Abstract: A method, system, and article of manufacture provide for multi-user collaboration on a three-dimensional (3D) design. The 3D design is acquired in a computer-aided design (CAD) application. A commenting process for a comment to be associated with a selected part of the 3D design is activated. Textual user input for the comment is dynamically processed as the comment is received. The processing recognizes that the text relates to creating or modifying the selected part, retrieves a list of alternative parts (based on similarities between the alternative parts and the selected part), and displays a graphic representation of an alternative part. An alternative part is selected and inserted in the comment as a proposed replacement part. The comment including the proposed replacement part is provided to another user.

Abstract: Disclosed systems and methods include executing a convolutional neural network to detect a level of microbiome in a whole slide image associated with a patient, based on an output of the convolutional neural network, categorize the whole slide image as one of microbiome-low and microbiome-high, and, based on the categorization of the whole slide image, determine a characteristic of a cancer associated with the patient.

Abstract: A multi-layered pharmaceutical delivery system is contemplated in which the delivery of medicaments to patients is controlled via the sequential delivery of medicaments contained within ingestible solid pharmaceutical layers, preferably frozen in a media that liquefies following ingestion by a patient so as to release the medicament when ingested by melting. A frozen ice pop embodiment is contemplated to contain an outermost ingestible pharmaceutical layer enclosing further ingestible pharmaceutical layers sequentially enclosed within that inner pharmaceutical layer. Other embodiments are contemplated in which the layers are linearly sequenced within an external container that prevents ingestion of the subsequent layers until the prior layers have been ingested.

Abstract: The inventive subject matter provides a modular mattress system wherein the mattress surface may be adjusted for positioning of a user's body. The mattress system deploys a number of interconnected mattress cells. The mattress cells may have varying characteristics, and combinations of mattress cells may be interconnected to form a complete mattress. The proximal surface is formed of padding material and collectively form the entire mattress surface when connected. At least one actuator is mechanically coupled to padding material and an actuator controller in communication therewith directs movement of the actuator to position the padding material. A mattress cell communication interface is communicably coupled to the actuator controller and configured to communicably couple with at least one external device.

Abstract: A multi-layered pharmaceutical delivery system is contemplated in which the delivery of medicaments to patients is controlled via the sequential delivery of medicaments contained within ingestible solid pharmaceutical layers, preferably frozen in a media that liquefies following ingestion by a patient so as to release the medicament when ingested by melting. A frozen ice pop embodiment is contemplated to contain an outermost ingestible pharmaceutical layer enclosing further ingestible pharmaceutical layers sequentially enclosed within that inner pharmaceutical layer. Other embodiments are contemplated in which the layers are linearly sequenced within an external container that prevents ingestion of the subsequent layers until the prior layers have been ingested.

Abstract: The inventive subject matter provides a modular mattress system wherein the mattress surface may be adjusted for positioning of a user's body. The mattress system deploys a number of interconnected mattress cells. The mattress cells may have varying characteristics, and combinations of mattress cells may be interconnected to form a complete mattress. The proximal surface is formed of padding material and collectively form the entire mattress surface when connected. At least one actuator is mechanically coupled to padding material and an actuator controller in communication therewith directs movement of the actuator to position the padding material. A mattress cell communication interface is communicably coupled to the actuator controller and configured to communicably couple with at least one external device.