a first enclosure target and a second enclosure target affixed thereon, and includes a sensor arrangement. The sensor testing assembly further includes a computing arrangement and a data acquisition arrangement, The method also includes performing a first test on the sensor assembly by providing commands to the sensor assembly using the computing arrangement, and monitoring the sensor assembly during the first test. Monitoring the sensor assembly includes obtaining data from the sensor assembly and/or the sensor arrangement, and providing the data to the data acquisition arrangement. Finally, the method includes processing the data, wherein processing the data includes determining whether the data indicates that the sensor assembly passes the first test.

Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.

Abstract: A method of making an anode material. The method begins by mixing a pre-passivated anode graphite with a supplement and a solvent to create a mixture. The solvent is then evaporated from the mixture to create a passivated anode graphite particle.

Abstract: A product-display system for displaying and securing a retail product. The system may include a retainer having a retainer bracket and a retainer body coupled to the retainer bracket. A retaining cable may be coupled to the retainer body at an opening in the retainer body. A fastener that may be unfastened to release the product from the retainer may only be accessed through the opening of the retainer body such that when the retaining cable is coupled to the opening, no fasteners of the retainer may be visible or accessible. The system may also include a display stem for holding the retainer and product. The display stem may include a recess for receiving at least a portion of the retainer body. The retaining cable may extend through the display stem and may simultaneously transmit power and data to a displayed product. The retainer may be returned to and held on top of the display stem using a retaining cable.

Abstract: A multi-sensor mounting system and method includes a secondary pipe and an adapter. The secondary pipe comprises a fastening device configured to fix the secondary pipe to the process pipe, and a valve that is switchable between an open state and a closed state. The adapter detachably connects a sensor module to the secondary pipe. The valve allows a sensing probe of the sensor module being inserted into the process pipe in the open state, and to block a fluid flow in the secondary pipe in the closed state, for example, for times when the sensing probe is removed from the secondary pipe.

Abstract: Methods for characterizing a population of microbes in a sample are described. The methods include: amplifying microbial polynucleotides obtained from the sample to form a plurality of amplicons and combining the amplicons with a plurality of microbeads, wherein each of the microbeads has a lanthanide spectral signature paired with the sequence of capture polynucleotides immobilized on the microbead. At least some of the capture polynucleotides comprise a sequence substantially complementary to a microbe-identifying sequence in one or more amplicons, such that at least some amplicons are captured onto beads by the capture polynucleotides and the microbe can be identified based on the lanthanide spectral signature of with which the capture polynucleotide is paired. Further described are methods for the identification of pathogens present in a sample by evaluating patterns of hybridization of a capture oligonucleotide to amplicons.

Abstract: A method for measuring the activity of one or more excitable cells, such as neurons, in a target tissue is provided. The present method may include measuring the activity of individual, selected excitable cells by projecting one or more three dimensional (3D) multi-focal laser light patterns into a target tissue containing excitable cells adapted to emit cellular electrical activity—sensitive fluorescence, to generate a multiplexed 2D diffraction pattern of fluorescence emitted by the neurons, and resolving the multiplexed 2D diffraction pattern. Also provided herein is a system configured to perform the present method, the system including a microscope configured to project one or more 3D multi-focal laser light patterns into a target tissue using a spatial light modulator and a mirror galvanometer, and a microlens array and an image detector to record individual and multiplexed 2D diffraction patterns of light emitted from the target tissue.

Abstract: Systems and methods for automatically correcting apparent distortions in close range photographs that are captured using an imaging system capable of capturing images and depth maps are disclosed. In many embodiments, faces are automatically detected and segmented from images using a depth-assisted alpha matting. The detected faces can then be re-rendered from a more distant viewpoint and composited with the background to create a new image in which apparent perspective distortion is reduced.

Abstract: Various aspects of the present disclosure are directed toward optics and imaging. As may be implemented with one or more embodiments, an apparatus includes one or more phase masks that operate with an objective lens and a microlens array to alter a phase characteristic of light travelling in a path from a specimen, through the objective lens and microlens array and to a photosensor array. Using this approach, the specimen can be imaged with spatial resolution characteristics provided via the altered phase characteristic, which can facilitate construction of an image with enhanced resolution.

Abstract: Systems and methods for automatically correcting apparent distortions in close range photographs that are captured using an imaging system capable of capturing images and depth maps are disclosed. In many embodiments, faces are automatically detected and segmented from images using a depth-assisted alpha matting. The detected faces can then be re-rendered from a more distant viewpoint and composited with the background to create a new image in which apparent perspective distortion is reduced.

Abstract: A method for measuring the activity of one or more excitable cells, such as neurons, in a target tissue is provided. The present method may include measuring the activity of individual, selected excitable cells by projecting one or more three dimensional (3D) multi-focal laser light patterns into a target tissue containing excitable cells adapted to emit cellular electrical activity—sensitive fluorescence, to generate a multiplexed 2D diffraction pattern of fluorescence emitted by the neurons, and resolving the multiplexed 2D diffraction pattern. Also provided herein is a system configured to perform the present method, the system including a microscope configured to project one or more 3D multi-focal laser light patterns into a target tissue using a spatial light modulator and a mirror galvanometer, and a microlens array and an image detector to record individual and multiplexed 2D diffraction patterns of light emitted from the target tissue.

Abstract: Systems and methods for automatically correcting apparent distortions in close range photographs that are captured using an imaging system capable of capturing images and depth maps are disclosed. In many embodiments, faces are automatically detected and segmented from images using a depth-assisted alpha matting. The detected faces can then be re-rendered from a more distant viewpoint and composited with the background to create a new image in which apparent perspective distortion is reduced.