Patents by Inventor Santhosh Neelamkavil

Santhosh Neelamkavil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPIDATED PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR
    Publication number: 20240173309
    Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.
    Type: Application
    Filed: October 26, 2023
    Publication date: May 30, 2024
    Inventors: Santhosh NEELAMKAVIL, Chengzao SUN, Sandeep SOMANI, Stephanie A. BARROS, Raymond J. PATCH, Jing ZHANG, Douglas RIEXINGER, Charles HENDRICK, Elisabetta BIANCHI, Roberto COSTANTE, Federica ROSOLIA, Martina LOLLOBRIGIDA, Sonia DEL RIZZO, Danila BRANCA, Ashok BHANDARI, James DANIEL, Tran Trung TRAN, Brian FREDERICK
  • Factor XIa inhibitors
    Patent number: 10239863
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 26, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Ning Shao, Scott D. Edmondson, Santhosh Neelamkavil, Zhuyan Guo, Eric Mertz, Yi Zang, Jiafang He
  • Factor XIa Inhibitors
    Publication number: 20180179180
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Application
    Filed: October 20, 2017
    Publication date: June 28, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Ning Shao, Scott D. Edmondson, Santhosh Neelamkavil, Zhuyan Guo, Eric Mertz, Yi Zang, Jiafang He
  • Factor XIa inhibitors
    Patent number: 9809545
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: November 7, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Anthony Ogawa, Scott Edmondson, Mark Erion, Santhosh Neelamkavil, Zhuyan Guo, Rudrajit Mal, Jiafang He, Weiguo Liu, Ellen K. Vande Bunte
  • Factor XIa Inhibitors
    Publication number: 20160257668
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Application
    Filed: October 6, 2014
    Publication date: September 8, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Ning SHAO, Scott D. EDMONDSON, Santhosh NEELAMKAVIL, Zhuyan GUO, Eric MERTZ, Yi ZANG, Jiafang HE
  • Factor XIa Inhibitors
    Publication number: 20160229839
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 11, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Eric Mertz, Scott D. Edmondson, Ning Shao, Santhosh Neelamkavil, Corey Poker, Zahid Hussain, Zhuyan Guo, Nancy Jo Kevin, Yi Zang, Jiafang He
  • Factor XIa Inhibitors
    Publication number: 20160046581
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
    Type: Application
    Filed: March 21, 2014
    Publication date: February 18, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Anthony Ogawa, Scott Edmondson, Mark Erion, Santhosh Neelamkavil, Zhuyan Guo, Rudrajit Mal, Jiafang He, Weiguo Liu, Ellen K. Vande Bunte
  • Morpholinone compounds as factor IXA inhibitors
    Patent number: 8987242
    Abstract: The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 24, 2015
    Assignees: Merck Sharp & Dohme Corp., Mochida Pharmaceuticals Co., Ltd.
    Inventors: Samuel Chackalamannil, Tin-Yau Chan, Mariappan V. Chelliah, Martin C. Clasby, Michael Dwyer, William J. Greenlee, Tomokazu Hirabayashi, Santhosh Neelamkavil, Hidemitsu Nishida, Fumihiko Saitoh, Unmesh Shah, Yan Xia
  • HCV NS3 protease inhibitors
    Patent number: 8987195
    Abstract: The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: March 24, 2015
    Assignees: Merck Sharp & Dohme Corp., Merck Canada Inc.
    Inventors: Thomas Bara, Sathesh Bhat, Dipshikha Biswas, Linda Brockunier, Duane A. Burnett, Samuel Chackalamannil, Mariappan V. Chelliah, Austin Chen, Martin Clasby, Vince J. Colandrea, Zhuyan Guo, Yongxin Han, Charles Jayne, Hubert Josien, Karen Marcantonio, Shouwu Miao, Santhosh Neelamkavil, Patrick Pinto, Murali Rajagopalan, Unmesh Shah, Francisco Velazquez, Srikanth Venkatraman, Yan Xia
  • HCV NS3 PROTEASE INHIBITORS
    Publication number: 20140057836
    Abstract: The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.
    Type: Application
    Filed: August 6, 2013
    Publication date: February 27, 2014
    Inventors: Thomas BARA, Sathesh Bhat, Dipshika Biswas, Linda Brockunier, Duane Burnette, Samuel Chackalamannil, Mariappan Vasu Cheliah, Austin Chen, Martin Clasby, Vince J. Colandrea, Zhuyan Guo, Yongxin Han, Charles Jayne, Hubert Josien, Karen Marcantonio, Shouwu Miao, Santhosh Neelamkavil, Patrick Pinto, Murali Rajogopalan, Unmesh Shah, Francisco Velazquez, Srikanth Venkatraman, Yan Xia
  • MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS
    Publication number: 20110135650
    Abstract: The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
    Type: Application
    Filed: June 1, 2010
    Publication date: June 9, 2011
    Inventors: Samuel CHACKALAMANNIL, Tin-Yau CHAN, Mariappan V. CHELLIAH, Martin C. CLASBY, Michael DWYER, William J. GREENLEE, Tomokazu HIRABAYASHI, Santhosh NEELAMKAVIL, Hidemitsu NISHIDA, Fumihiko SAITOH, Unmesh SHAH, Yan XIA
  • SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
    Publication number: 20110129542
    Abstract: In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11?-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11?-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: August 12, 2008
    Publication date: June 2, 2011
    Inventors: Santhosh Neelamkavil, Craig D. Boyle, Samuel Chackalamannil
  • Method of hydroborating alcohols and reducing functional groups using a recyclable fluorous borane-sulfide
    Patent number: 6849767
    Abstract: A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: February 1, 2005
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: David C. Crich, Santhosh Neelamkavil
  • Method of hydroborating alcohols and reducing functional groups using a recyclable fluorous borane-sulfide
    Publication number: 20040116747
    Abstract: A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.
    Type: Application
    Filed: July 24, 2003
    Publication date: June 17, 2004
    Inventors: David C. Crich, Santhosh Neelamkavil
  • Method of oxidizing an alcohol using a recyclable fluorous sulfoxide
    Patent number: 6620972
    Abstract: A method of oxidizing primary and secondary alcohols to an aldehyde or ketone using a fluorous sulfoxide or a fluorous sulfide is disclosed. The method includes regenerating and recycling the fluorous sulfoxide.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: September 16, 2003
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: David Crich, Santhosh Neelamkavil
  • Method of oxidizing an alcohol using a recyclable fluorous sulfoxide
    Publication number: 20030105363
    Abstract: A method of oxidizing primary and secondary alcohols to an aldehyde or ketone using a fluorous sulfoxide or a fluorous sulfide is disclosed. The method includes regenerating and recycling the fluorous sulfoxide.
    Type: Application
    Filed: June 18, 2002
    Publication date: June 5, 2003
    Inventors: David Crich, Santhosh Neelamkavil