Abstract: Oligonucleotide comprising at least one internucleotide phosphorus atom protected with a group of formula —XaSiR3R4R5 provided. Xa represent 0 or S, and R3, R4 and R5 each independently are optionally substituted hydrocarbyl groups, selected such that that total number of carbon atoms in R3 plus R4 plus R5 is 4 or more. Process for the preparation of these oligonucleotides, intermediate compounds useful therein, and process for the preparation of the intermediate compounds are also provided.

Abstract: An infants pacifier and medicine administering unit having a generally shield-shaped body having first and second sides and having an aperture extending therethrough around a generally transverse axis. The aperture is defined by a wall of the body. A flexible nipple having an inlet end and sucking orifice spaced therefrom, and a fluid dispenser having an outlet end, are mounted on opposite sides of the body with the inlet and the outlet being juxtaposed for fluid communication with each other whereby fluid in the dispenser can be injected under pressure into the nipple.