Patents by Inventor Sanjay R. Chemburkar

Sanjay R. Chemburkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20210087592
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: May 11, 2020
    Publication date: March 25, 2021
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • High purity oritavancin and method of producing same
    Patent number: 10864249
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: December 15, 2020
    Assignees: MELINTA THERAPEUTICS, INC., ABBVIE INC.
    Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James P. Petzel, Julie J. Pruyne, Douglas M. Reamer
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20200325506
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: November 4, 2019
    Publication date: October 15, 2020
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Enzymatic processes for the preparation of (±)-2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid and (±)-2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acid
    Patent number: 10689675
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 23, 2020
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • ENZYMATIC PROCESS FOR THE PREPARATION OF (1S,2R)-2-(DIFLUOROMETHYL)-1-(PROPOXYCARBONYL)CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20200024621
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 23, 2020
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Stefan Mix, Gareth J. Brown
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10465216
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: November 5, 2019
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME
    Publication number: 20190290723
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Application
    Filed: June 11, 2019
    Publication date: September 26, 2019
    Applicants: Melinta Therapeutics Inc., AbbVie Inc.
    Inventors: Adel RAFAI FAR, Gopal KRISHNA, Min DING, Sanjay R. CHEMBURKAR, Carl M. KNABLE, James P. PETZEL, Julie J. PRUYNE, Douglas M. REAMER
  • High purity oritavancin and method of producing same
    Patent number: 10328118
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: June 25, 2019
    Assignees: MELINTA THERAPEUTICS, INC., ABBVIE INC.
    Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James P. Petzel, Julie J. Pruyne, Douglas M. Reamer
  • Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid
    Patent number: 10316338
    Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 11, 2019
    Assignee: Abb Vie Inc.
    Inventors: Michael J. Abrahamson, Angelica B. Kielbus, William T. Riordan, David R. Hill, Sanjay R. Chemburkar, Rajarathnam E. Reddy, Timothy B. Towne, Jianzhang Mei, Gareth J. Brown, Stefan Mix
  • VARIANT POLYPEPTIDES CAPABLE OF AMINATING ALIPHATIC ALPHA KETO ACIDS
    Publication number: 20190048326
    Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
    Type: Application
    Filed: October 26, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Abrahamson, Rajarathnam E. Reddy, William T. Riordan, Sanjay R. Chemburkar
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-NON-8-ENOIC ACID
    Publication number: 20190048372
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 14, 2019
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • Variant polypeptides capable of aminating aliphatic alpha keto acids
    Patent number: 10113152
    Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: October 30, 2018
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Rajarathnam E. Reddy, William T. Riordan, Sanjay R. Chemburkar
  • ENZYMATIC PROCESSES FOR THE PREPARATION OF (±)-2-(DIFLUOROMETHYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID AND (±)-2-(VINYL)-1-(ALKOXYCARBONYL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20180258451
    Abstract: Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Application
    Filed: February 1, 2018
    Publication date: September 13, 2018
    Inventors: Michael J. Abrahamson, Sanjay R. Chemburkar, Angelica B. Kielbus, Russell D. Cink
  • Process for the preparation of (S)-2-amino-non-8-enoic acid
    Patent number: 10059969
    Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 28, 2018
    Assignee: AbbVie Inc.
    Inventors: Michael J. Abrahamson, Julie J. Pruyne, Angelica B. Kielbus, John E. Lallaman, Rajarathnam E. Reddy, Sanjay R. Chemburkar
  • HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME
    Publication number: 20170157206
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 8, 2017
    Applicants: The Medicines Company, AbbVie Inc.
    Inventors: Adel RAFAI FAR, Gopal KRISHNA, Min DING, Sanjay R. CHEMBURKAR, Carl M. KNABLE, James P. PETZEL, Julie J. PRUYNE, Douglas M. REAMER
  • High purity oritavancin and method of producing same
    Patent number: 9649352
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: May 16, 2017
    Assignees: THE MEDICINES COMPANY, ABBVIE INC.
    Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James P. Petzel, Julie J. Pruyne, Douglas M. Reamer
  • Polymorph of a pharmaceutical
    Patent number: 9255092
    Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: February 9, 2016
    Assignee: AbbVie Inc.
    Inventors: John F. Bauer, Azita Saleki-Gerhardt, Bikshandarkoil A. Narayanan, Sanjay R. Chemburkar, Ketan M. Patel, Harry O. Spiwek, Philip E. Bauer, Kimberly A. Allen
  • HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME
    Publication number: 20160015772
    Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.
    Type: Application
    Filed: July 16, 2015
    Publication date: January 21, 2016
    Applicant: The Medicines Company
    Inventors: Adel Rafai Far, Gopal Krishna, Min Ding, Sanjay R. Chemburkar, Carl M. Knable, James J. Petzel, Julie J. Pruyne, Douglas M. Reamer
  • POLYMORPH OF A PHARMACEUTICAL
    Publication number: 20150031731
    Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
    Type: Application
    Filed: October 14, 2013
    Publication date: January 29, 2015
    Applicant: AbbVie Inc.
    Inventors: John F. Bauer, Azita Saleki-Gerhardt, Bikshandarkoil A. Narayanan, Sanjay R. Chemburkar, Ketan M. Patel, Harry O. Spiwek, Philip E. Bauer, Kimberly A. Allen
  • Polymorph of a pharmaceutical
    Patent number: 8674112
    Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: March 18, 2014
    Assignee: AbbVie Inc.
    Inventors: John F. Bauer, Azita Saleki-Gerhardt, Bikshandarkoil A. Narayanan, Sanjay R. Chemburkar, Ketan M. Patel, Harry O. Spiwek, Philip E. Bauer, Kimberly A. Allen