Abstract: Provided herein are controlled release gastro retentive dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile.

Abstract: Provided herein are controlled release multiparticulate dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile.

Abstract: Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time.

Abstract: Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time.

Abstract: Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time.

Abstract: Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time.

Abstract: Techniques for running diagnostic rules across multiple nodes are disclosed. A root cause of an error occurring on a particular node is determined. A root cause of an error on the particular node is identified based on a metric corresponding to another node and/or based on a previously-reported error on another node. Additionally or alternatively, an error is predicted to occur on a particular node. The error is predicted based on a trend associated with a metric corresponding to another node.

Abstract: Techniques for running diagnostic rules across multiple nodes are disclosed. A root cause of an error occurring on a particular node is determined. A root cause of an error on the particular node is identified based on a metric corresponding to another node and/or based on a previously-reported error on another node. Additionally or alternatively, an error is predicted to occur on a particular node. The error is predicted based on a trend associated with a metric corresponding to another node.

Abstract: Systems and methods are described for diagnosing behavior of software components in an application server. The application server can comprise a plurality of components that process incoming requests. A diagnostics advisor can be deployed with the application server and can determine an efficiency and/or inefficiency of each of the components of the application server or other middleware system. The efficiency determined by computing a ratio of the number of requests that completed execution during a particular sampling time period to the number of requests that were received. The inefficiency is the ratio of the number of requests that are still being executed at the end of the sampling time period to the number of requests that were received. The diagnostics advisor employs the determined efficiency and/or inefficiency to diagnose a misbehavior or other problem of the components in the application server.

Abstract: A system and method for providing a static model map of behaviors in a middleware system, for use in identifying problems. In accordance with an embodiment, the system provides a view of the system which allows for analysis of the various components. Locations within the system where a request spends its time are categorized into either “wait” or “execution” locations. The components exhibit static behaviors which affect the response time and can be predefined for different types of components and analyzed independently. In turn the behaviors can be classified as either “wait” or “execution”, each of which can be considered aspects of a component. Each aspect of a component must satisfy the same efficiency/inefficiency as defined by the requirements on the system. An aspect that does not meet the criteria is considered a “problem aspect” and is analyzed further to find the cause of the problem.

Abstract: Systems and methods are described for diagnosing behavior of software components in an application server. The application server can comprise a plurality of components that process incoming requests. A diagnostics advisor can be deployed with the application server and can determine an efficiency and/or inefficiency of each of the components of the application server or other middleware system. The efficiency determined by computing a ratio of a number of requests that completed execution in the component during a particular sampling time period to the number of requests that were received by the component during the sampling time period. The inefficiency is the inverse of efficiency, i.e. it is a ratio of the number of requests that are still being executed by the one or more components at the end of the sampling time period to the number of requests that were received by the one or more components during the sampling time period.

Abstract: A system and method for providing a static model map of behaviors in a middleware system, for use in identifying system problems. In accordance with an embodiment, the system provides a view of the system, such as a middleware system, which allows for analysis of the various components involved, such that analysis of one component does not affect the analysis of a second component. Locations within the middleware system where a particular request spends its time before returning a response are broadly categorized into either “wait” or “execution” locations. Irrespective of which request calls a component, the components exhibit the same behaviors which affect the response time of the request serviced. These exhibited behaviors are static and can be predefined for different types of components and analyzed independently of each other. In turn the behaviors can be similarly classified as either “wait” or “execution”, each of which can be considered aspects of a component.

Abstract: The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.

Abstract: The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.