Patents by Inventor Sanford Markowitz

Sanford Markowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240174688
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 30, 2024
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH
    Publication number: 20240100026
    Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: May 11, 2023
    Publication date: March 28, 2024
    Inventors: Sanford MARKOWITZ, Joseph READY, Andrew PIEPER
  • METHODS OF DETECTING HIGH RISK BARRETT'S ESOPHAGUS WITH DYSPLASIA, AND ESOPHAGEAL ADENOCARCINOMA
    Publication number: 20240068033
    Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.
    Type: Application
    Filed: January 14, 2022
    Publication date: February 29, 2024
    Inventors: Sanford Markowitz, Amitabh Chak, Helen Moinova, Joseph Willis, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettewgowda, Christopher Douville
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240043440
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: November 21, 2022
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, Monika Antczak, Joseph Ready, Yongyou Zhang
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20240043443
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monica Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY
    Publication number: 20240024297
    Abstract: A method for preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: March 29, 2023
    Publication date: January 25, 2024
    Inventors: Sanford Markowitz, Ki Beom Bae, Hye Jung Kim, Sun-Hee Kim
  • COMBINATIONS OF 15-PGDH INHIBITORS WITH CORTICOSTEROIDS AND/OR TNF INHIBITORS AND USES THEREOF
    Publication number: 20230355636
    Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 9, 2023
    Inventors: Sanford Markowitz, Won Jin Ho, Stephen P. Fink, Vinay Varadan
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE
    Publication number: 20230322684
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: June 9, 2023
    Publication date: October 12, 2023
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING NEURODEGENERATION
    Publication number: 20230310390
    Abstract: A method of treating neurodegeneration and/or neurodegenerative condition, disease, or disorder caused by and/or associated with elevated or aberrant 15-PGDH activity in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 9, 2021
    Publication date: October 5, 2023
    Inventors: Sanford Markowitz, Andrew Pieper, Hongyun Li, Edwin Vazquez Rosa, Min-Kyoo Shin, Yeojung Koh, Joseph Ready
  • Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Publication number: 20230285402
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Compositions and methods of modulating short-chain dehydrogenase
    Patent number: 11718589
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 8, 2023
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
    Patent number: 11690847
    Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: July 4, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Sanford Markowitz, Won Jin Ho, Stephen P. Fink, Vinay Varadan
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230192717
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 22, 2023
    Inventors: Stephen L Gwaltney, Joseph Ready, Monika Antczak, Sanford Markowitz, Amar Desai, Stanton Gerson
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING CORONARY DISORDERS
    Publication number: 20230165883
    Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 23, 2022
    Publication date: June 1, 2023
    Inventors: Sanford Markowitz, Won Jin Ho, Yiyuan Yuan, Mukesh Jain, Mohamad Sabeh, Joseph Ready, Noelle Williams
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230136730
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: August 2, 2022
    Publication date: May 4, 2023
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS
    Publication number: 20230116062
    Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
    Type: Application
    Filed: August 30, 2022
    Publication date: April 13, 2023
    Inventors: Sanford Markowitz, Amar Desai, Joseph Ready
  • COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY
    Publication number: 20230052363
    Abstract: A method for preventing or treating renal disorder, disease, and/or injury includes administering to the subject and/or kidney a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 22, 2022
    Publication date: February 16, 2023
    Inventors: SANFORD MARKOWITZ, SUN-HEE KIM, HYE JUNG KIM, KIBEOM BAE
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230039604
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: November 21, 2019
    Publication date: February 9, 2023
    Inventors: Sanford MARKOWITZ, Joseph READY, Stephen L. GWALTNEY, II, Monika ANTCZAK
  • BIOLOGICAL SAMPLING DEVICE AND METHOD OF USE
    Publication number: 20230000474
    Abstract: Provided herein are methods and a device for collecting biological samples from a subject. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 5, 2023
    Applicant: Case Western Reserve University
    Inventors: Sanford Markowitz, Amitabh Chak, Joseph Willis
  • BIOLOGICAL SAMPLING DEVICE AND METHOD OF USE
    Publication number: 20230000475
    Abstract: Provided herein are methods and a device for collecting biological samples. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 5, 2023
    Applicant: Case Western Reserve University
    Inventors: Sanford Markowitz, Amitabh Chak, Joseph Willis, Lishan Aklog, Richard Yazbeck, Michael Boutillette, Brian deGuzman, David Wurtman