Abstract: The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same. Specifically, the insulinotropic peptide derivative is characterized in that the N-terminal positive charge of the insulinotropic peptide is modified to a neutral or net negative charge at neutral pH. The insulinotropic peptide derivative according to the present invention is rapidly dissociated from the GLP-1 receptor owing to the above modification in the N-terminal charge, and exhibits enhanced insulinotropic ability and blood glucose-lowering activity compared to the native insulinotropic peptide while maintaining its stability in blood. Accordingly, the insulinotropic peptide derivative of the present invention is very useful for the treatment of type 2 diabetes.

Abstract: The present invention relates to a top nozzle and a nuclear reactor in which an in-core instrument, which is supposed to be inserted through a top head of a nuclear reactor, is inserted through a guide pin for an upper core plate. In a nuclear reactor including guide pins for aligning a top nozzle for a nuclear fuel assembly with an upper core plate of a nuclear reactor, a guide hole (210) is axially formed through the guide pins (200) and in-core instruments (10) are inserted through the guide holes (210).

Abstract: An operating method of a semiconductor device includes monitoring multiple request packets and multiple response packets that are being transmitted between a master device and a slave device. A target request packet that matches predefined identification (ID) information is detected from among the request packets. An operation of a latency counter is initiated. The operation is for measuring the latency of a communication exchange (transaction) that includes the target request packet and a target response packet that is one of the response packets that matches the predefined ID information. The target response packet is detected from among the response packets. The operation of the latency counter is terminated. A latency value of the communication exchange is acquired from the latency counter.

Abstract: A method of manufacturing a semiconductor device includes forming a plurality of fins by forming a plurality of first device isolating trenches repeated at a first pitch in a substrate, forming a plurality of fin-type active areas protruding from a top surface of a first device isolating layer by forming the first device isolating layer in the plurality of first device isolating trenches, forming a plurality of second device isolating trenches at a pitch different from the first pitch by etching a portion of the substrate and the first device isolating layer, and forming a second device isolating layer in the plurality of second device isolating trenches, so as to form a plurality of fin-type active area groups separated from each other with the second device isolating layer therebetween.

Abstract: A wireless power reception device and a wireless communication method thereby are provided. The wireless communication method by the wireless power reception device may comprise the steps of: receiving a wireless power signal from a wireless power transmission device; measuring the strength of the wireless power signal; modulating the amplitude of the wireless power signal according to the measured strength of the wireless power signal; and performing communication with the wireless power transmission device by using the signal having the amplitude modulated.

Abstract: A composition for preventing or treating diabetes mellitus includes insulin and a GLP-1/glucagon dual agonist. The composition can inhibit the weight gain and reduce the danger of hypoglycemia due to the administration of insulin, lower the administration dose and greatly improve the compliance of drugs through a combined administration of a long-acting insulin conjugate and a long-acting GLP-1/glucagon dual agonist conjugate. In addition, the long-acting insulin conjugate and the long-acting GLP-1/glucagon dual agonist conjugate can improve the in vivo sustainability and stability because an insulin and a GLP-1/glucagon dual agonist are linked to the immunoglobulin Fc region via a non-peptidyl linker. A method for preventing or treat diabetes mellitus includes administration of the insulin and a GLP-1/glucagon dual agonist.

Abstract: A wireless power reception device and a wireless communication method thereby are provided. The wireless communication method by the wireless power reception device may comprise the steps of: receiving a wireless power signal from a wireless power transmission device; measuring the strength of the wireless power signal; modulating the amplitude of the wireless power signal according to the measured strength of the wireless power signal; and performing communication with the wireless power transmission device by using the signal having the amplitude modulated.

Abstract: The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same. Specifically, the insulinotropic peptide derivative is characterized in that the N-terminal positive charge of the insulinotropic peptide is modified to a neutral or net negative charge at neutral pH. The insulinotropic peptide derivative according to the present invention is rapidly dissociated from the GLP-1 receptor owing to the above modification in the N-terminal charge, and exhibits enhanced insulinotropic ability and blood glucose-lowering activity compared to the native insulinotropic peptide while maintaining its stability in blood. Accordingly, the insulinotropic peptide derivative of the present invention is very useful for the treatment of type 2 diabetes.

