Abstract: The present invention relates to soluble epoxide hydrolase (sEH) inhibitors of formula (I) to processes for their obtention and to their therapeutic indications.

Abstract: The present invention relates to soluble epoxide hydrolase (sEH) inhibitors of formula (I) to processes for their obtention and to their therapeutic indications.

Abstract: N-(2-oxaadamantan-1-yl)ureas of formula I, where R3 is H, C1-C3 alkyl, cyclohexyl or phenyl; R is —[CH2]n—Y; n is 0-15; in —[CH2]n— 0-n/3 of the methylene groups are optionally replaced by non adjacent oxygen atoms; and Y is a 3- or 4-substituted phenyl, a 3- or 4-substituted cyclohexyl, a N-substituted piperidin-4-yl, a N-substituted piperidin-3-yl, a di- or tri-fluorosubstituted phenyl, 4-chloro-3-trifluoromethylphenyl, 3-chloro-4-trifluoromethylphenyl, 4-fluoro-3-trifluoromethylphenyl, or 3-fluoro-4-trifluoromethylphenyl; have epoxide hydrolase (sEH) inhibitory activities similar to those of their N-(adamantan-1-yl)urea analogs. Thus, compounds I are useful as API for the treatment of sEH mediated diseases. Besides, in general, compounds I have higher water solubilities and lower melting points, what make them more promising from the point of view of pharmacokinetics and formulation.

Abstract: Compounds of formula (I) include: X is CH or N, preferably CH; n is 1-5, preferably 1-2; m is 0-5, preferably 1-2; and, when m is 2-5, two of the R2 radicals taken together with two adjacent carbons of the benzene ring can form a 5- or 6-membered heterocyclic ring fused with the benzene ring. Compounds of formula (I) are heme-regulated inhibitor (HRI) activators and useful for prevention or treatment of cardiometabolic diseases such as metabolic syndrome, obesity, insulin resistance, type 2 diabetes mellitus, non-alcoholic fatty liver disease, steatosis, non-alcoholic steatohepatitis, hypertension, dyslipidemia, atherosclerosis, and heart disease.

Abstract: A method is provided in one example embodiment and includes receiving a request to create a path through a network, wherein the path originates on a first network device and terminates on the second network device; identifying a first controller associated with the first network device, wherein the first controller proxies control plane functions for the first network device; identifying a second controller associated with the second network device, wherein the second controller proxies control plane functions for the second network device; and computing the path using the first controller as a source and the second controller as a destination. The first controller installs the computed path on the first network device and the second controller installs the computed path on the second network device.

Abstract: A method is provided in one example embodiment and includes receiving a request to create a path through a network, wherein the path originates on a first network device and terminates on the second network device; identifying a first controller associated with the first network device, wherein the first controller proxies control plane functions for the first network device; identifying a second controller associated with the second network device, wherein the second controller proxies control plane functions for the second network device; and computing the path using the first controller as a source and the second controller as a destination. The first controller installs the computed path on the first network device and the second controller installs the computed path on the second network device.

Abstract: A method is provided in one example embodiment and includes configuring a local network element as an autonomic registrar for a designated network domain; establishing an autonomic control plane (“ACP”) between the local network element and one or more remote network elements identified by local network element as a remote neighbor; designating a locally-defined subnet at the local network element to be extended to each of the one or more remote network elements; and executing an ACP command at the local network element, wherein the executing triggers a message to each of the one or more remote network elements, the message including information regarding the designated local subnet. The information included in the message is used by each of the remote network elements to auto-resolve its Locator/Identifier Separation Protocol (“LISP”) configuration, enabling the designated local subnet to be extended to each of the one or more remote network elements.

Abstract: A method is provided in one example embodiment and includes receiving a request to create a path through a network, wherein the path originates on a first network device and terminates on the second network device; identifying a first controller associated with the first network device, wherein the first controller proxies control plane functions for the first network device; identifying a second controller associated with the second network device, wherein the second controller proxies control plane functions for the second network device; and computing the path using the first controller as a source and the second controller as a destination. The first controller installs the computed path on the first network device and the second controller installs the computed path on the second network device.

Abstract: A method is provided in one example embodiment and includes receiving a request to create a path through a network, wherein the path originates on a first network device and terminates on the second network device; identifying a first controller associated with the first network device, wherein the first controller proxies control plane functions for the first network device; identifying a second controller associated with the second network device, wherein the second controller proxies control plane functions for the second network device; and computing the path using the first controller as a source and the second controller as a destination. The first controller installs the computed path on the first network device and the second controller installs the computed path on the second network device.

