Patents by Inventor Sara Chesworth Keene

Sara Chesworth Keene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 7803931
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: September 28, 2010
    Assignee: Archemix Corp.
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Chesworth Keene, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna J. Zoltoski
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Patent number: 7579450
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: August 25, 2009
    Assignee: Archemix Corp.
    Inventors: Paula Burmeister, Sharon Cload, John L. Diener, Anthony Dominic Keefe, Sara Chesworth Keene, Markus Kurz, H. A. Daniel Lagassé, Harold Nicholas Marsh, Pooja Sawhney, Chunhua Wang
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 7538211
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: May 26, 2009
    Assignee: Archemix Corp.
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Chesworth Keene, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna J. Zoltoski
  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20090082555
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: June 9, 2008
    Publication date: March 26, 2009
    Inventors: John L. Diener, Alicia Ferguson, Nobuko Hamaguchi, Sara Chesworth Keene, H.A. Daniel Lagasse, Pooja Sawhney, Kristin Thompson
  • Method for in vitro selection of 2'-substituted nucleic acids
    Publication number: 20040197804
    Abstract: Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.
    Type: Application
    Filed: December 3, 2003
    Publication date: October 7, 2004
    Inventors: Anthony D. Keefe, Charles Wilson, Paula Burmeister, Sara Chesworth Keene