Abstract: A touch panel includes a touch electrode disposed on a substrate, the touch electrode including a metal layer; a phase matching layer disposed on the metal layer; and a thin film layer disposed on the phase matching layer.

Abstract: A display substrate includes a pixel switching element, a pixel electrode, a reference line, a control switching element, a bias line, a light sensing element, a sensing capacitor and a light blocking filter pattern. The pixel switching element is connected to a data line and a gate line, includes a first semiconductor pattern. The pixel electrode is connected to the pixel switching element. The reference line is in parallel with the data line. The control switching element is connected to the reference line and the gate line, includes a second semiconductor pattern. The bias line is in parallel with the gate line. The light sensing element is connected to the bias line and the control switching element, includes a third semiconductor pattern. The sensing capacitor is connected to the light sensing element and a storage line. The light blocking filter pattern transmits a first light, and blocks a second light.

Abstract: The present invention relates to an insulin analog that has reduced insulin receptor binding affinity for the purpose of increasing the blood half-life of insulin, and long-acting insulin, a conjugate, and a method of preparing long-acting insulin using the same.

Abstract: A first protective layer, a mask layer, a second protective layer and a photoresist layer are sequentially formed on a substrate. A photoresist pattern is formed by partially removing the photoresist layer. An ion implantation mask is formed by sequentially etching the second protective layer, the mask layer and the first protective layer using the photoresist pattern. The ion implantation mask exposes the substrate. Impurities are implanted in an upper portion of the substrate exposed by the ion implantation mask.

Abstract: An auto focusing lens includes an active lens including a lens body including electroactive polymer and a transparent electrode at least partially coated on a surface of the lens body, and a controller controlling the focus of the active lens by applying a voltage to the transparent electrode.

Abstract: A touch panel, a display device having the same, and a method of manufacturing the touch panel are disclosed. In one aspect, the touch panel includes a base substrate and a first sensing portion extending in a first direction and formed over the base substrate. The first sensing portion including a plurality of first fine lines defining a plurality of spaces therebetween. The touch panel also includes a second sensing portion extending in a second direction crossing the first direction and formed over the base substrate and a first insulating layer covering the first fine lines. The first insulating layer defines a plurality of openings therein corresponding to the spaces between the first fine lines. The second sensing portion crosses the first sensing portion with the first insulating layer interposed therebetween.

Abstract: A display device includes a lower display panel, an upper display panel facing the lower display panel, a metal oxide layer surrounding outermost surfaces of the upper display panel and the lower display panel, and a barrier layer surrounding the metal oxide layer. The barrier layer includes a self-assembled monolayer.

Abstract: A touch panel includes a substrate, a first signal line, and a second signal line. The first signal line extends on the substrate in a first direction and includes a first height from the substrate. The second signal line extends on the substrate in a second direction crossing the first direction and includes a second height from the substrate. The second signal line is disposed in the same layer as the first signal line. The second height is greater than the first height.

Abstract: A vehicle detecting system and method are provided. The method includes creating, by a controller, a disparity map using images photographed by a stereoscopic imaging device and detecting a road area on the disparity map. In addition, the controller is configured to detect a vehicle present in the road area in a shape of a stereoscopic object.

Abstract: Provided are a touch screen panel and a method of manufacturing the same. The touch screen panel comprises: a substrate; a first reflection-preventing film formed on the substrate; a first gate wiring formed on the first reflection-preventing film; and a sensing wiring formed above the first gate wiring to be insulated from the first gate wiring and to cross the first gate wiring.

Abstract: A method of forming a transparent 3D object and a transparent 3D object formed by the method are provided. A transparent 3D object may be formed as follows. An internal structure of a 3D object is printed using a 3D printer based on a 3D image file having information about an internal region of the 3D object, and a mold, designed to form the 3D object and divided into at least two regions, is printed using the 3D printer based on the 3D image file. Then, the internal structure is combined with an inner region of the mold, and a transparent material is supplied to the mold. After the transparent material hardens, a transparent 3D object is obtained by removing the mold.

Abstract: A display device including a display panel including pixels, and a touch sensor disposed on the display pane. The touch sensor includes a touch substrate, sensing electrodes disposed on the touch substrate, a passivation layer covering the sensing electrodes on the touch substrate and a first low refractive layer disposed between the touch substrate and the passivation layer, and having a refractive index lower than a refractive index of the passivation layer.