Abstract: A device with integrated methods for carrying out reverse transcription polymerase chain reaction (RT-PCR) and/or array based analysis involving signal generating agents (gold nanoclusters) comprising a heating and cooling cycle based synthesis selectively with DIMA and protein as templates. The advancement is further directed to a portable device adapted for RT-PCR and array based gene and protein expression analyses based on a common detection agent involving luminescence of in-situ synthesized gold nanoclusters with adaptability for user friendly graphical user interface (GUI) for controlling, visualization and analysis of the data.

Abstract: In some examples, artificial intelligence and machine learning based incident management may include analyzing incident data related to a plurality of incidents associated with organization operations of an organization to train and test a machine learning classification model. Based on mapping of the organization operations to associated organizational key performance indicators, a corpus may be generated and used to determine an organizational key performance indicator that is impacted by each incident. New incident data related to a further plurality of incidents may be ascertained, and specified organizational key performance indicators associated with further organizational operations may be determined.

Abstract: Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a PD-1 inhibitor. A pharmaceutical combination comprising a therapeutically effective amount of a c-Rel inhibitor, and a therapeutically effective amount of a PD-1 inhibitor is also provided. Finally, methods of treating a cancer such as a CTLA-4-resistant cancer, a CD137-resistant cancer, and an OX-4-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a CLTA-4, CD137 or OX-4 inhibitor, respectively.

Abstract: Embodiments of the present disclosure provide systems and methods for recognizing a masked face. According to the present disclosure, the disclosed systems and methods include features that provide augmentation of existing face recognition databases, real-time mask detection, and real-time masked face recognition. In embodiments, masked face recognition includes a multi-layered approach, which includes finding matching simulated masked faces in the database that match the masked face being analyzed, comparing the unmasked portion of the masked face to stored unmasked faces in a database to identify any matches, and executing face restoration algorithms in which the masked portion is reconstructed to generate an unmasked representation which may then be matched against unmasked faces in the database.

Abstract: Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a PD-1 inhibitor. A pharmaceutical combination comprising a therapeutically effective amount of a c-Rel inhibitor, and a therapeutically effective amount of a PD-1 inhibitor is also provided. Finally, methods of treating a cancer such as a CTLA-4-resistant cancer, a CD137-resistant cancer, and an OX-4-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a CLTA-4, CD137 or OX-4 inhibitor, respectively.

Abstract: In some examples, artificial intelligence and machine learning based incident management may include analyzing incident data related to a plurality of incidents associated with organization operations of an organization to train and test a machine learning classification model. Based on mapping of the organization operations to associated organizational key performance indicators, a corpus may be generated and used to determine an organizational key performance indicator that is impacted by each incident. New incident data related to a further plurality of incidents may be ascertained, and specified organizational key performance indicators associated with further organizational operations may be determined.

Abstract: A device with integrated methods for carrying out reverse transcription polymerase chain reaction (RT-PCR) and/or array based analysis involving signal generating agents (gold nanoclusters) comprising a heating and cooling cycle based synthesis selectively with DIMA and protein as templates. The advancement is further directed to a portable device adapted for RT-PCR and array based gene and protein expression analyses based on a common detection agent involving luminescence of in-situ synthesized gold nanoclusters with adaptability for user friendly graphical user interface (GUI) for controlling, visualization and analysis of the data.

Abstract: Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a PD-1 inhibitor. A pharmaceutical combination comprising a therapeutically effective amount of a c-Rel inhibitor, and a therapeutically effective amount of a PD-1 inhibitor is also provided. Finally, methods of treating a cancer such as a CTLA-4-resistant cancer, a CD137-resistant cancer, and an OX-4-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a CLTA-4, CD137 or OX-4 inhibitor, respectively.

Abstract: The present invention relates to a method of inhibiting onset of or preventing development of a psoriatic lesion in a patient having psoriasis. The method comprises administering to a patient having psoriasis an effective amount of an agent that inhibits NF-?B activity under conditions effective to inhibit onset of or prevent development of psoriatic lesions. Another aspect of the invention relates to a method of treating an early stage psoriatic lesion on a patient by contacting the early stage psoriatic lesion of a patient with an effective amount of an agent that inhibits NF-?B activity, whereby said contacting inhibits development of the early stage psoriatic lesion. Both transgenic and nontransgenic approaches are contemplated.

Abstract: A portable magnifying instrument useful for colposcopy is provided which may include in combination an optical system capable of providing a distortion free clear continuously varying 10× to 15× magnification of a three-dimensional wide object; an integrated energy efficient, low powered and intensity controlled illumination system; a power pack and mounting. The optical system may have an eyepiece lens system and an objective lens system. The illumination system may have a plurality of light emitting diodes (LEDs) connected to the power pack; mounted in such a manner that the angle between the LEDs is maintained with respect to the optical axis of the lens system and that the light beam from the said LEDs impinges on the wide object to be observed at the focus of the said lens system.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: An automated tunnel-type scanning system arranged about a conveyor belt structure, including: a tunnel structure arranged about a conveyor belt structure for transporting packages; an omni-directional bar code symbol scanning subsystem; a package detection and dimensioning subsystem; and a data management subsystem. The package detection and dimensioning subsystem captures package measurement information about each detected package prior to the package being scanned by the omni-directional bar code symbol reading subsystem, and producing package measurement data representative of the captured package measurement information.

Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: A hand-supportable planar laser illumination and imaging (PLIIM) based code symbol reader includes: a hand-supportable housing having light transmission aperture; a linear image formation and detection module having a linear image detection array; and a planar laser illumination beam (PLIB) producing device having at least one visible laser diode (VLD) for producing a planar light illumination beam (PLIB). The code symbol reader further includes image grabber for grabbing digital linear images formed and detected by the image formation and detection module, an image data buffer for buffering the digital linear images grabbed by the image grabber and constructing a two-dimensional image from a series of buffered linear digital images, and an image processing computer for processing the buffered two-dimensional digital image so as to read code symbols graphically represented in the two-dimensional digital linear image.