Patents by Inventor Sang Hee Shim

Sang Hee Shim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device and method for measuring central location of single molecule using structured illumination and phase detection
    Patent number: 11550136
    Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: January 10, 2023
    Assignees: Korea University Research and Business Foundation, INSTITUTE FOR BASIC SCIENCE
    Inventors: Sang Hee Shim, Ji Woong Kwon
  • DEVICE AND METHOD FOR MEASURING CENTRAL LOCATION OF SINGLE MOLECULE USING STRUCTURED ILLUMINATION AND PHASE DETECTION
    Publication number: 20210191098
    Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.
    Type: Application
    Filed: October 16, 2018
    Publication date: June 24, 2021
    Applicants: Korea University Research and Business Foundation, Institute for Basic Science
    Inventors: Sang Hee SHIM, Ji Woong KWON
  • N-acetylglucosamine-2-epimerase and method for producing CMP-neuraminic acid using the same
    Patent number: 8852891
    Abstract: The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: October 7, 2014
    Assignee: Gene Chem, Inc.
    Inventors: Jin Suk Woo, Jae Kyung Sohng, Byung Gee Kim, Sun Youp Kang, Dea Hee Kim, Kyoung Soon Jang, Ji Young Yang, Young Soo Jung, Won Min Seo, Tae Geon Gil, Sang Hee Shim, In Kang Hur
  • NOVEL N-ACETYLGLUCOSAMINE-2-EPIMERASE AND METHOD FOR PRODUCING CMP-NEURAMINIC ACID USING THE SAME
    Publication number: 20110287488
    Abstract: The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a large amount through a one-step reaction using cytidine monophosphate and N-acetyl-D-glucosamine which are inexpensive substrates.
    Type: Application
    Filed: December 7, 2007
    Publication date: November 24, 2011
    Applicant: GENE CHEM INC.
    Inventors: Jin Suk Woo, Jae Kyung Sohng, Byung Gee Kim, Sun Youp Kang, Dea Hee Kim, Kyoung Soon Jang, Ji Young Yang, Young Soo Jung, Won Min Seo, Tae Geon Gil, Sang Hee Shim, In Kang Hur