Patents by Inventor Santimukul Santra
Santimukul Santra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11307199Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.Type: GrantFiled: March 19, 2019Date of Patent: April 19, 2022Assignee: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath
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Publication number: 20210388160Abstract: A polyethylene glycol-functionalized triglyceride polyol polymer comprising a glycerol component and three fatty acid components bonded to the glycerol component, wherein at least one of the fatty acid components comprises: a fatty acid chain; a hydroxyl functional group bound to a carbon atom of the fatty acid chain; and a polyethylene glycol-based functional group bound to an adjacent carbon atom of the fatty acid chain; according to Structure I wherein: n is from 10 to 40; and R is selected from the group consisting of H, alkyl, and silyl.Type: ApplicationFiled: April 23, 2021Publication date: December 16, 2021Inventor: Santimukul Santra
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Publication number: 20210371389Abstract: A method of producing a triazoline-containing compound, the method comprising reacting an alkene, which comprises at least one a C?C double bond, with an azido compound, which comprises an azide anion having the chemical formula N3?, wherein the alkene and the azido compound are constituents of a reaction mixture, so that a C—C single bond forms between the carbon atoms of the at least one C?C double bond and each of carbon atom of the C—C single bond also has a single bond with a different nitrogen atom of the azide anion thereby producing the triazoline-containing compound.Type: ApplicationFiled: April 23, 2021Publication date: December 2, 2021Inventor: Santimukul Santra
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Publication number: 20210236665Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Inventors: Jesus Manuel PEREZ, Santimukul SANTRA
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Publication number: 20210228733Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.Type: ApplicationFiled: April 12, 2021Publication date: July 29, 2021Applicants: University of Central Florida Research Foundation, Inc., Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Memorial Sloan Kettering Cancer CenterInventors: Annette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
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Patent number: 10980902Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.Type: GrantFiled: July 14, 2017Date of Patent: April 20, 2021Assignee: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Santimukul Santra
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Patent number: 10973925Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.Type: GrantFiled: April 28, 2016Date of Patent: April 13, 2021Assignees: University of Central Florida Research Foundation Inc., Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Memorial Sloan Kettering Cancer CenterInventors: Annette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
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Publication number: 20200023086Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanopartides can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapueitc compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.Type: ApplicationFiled: July 14, 2017Publication date: January 23, 2020Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Jesus Manuel PEREZ, Santimukul SANTRA
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Publication number: 20190277841Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.Type: ApplicationFiled: March 19, 2019Publication date: September 12, 2019Inventors: Jesus Manuel PEREZ, Atul ASATI, Santimukul SANTRA, Charalambos KAITTANIS, Sudip NATH
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Publication number: 20190255101Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.Type: ApplicationFiled: February 25, 2019Publication date: August 22, 2019Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis
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Patent number: 10261074Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.Type: GrantFiled: November 10, 2014Date of Patent: April 16, 2019Assignee: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath
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Patent number: 10213458Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.Type: GrantFiled: September 23, 2015Date of Patent: February 26, 2019Assignee: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis
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Publication number: 20180126002Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.Type: ApplicationFiled: April 28, 2016Publication date: May 10, 2018Inventors: Annette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
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Patent number: 9555008Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.Type: GrantFiled: February 22, 2016Date of Patent: January 31, 2017Assignee: University of Central Florida Research Foundation, Inc.Inventors: J. Manuel Perez, Santimukul Santra
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Publication number: 20160256402Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.Type: ApplicationFiled: February 22, 2016Publication date: September 8, 2016Inventors: J. Manuel Perez, Santimukul Santra
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Publication number: 20160074434Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.Type: ApplicationFiled: September 23, 2015Publication date: March 17, 2016Applicant: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis
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Publication number: 20160074334Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.Type: ApplicationFiled: September 23, 2015Publication date: March 17, 2016Applicant: University of Central Florida Research Foundation, Inc.Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis
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Patent number: 9267002Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.Type: GrantFiled: June 19, 2015Date of Patent: February 23, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: J. Manuel Perez, Santimukul Santra
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Publication number: 20150284507Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.Type: ApplicationFiled: June 19, 2015Publication date: October 8, 2015Inventors: J. Manuel Perez, Santimukul Santra
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Patent number: 8883519Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.Type: GrantFiled: February 12, 2010Date of Patent: November 11, 2014Assignee: University of Central Florida Research Foundation, Inc.Inventors: J. Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath