Patents by Inventor Sandra Socarras
Sandra Socarras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9567622Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.Type: GrantFiled: June 4, 2015Date of Patent: February 14, 2017Assignee: Beckman Coulter, Inc.Inventors: Wayne Goldson, Sandra Socarras
-
Publication number: 20160002698Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.Type: ApplicationFiled: June 4, 2015Publication date: January 7, 2016Inventors: Wayne Goldson, Sandra Socarras
-
Patent number: 9091677Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.Type: GrantFiled: August 9, 2010Date of Patent: July 28, 2015Assignee: Beckman Coulter, Inc.Inventors: Wayne Goldson, Sandra Socarras
-
Publication number: 20120034640Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.Type: ApplicationFiled: August 9, 2010Publication date: February 9, 2012Applicant: Beckman Coulter, Inc.Inventors: Wayne Goldson, Sandra Socarras
-
Patent number: 7354767Abstract: A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.Type: GrantFiled: March 16, 2006Date of Patent: April 8, 2008Assignee: Beckman Coulter, Inc.Inventors: Nery Ortiz, Theodore J. Gerula, Sandra Socarras
-
Patent number: 7285417Abstract: A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.Type: GrantFiled: October 30, 2006Date of Patent: October 23, 2007Assignee: Beckman Coulter Inc.Inventors: Nery Ortiz, Sandra Socarras
-
Publication number: 20070218558Abstract: A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.Type: ApplicationFiled: March 16, 2006Publication date: September 20, 2007Applicant: Beckman Coulter, Inc.Inventors: Nery Ortiz, Theodore Gerula, Sandra Socarras
-
Patent number: 7198953Abstract: Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component is made of stabilized or processed nucleated blood cells which have impedance and optical properties simulating the impedance and optical properties of human nucleated red blood cells under a blood lysing condition as measured by a specific measurement. The methods include mixing the reference control composition with a lytic reagent, and analyzing the control sample mixture on a flow cytometric instrument by impedance, impedance and optical measurement, or DC impedance and a multi-dimensional measurement of light scatter, radio frequency and a second DC impedance; and reporting the simulated nucleated red blood cells in the reference control composition.Type: GrantFiled: October 7, 2004Date of Patent: April 3, 2007Assignee: Beckman Coulter, Inc.Inventors: Nery Ortiz, Jing Li, Yi Li, Sandra Socarras
-
Publication number: 20070072298Abstract: A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.Type: ApplicationFiled: October 30, 2006Publication date: March 29, 2007Applicant: BECKMAN COULTER, INC.Inventors: Nery Ortiz, Sandra Socarras
-
Patent number: 7135341Abstract: A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.Type: GrantFiled: March 30, 2005Date of Patent: November 14, 2006Assignee: Beckman Coulter, Inc.Inventors: Nery Ortiz, Sandra Socarras
-
Publication number: 20050227359Abstract: A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable for simulating nucleated red blood cells on a blood analyzer; and suspending treated blood cell in a suspension medium to form a reference control. The method also includes integrating the nucleated red blood cell component with white blood cell, red blood cell, platelet and reticulocyte components. Further disclosed is a cell treatment composition for altering a nucleus property, which includes a conditioning component, a lytic component for permeating cell membrane, and a fixing component for preserving the cell nucleus. Also disclosed is a method of using the reference control for measurement of nucleated red blood cells on a blood analyzer.Type: ApplicationFiled: March 30, 2005Publication date: October 13, 2005Applicant: Beckman Coulter, Inc.Inventors: Nery Ortiz, Sandra Socarras
-
Publication number: 20050079623Abstract: Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component is made of stabilized or processed nucleated blood cells which have impedance and optical properties simulating the impedance and optical properties of human nucleated red blood cells under a blood lysing condition as measured by a specific measurement. The methods include mixing the reference control composition with a lytic reagent, and analyzing the control sample mixture on a flow cytometric instrument by impedance, impedance and optical measurement, or DC impedance and a multi-dimensional measurement of light scatter, radio frequency and a second DC impedance; and reporting the simulated nucleated red blood cells in the reference control composition.Type: ApplicationFiled: October 7, 2004Publication date: April 14, 2005Applicant: Beckman Coulter, Inc.Inventors: Nery Ortiz, Jing Li, Yi Li, Sandra Socarras
-
Publication number: 20040132208Abstract: A method for utilizing a filtration device for removing interferants from a test sample containing a mixture of a composition of interest and interferants in an automated apparatus is disclosed. The filtration device includes a microporous hollow fiber membrane having a plurality of pores sized to retain the composition of interest while allowing smaller diameter interferants to pass through the membrane.Type: ApplicationFiled: December 19, 2003Publication date: July 8, 2004Applicant: Coulter International Corp.Inventors: Alexander Burshteyn, John W. Joubran, Nazle Kuylen, Frank J. Lucas, Carlos L. Aparicio, Michael L. Bell, Ravinder Gupta, Maria Elena Insausti, Jack D. McNeal, Paul W. Price, Sandra Socarras
-
Patent number: 6692968Abstract: A method for utilizing a filtration device for removing interferants from a test sample containing a mixture of a composition of interest and interferants in an automated apparatus is disclosed. The filtration device includes a microporous hollow fiber membrane having a plurality of pores sized to retain the composition of interest while allowing smaller diameter interferants to pass through the membrane.Type: GrantFiled: September 20, 2001Date of Patent: February 17, 2004Assignee: Coulter International Corp.Inventors: Alexander Burshteyn, John W. Joubran, Nazle Kuylen, Frank J. Lucas, Carlos L. Aparicio, Michael L. Bell, Ravinder Gupta, Maria Elena Insausti, Jack D. McNeal, Paul W. Price, Sandra Socarras
-
Publication number: 20020123154Abstract: A method for utilizing a filtration device for removing interferants from a test sample containing a mixture of a composition of interest and interferants in an automated apparatus is disclosed. The filtration device includes a microporous hollow fiber membrane having a plurality of pores sized to retain the composition of interest while allowing smaller diameter interferants to pass through the membrane.Type: ApplicationFiled: September 20, 2001Publication date: September 5, 2002Inventors: Alexander Burshteyn, John W. Joubran, Nazle Kuylen, Frank J. Lucas, Carlos L. Aparicio, Michael L. Bell, Ravinder Gupta, Maria Elena Insausti, Jack D. McNeal, Paul W. Price, Sandra Socarras