Abstract: A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (I) or its saltR.sup.1 means amino-, hydroxyl-, --NH-phenyl or --NH--CO--NH.sub.2 groups,R.sup.2 means a hydrogen atom or a hydroxyl group.The invention also covers a process for selective blocking the opioid binding sites of the brain responsible for respiratory depression by administering to a patient in need of an analgetic a preparation containing a codeinone derivative of general formula (I) or its salt preferably three times per day in doses of 2.5-5 mg.

Abstract: A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (I) or its saltR.sup.1 means amino--, hydroxyl--, --NH--phenyl or --NH--CO--NH.sub.2 groups,R.sup.2 means a hydrogen atom or a hydroxyl group.The invention also covers a process for selective blocking the opioid binding sites of the brain responsible for respiratory depression by administering to a patient in need of an analgetic a preparation containing a codeinone derivative of general formula (I) or its salt preferably three times per day in doses of 2,5-5 mg.

Abstract: The present invention relates to novel morphinane-skeletoned compounds of the formula (I) ##STR1## wherein Y in-NH phenyl or --NH dintro phenyl, Z is --CH.sub.2 -- CH.sub.2, R.sub.2 is hydroxyl and R.sub.3 is H or methyl, the steric isomers and the pharmaceutically acceptable salts thereof, a novel process for producing the same and pharmaceutical compositions comprising the same as active ingredients.The novel compounds can be used in the therapy as analgetic or morphine-antagonistic agents.

Abstract: The invention relates to a process for the preparation of DL-.beta.-aryl-amino acids of the general Formula ##STR1## wherein R, R.sub.1 and R.sub.2 stand for hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro or C.sub.1-4 dialkylamino; wherebyin the case of monosubstituted derivatives R and R.sub.1 are hydrogen and R.sub.2 has the same meaning as stated above and can be attached to position 2, 3 or 4 related to the methylene group;in the case of disubstituted derivatives R is hydrogen and R.sub.1 and R.sub.2 have the same meaning as stated above and are attached to positions 2,3; 2,4; 2,5; 2,6; 3,4 or 3,5 related to the methylene group;in the case of trisubstituted derivatives R, R.sub.1 and R.sub.2 have the same meaning as stated above and are attached to positions 2,3,4; 2,3,5; 2,3,6; 3,4,5 or 3,4,6 related to the methylene group.