Abstract: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.

Abstract: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.

Abstract: This invention relates to an apparatus and a method for optically stimulating and detecting the electrical activity of at least one cell (2A, . . . , 2D) in a cell culture (2) placed on a substrate (3). The apparatus (1) is capable of exciting a bio-activatable molecule (16) positioned in the vicinity of at least one cell (2A, . . . , 2D) through the introduction of a light stimulus in at least one transmission means (5, 5A, . . . , 5D), the latter being located in relation to said at least one cell (2A, . . . , 2D) in such a way that the light stimulus is propagated within said transmission means (5, 5A, . . . , 5D). The apparatus according to the invention has the feature of detecting a light component which is radiated by a fluorescent marker due to the generation of said electrical activity of said at least one cell (2A, . . . , 2D), said light component being propagated through said at least one transmission means (5, 5A, . . . , 5D).

Abstract: A bone prosthesis has a portion of interface with the bone which comprises a porous layer (2) with cavities (3, 4) having prefixed and reproducible dimensions and arrangement, and at least one osteoinductive layer containing one or more chemical compounds that can stimulate and promote the growth of bone tissue.