Patents by Inventor Santiago Gubert

Santiago Gubert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing (-)-trans-N-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-[[3,4-(methylened ioxy)phenoxy]methyl]-piperidine
    Patent number: 5973155
    Abstract: The process consists of reacting (-)trans-N-p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperid ine acetate with 2-chloro- or 2-bromo-4'-fluoroacetophenone. The resulting compound can be isolated as a pharmaceutically acceptable addition salt by reaction with the corresponding acid.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: October 26, 1999
    Assignee: Ferrer Internacional, S.A.
    Inventors: Rafael Foguet, Santiago Gubert, Aurelio Sacristan, Jose A. Ortiz
  • N-benzoylmethyl-piperidines
    Patent number: 5665736
    Abstract: The invention relates to new N-benzoylmethyl-piperidines of the general formula (I): ##STR1## wherein X is a halogen atom, as well as their pharmaceutically acceptable addition salts. The compounds are potentially useful to treat depressions.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: September 9, 1997
    Assignee: Ferrer Internacional, S.A.
    Inventors: Rafael Foguet, Santiago Gubert, Aurelio Sacristan, Jose A. Ortiz
  • N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds
    Patent number: 5561135
    Abstract: The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p--F--C.sub.6 H.sub.4 --CH) group and R is a benzyl group optionally substituted in p-- with an halogen, or R is a 2-pyrimidinyl group with the proviso that simultaneously X may not be p-fluorophenyl-methylen (p--F--C.sub.6 H.sub.4 --CH) and R may not be an unsubstituted benzyl group, as well as their pharmaceutically acceptable additions salts.The compounds are potentially useful in the treatment of sigma receptor-related nervous system diseases.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: October 1, 1996
    Assignee: Ferrer Internacional, S.A.
    Inventors: Rafael Foguet, Santiago Gubert, Jos e Ortiz, Aurelio Sacrist an, Josep M. Castell o
  • Derivatives of piperazine, method for making the same
    Patent number: 4883797
    Abstract: Derivatives of piperazine having the general formula ##STR1## wherein R.sub.1 is benzhydryl or cinnamyl and R.sub.2 is selected from the group consisting of ##STR2## --(CH.sub.2).sub.3 --R.sub.8, --CH.sub.2 NHR.sub.9, --CH.sub.2 NH.sub.2 and --COR.sub.10 ; wherein R.sub.3 is hydrogen, chloromethyl, (4-benzhydryl-1-piperazinyl) methyl, 4-morpholinylmethyl or 1-piperidinylmethyl, R.sub.4 is hydrogen, chloromethyl or carbethoxy, R.sub.5 and R.sub.6 taken together are an oxygen atom or the radical --O--(CH.sub.2).sub.2 --O--, R.sub.7 is methyl, phenyl or 2-thienyl, R.sub.8 is 4-morpholinyl, 1-piperidinyl or 4-benzhydryl-1-piperazinyl, R.sub.9 is 2-oxo-1- (pyrrolidinyl) acetyl, 2-hydroxybenzoyl or 4-sulfamoylbenzoyl, R.sub.10 is 2-oxo-1-(pyrrolidinyl)methyl or 4-sulfamoylphenyl and X is oxygen or NH; as well as methods for making the same and their use in a pharmaceutical composition is proposed. The compounds have cardiovascular properties and increasing effects on cerebral flow.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: November 28, 1989
    Assignee: Ferrer Internacional, S.A.
    Inventors: Rafael Foguet, Jose A. Ortiz, Santiago Gubert, Manuel M. Raga, Aurelio Sacristan
  • Piperazine derivative and pharmaceutical composition containing the same
    Patent number: 4603134
    Abstract: A piperazine derivative is disclosed of formula (I): ##STR1## and the non-toxic addition salts thereof, along with a process for preparation, pharmaceutical composition, and method of treating conditions characterized by histamine activity.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: July 29, 1986
    Assignee: Ferrer International, S.A.
    Inventors: Rafael Foguet, Santiago Gubert, Manuel Raga, Aurelio Sacristan, Jose A. Ortiz