Patents by Inventor Samy Meroueh

Samy Meroueh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolylacylpyrazoline compounds and method for treating pain
    Patent number: 11999720
    Abstract: This invention relates to pyrazolylacylpyrazoline compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat neurological disorders.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: June 4, 2024
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Samy Meroueh, Fletcher A. White, Alexander G. Obukhov
  • SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
    Publication number: 20240173291
    Abstract: Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
    Type: Application
    Filed: December 14, 2023
    Publication date: May 30, 2024
    Inventors: ELLIOT J. ANDROPHY, SAMY MEROUEH, ZHIJIAN LU, Anne RIETZ
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 11964985
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: April 23, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • Small molecule antiviral drug treatment for human papillomavirus infections
    Patent number: 11877999
    Abstract: Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
    Type: Grant
    Filed: September 26, 2022
    Date of Patent: January 23, 2024
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, KOVINA THERAPEUTICS, INC
    Inventors: Elliot J. Androphy, Samy Meroueh, Zhijian Lu, Anne Rietz
  • Small molecule antiviral drug treatment for human papillomavirus infections
    Patent number: 11628158
    Abstract: Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: April 18, 2023
    Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, KOVINA THERAPEUTICS, INC.
    Inventors: Elliot J. Androphy, Samy Meroueh, Zhijian Lu
  • SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
    Publication number: 20230047626
    Abstract: Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
    Type: Application
    Filed: September 26, 2022
    Publication date: February 16, 2023
    Inventors: ELLIOT J. ANDROPHY, SAMY MEROUEH, ZHIJIAN LU, Anne RIETZ
  • SMALL-MOLECULE COVALENT INHIBITION OF RAL GTPASES
    Publication number: 20230032020
    Abstract: Disclosed herein are Ral-antagonist compounds that covalently bind to binding sites in RalA, and efficaciously inhibit Ral activity. The compounds include aryl sulfonyl fluoride compounds of the general structure of wherein X and Y are independently C or N, and R4 is C1-C4 alkyl, —OCH3, —OCH2CH3, —OCH(CH3)2, —(SO2)CH3, —OH, or halo. These compounds expand Ral-inhibiting therapeutic options for treating Ral-driven cancers and one embodiment of the present disclosure is directed to the use of such compounds to treat cancer.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 2, 2023
    Inventors: Samy MEROUEH, Khuchtumur BUM-ERDENE, Giovanni GONZALEZ-GUTIERREZ
  • SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
    Publication number: 20220142973
    Abstract: Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
    Type: Application
    Filed: January 19, 2022
    Publication date: May 12, 2022
    Inventors: ELLIOT J. ANDROPHY, SAMY MEROUEH, ZHIJIAN LU, Anne RIETZ
  • COMPOUNDS AND METHODS TO ATTENUATE TUMOR PROGRESSION AND METASTASIS
    Publication number: 20210403415
    Abstract: This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), Formula (1a), or Formula (1b), or a pharmaceutically acceptable salt thereof, and at least one of a pharmaceutically acceptable carrier, diluent or excipient.
    Type: Application
    Filed: October 28, 2019
    Publication date: December 30, 2021
    Inventors: Samy MEROUEH, Khuchtumur BUM-ERDENE
  • PYRAZOLYLACYLPYRAZOLINE COMPOUNDS AND METHOD FOR TREATING PAIN
    Publication number: 20210155609
    Abstract: This invention relates to pyrazolylacylpyrazoline compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat neurological disorders.
    Type: Application
    Filed: September 19, 2019
    Publication date: May 27, 2021
    Inventors: Samy MEROUEH, Fletcher A. WHITE, Alexander G. OBUKHOV
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20200270263
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Samy MEROUEH, Martin A. SCHWARTZ, Phillip REIGAN
  • Anti-cancer compounds targeting ral GTPases and methods of using the same
    Patent number: 10689392
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: June 23, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20160280715
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: April 29, 2016
    Publication date: September 29, 2016
    Inventors: Dan THEODORESCU, Michael Fitzpatrick WEMPE, David ROSS, Samy MEROUEH, Martin A. SCHWARTZ, Phillip REIGAN
  • uPAR-uPA interaction inhibitors and methods for treating cancer
    Patent number: 9376406
    Abstract: The invention described herein pertains to compounds, compositions and formulations comprising the compounds, and methods for use of the compounds, compositions and/or formulations in the treatment of diseases responsive to the inhibition of uPAR-uPA interactions, such as cancer.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: June 28, 2016
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Samy Meroueh
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 9353121
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 31, 2016
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
    Publication number: 20140315894
    Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
    Type: Application
    Filed: December 21, 2012
    Publication date: October 23, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
  • uPAR-uPA INTERACTION INHIBITORS AND METHODS FOR TREATING CANCER
    Publication number: 20130338144
    Abstract: The invention described herein pertains to compounds, compositions and formulations comprising the compounds, and methods for use of the compounds, compositions and/or formulations in the treatment of diseases responsive to the inhibition of uPAR-uPA interactions, such as cancer.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 19, 2013
    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventor: Samy Meroueh