Patents by Inventor Sarah Cheal

Sarah Cheal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-GPA33 MULTI-SPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20240026037
    Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., multi-specific antibodies or antigen binding fragments thereof) that can bind to the GPA33 protein. The multi-specific antibodies of the present technology are useful in methods for detecting and treating a GPA33-associated cancer in a subject in need thereof.
    Type: Application
    Filed: November 17, 2021
    Publication date: January 25, 2024
    Inventors: Brian H. SANTICH, Mao WANG, Nai-Kong V. CHEUNG, Steven LARSON, Sarah CHEAL, Darren VEACH, Mahiuddin AHMED, Hong XU
  • Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof
    Patent number: 11858993
    Abstract: Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 2, 2024
    Assignees: Memorial Sloan Kettering Cancer Center, Massachusetts Institute of Technology
    Inventors: Sarah Cheal, Hong Xu, Steven Larson, Nai-Kong Cheung, Karl Dane Wittrup, Alice Tzeng
  • SYSTEMS FOR IN VIVO MONITORING OF IMMUNE CELLS IN PATIENTS UNDERGOING CELLULAR IMMUNOTHERAPY
    Publication number: 20230346988
    Abstract: The present disclosure provides kits and methods for tracking or monitoring in vivo biodistribution, viability, and/or expansion of immune cells in a cancer patient undergoing cellular immunotherapy.
    Type: Application
    Filed: June 28, 2021
    Publication date: November 2, 2023
    Inventors: Steven Larson, Darren Veach, Sarah Cheal, Ouathek Ouerfelli, Guangbin Yang, Nai-Kong Cheung, Brian Santich, Simone Krebs, Megan Dacek, David Scheinberg
  • C825 EXPRESSING IMMUNE CELLS AND DIAGNOSTIC USES THEREOF
    Publication number: 20230348853
    Abstract: Provided herein are compositions comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and an anti-DOTA C825 antigen binding fragment. The engineered immune cells of the present technology are configured to bind to DOTA haptens that may be complexed with a diagnostic radiopharmaceutical (e.g., 111In). Also disclosed herein are methods for determining the in vivo biodistribution, viability, and expansion of the engineered immune cells described herein.
    Type: Application
    Filed: June 28, 2021
    Publication date: November 2, 2023
    Inventors: Steven Larson, Darren Veach, Sarah Cheal, Ouathek Ouerfelli, Guangbin Yang, Simone Krebs, Megan Dacek, David Scheinberg, Nai-Kong Cheung, Brian Santich
  • DOTA-HAPTEN COMPOSITIONS FOR ANTI-DOTA/ANTI-TUMOR ANTIGEN BISPECIFIC ANTIBODY PRETARGETED RADIOIMMUNOTHERAPY
    Publication number: 20230256121
    Abstract: The present disclosure provides compositions and methods for the detection and treatment of cancer. Specifically, the compositions of the present technology include novel compounds that may be complexed with a radioisotope. Also disclosed herein are methods of the using the DOTA-haptens of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 17, 2023
    Inventors: Steven Larson, Darren Veach, Sarah Cheal, Ouathek Ouerfelli, Guangbin Yang, Nai-Kong Cheung, Brian Santich, Hong Xu
  • MULTIMODAL FLUORINE-CY3/5/7-DOTA-HAPTEN COMPOSITIONS, DIAGNOSTICS, FLUORESCENCE GUIDED SURGERY AND RADIOIMMUNOTHERAPY
    Publication number: 20230095707
    Abstract: The present disclosure provides compositions and methods for the detection, and treatment of cancer. Specifically, the compositions of the present technology include multimodal fluorine-cyanine-DOTA-hapten compositions that may be complexed with a radioisotope (e.g., 175Lu). Also disclosed herein are methods of using the fluorine-cyanine-DOTA-hapten compositions of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy.
    Type: Application
    Filed: December 30, 2020
    Publication date: March 30, 2023
    Inventors: Nai-Kong V. CHEUNG, Steven M. LARSON, Sarah CHEAL, Richard TING, Hari Krishna KOMMIDI, Feifei AN, Brian SANTICH
  • MULTI-SPECIFIC ANTIBODIES WITH AFFINITY FOR HUMAN A33 ANTIGEN AND DOTA METAL COMPLEX AND USES THEREOF
    Publication number: 20210301014
    Abstract: Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
    Type: Application
    Filed: April 13, 2021
    Publication date: September 30, 2021
    Inventors: Sarah CHEAL, Hong XU, Steven LARSON, Nai-Kong CHEUNG, Karl Dane WITTRUP, Alice TZENG
  • Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof
    Patent number: 10988534
    Abstract: Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: April 27, 2021
    Assignees: Memorial Sloan Kettering Cancer Center, Massachusetts Institute of Technology
    Inventors: Sarah Cheal, Hong Xu, Steven Larson, Nai-Kong Cheung, Karl Dane Wittrup, Alice Tzeng
  • BISPECIFIC BINDING AGENTS AND USES THEREOF
    Publication number: 20210017295
    Abstract: Provided herein are compositions, methods, and uses involving (i) bispecific binding agents that specifically bind to a cancer antigen, (ii) clearing agents, and (iii) radiotherapeutic agents for treating cancer. Also provided herein are uses and methods for treating HER2-related cancers.
    Type: Application
    Filed: March 11, 2019
    Publication date: January 21, 2021
    Inventors: Steven LARSON, Nai-Kong V. CHEUNG, Sarah CHEAL
  • MULTI-SPECIFIC ANTIBODIES WITH AFFINITY FOR HUMAN A33 ANTIGEN AND DOTA METAL COMPLEX AND USES THEREOF
    Publication number: 20200140543
    Abstract: Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
    Type: Application
    Filed: February 9, 2016
    Publication date: May 7, 2020
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Sarah CHEAL, Hong XU, Steven LARSON, Nai-Kong CHEUNG, Karl Dane WITTRUP, Alice TZENG
  • Element-coded affinity tags
    Publication number: 20050042695
    Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
    Type: Application
    Filed: May 24, 2004
    Publication date: February 24, 2005
    Applicant: The Regents of the University of California
    Inventors: Claude Meares, Carlito Lebrilla, Nathaniel Butlin, Sarah Cheal, Todd Corneillie, Susan Lee, Paul Whetstone, Nicolas Young