Patents by Inventor Sandra Larkin

Sandra Larkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
    Patent number: 11660286
    Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: May 30, 2023
    Assignee: EPICENTRX, INC.
    Inventors: Bryan T. Oronsky, Jan Scicinski, Susan Knox, William Fitch, Frans A. Kuypers, Marcel Fens, Sandra Larkin, Pedro Cabrales, Chad Brouse
  • METHODS AND COMPOSITIONS COMPRISING A NITRITE-REDUCTASE PROMOTER FOR TREATMENT OF MEDICAL DISORDERS AND PRESERVATION OF BLOOD PRODUCTS
    Publication number: 20200022952
    Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
    Type: Application
    Filed: February 25, 2019
    Publication date: January 23, 2020
    Inventors: Bryan T. Oronsky, Jan Scicinski, Susan Knox, William Fitch, Frans A. Kuypers, Marcel Fens, Sandra Larkin, Pedro Cabrales, Chad Brouse
  • METHODS AND COMPOSITIONS COMPRISING A NITRITE-REDUCTASE PROMOTER FOR TREATMENT OF MEDICAL DISORDERS AND PRESERVATION OF BLOOD PRODUCTS
    Publication number: 20140308260
    Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
    Type: Application
    Filed: October 5, 2012
    Publication date: October 16, 2014
    Inventors: Bryan T. Oronsky, Jan Scicinski, Susan Knox, William Fitch, Frans A. Kuypers, Marcel Fens, Sandra Larkin, Pedro Cabrales, Chad Brouse