Abstract: The present disclosure describes methods and systems for enabling a migration of network elements from a first location to a second location remote from the first location without changing the Internet Protocol (IP) addresses, subnet mask, and/or default gateway of the network elements. The first location has a first Locator/Identifier Separation Protocol (LISP) router configured on a stick and the second location having a second LISP router configured on a stick. Both the first LISP router and the second LISP router are on the same subnet. Effectively, LISP provides a Layer 3 extension stretching a subnet across the first location and the second location (Stretched Subnet Mode (SSM)). By implementing LISP routers in this manner, system engineers can migrate network elements easily between two locations.

Abstract: The present disclosure describes methods and systems for enabling a migration of network elements from a first location to a second location remote from the first location without changing the Internet Protocol (IP) addresses, subnet mask, and/or default gateway of the network elements. The first location has a first Locator/Identifier Separation Protocol (LISP) router configured on a stick and the second location having a second LISP router configured on a stick. Both the first LISP router and the second LISP router are on the same subnet. Effectively, LISP provides a Layer 3 extension stretching a subnet across the first location and the second location (Stretched Subnet Mode (SSM)). By implementing LISP routers in this manner, system engineers can migrate network elements easily between two locations.

Abstract: A method is provided in one example embodiment and includes configuring a local network element as an autonomic registrar for a designated network domain; establishing an autonomic control plane (“ACP”) between the local network element and one or more remote network elements identified by local network element as a remote neighbor; designating a locally-defined subnet at the local network element to be extended to each of the one or more remote network elements; and executing an ACP command at the local network element, wherein the executing triggers a message to each of the one or more remote network elements, the message including information regarding the designated local subnet. The information included in the message is used by each of the remote network elements to auto-resolve its Locator/Identifier Separation Protocol (“LISP”) configuration, enabling the designated local subnet to be extended to each of the one or more remote network elements.

Abstract: The present disclosure describes methods and systems for enabling a migration of network elements from a first location to a second location remote from the first location without changing the Internet Protocol (IP) addresses, subnet mask, and/or default gateway of the network elements. The first location has a first Locator/Identifier Separation Protocol (LISP) router configured on a stick and the second location having a second LISP router configured on a stick. Both the first LISP router and the second LISP router are on the same subnet. Effectively, LISP provides a Layer 3 extension stretching a subnet across the first location and the second location (Stretched Subnet Mode (SSM)). By implementing LISP routers in this manner, system engineers can migrate network elements easily between two locations.

Abstract: The compounds of formula (I), or its pharmaceutically acceptable salts, or any stereoisomer or mixture thereof, wherein: R1 is a (C1-C2) alkyl radical; R2 and R3 are radicals independently selected from the group consisting of F, CI and methyl R4 is H or OH; A is a birradical selected from the group consisting of —(CH2)n— and —(CH2)-phenyl-(CH2)—; t is an integer from 0 to 1; and n is an integer from 8 to 15, are useful for the treatment of Alzheimer's disease.

Abstract: The compounds of formula (I), or its pharmaceutically acceptable salts, or any stereoisomer or mixture thereof, wherein: R1 is a (C1-C2) alkyl radical; R2 and R3 are radicals independently selected from the group consisting of F, Cl and methyl R4 is H or OH; A is a birradical selected from the group consisting of —(CH2)n— and —(CH2)-phenyl-(CH2)—; t is an integer from 0 to 1; and n is an integer from 8 to 15, are useful for the treatment of Alzheimer's disease.

Abstract: Clonal strains of bacteria derived from Pseudopterogorgia elisabethae are capable of making pseudopterosins in in vitro cultures without requiring the presence of other bacteria, algae, or animal cells that are normally present in P. elisabethae.

Abstract: Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.

Abstract: Featured are devices, methods and kits for preparation of samples of peptides and proteins from a solution; more particularly to such devices and methods in which carbon nanotubes are utilized for sample preparation and/or purification of peptide and/or protein samples from a solution. A sample to be treated/processed can comprise proteins, peptides or any other molecule having an amine moiety that can be protonated under low pH, such as, but not limited to, pH 5. Such a sample also can contain contaminants such as salts, detergents, etc. that will be eliminated during the sample preparation/purification process of the present invention. The methods, devices and kits of the present invention advantageously provide for the concentration of the sample, removal of contaminants and ease of manipulation of small liquids without the concomitant loss of sample.

Abstract: Clonal strains of bacteria derived from Pseudopterogorgia elisabethae are capable of making pseudopterosins in in vitro cultures without requiring the presence of other bacteria, algae, or animal cells that are normally present in P. elisabethae.

Abstract: Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.