Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Abstract: Disclosed is a method of diagnosing and treating a head neck cancer characterized by expressing a tumor-associated antigen having the amino acid sequence shown in SEQ ID NO:4. The method comprises treating the so-affected patient with an antibody which specifically binds to an extracellular portion of said tumor-associated antigen having the amino acid sequence of SEQ ID NO: 4.

Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Abstract: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.

Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

Abstract: The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

Abstract: In a method for loading software into a target appliance in a vehicle control system having a plurality of appliance, the loading process for one or more software modules is subdivided into task elements (at least one monitoring appliance task, one update appliance task and one receiving appliance task), and performance of the respective task elements is assigned to the target appliance, other appliances and/or to a control appliance outside the vehicle control system. The monitoring appliance task includes processing and passing on the control commands for the loading of the software module from outside the vehicle control system; the update appliance task includes controlling the loading of the software module between the target appliance, the appliances and/or the control appliance; and the receiving appliance task includes provision of an interface for the software module which is to be loaded from outside the vehicle control system.

Abstract: A vehicle communication system has at least one processor unit (1), arranged in the vehicle, for controlling applications, a plurality of different data sources (2, 4, 5, 6, 8) which are connected to the processor unit (1), and a plurality of operator consoles (9) which are connected to the processor unit (1). Access rights with different degrees of priority to the applications are allocated to the individual operator consoles (9).

Abstract: A method for documentation of data for a vehicle, with the data being stored in a data memory (2) in the vehicle (1), the data in the data memory (2) being updated in the event of changes, and this data being transmitted via a wireless data transmission device (4) to a control center (5) outside the vehicle (1), in which case the control center (5), triggered by an initiation signal, passes on the data to a configuration documentation server (7), the data is stored in a database (6), in particular in a chronological sequence and broken down into products, in order to record the configuration standard outside the vehicle (1) for replacement of products on the vehicle (1).

Abstract: A vehicle communication system with display and operator control unit, and having a data bus and components connected thereto, including at least one display/operator control unit and a computing unit which controls the latter. A graphic user interface, which is based on the HTML/XML page format, is implemented in the at least one display/operator control unit and/or the computing unit.

Abstract: The invention relates to a method for loading software into a target appliance in a vehicle control system having a number of appliances.

Abstract: A vehicle communications system, in particular for a motor vehicle, is provided having a plurality of equipment units for transmitting, receiving, acquiring and/or processing data for executing applications. The equipment units are connected to a common data bus via associated hardware interfaces. The applications are assigned flexibly controllable functions, each function being respectively assigned a software interface for exchanging data with other software interfaces and/or hardware interfaces, and the functions being executed within any desired equipment unit.

Abstract: A method for documentation of data for a vehicle, with the data being stored in a data memory (2) in the vehicle (1), the data in the data memory (2) being updated in the event of changes, and this data being transmitted via a wireless data transmission device (4) to a control center (5) outside the vehicle (1), in which case the control center (5), triggered by an initiation signal, passes on the data to a configuration documentation server (7), the data is stored in a database (6), in particular in a chronological sequence and broken down into products, in order to record the configuration standard outside the vehicle (1) for replacement of products on the vehicle (1).