Patents by Inventor Sarah Mueller-Steiner

Sarah Mueller-Steiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of increasing cathepsin B-induced cleavage of amyloid-? peptides
    Patent number: 8388953
    Abstract: The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-? (A?) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 5, 2013
    Assignee: The J. David Gladstone Institutes
    Inventors: Li Gan, Lennart Mucke, Erik Roberson, Sarah Mueller-Steiner
  • Methods and Compositions for Reducing Amyloid Beta Levels
    Publication number: 20110256120
    Abstract: The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-? (A?) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
    Type: Application
    Filed: June 29, 2010
    Publication date: October 20, 2011
    Inventors: Li Gan, Lennart Mucke, Erik Roberson, Sarah Mueller-Steiner
  • Methods and compositions for reducing amyloid beta levels
    Patent number: 7951367
    Abstract: The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-? (A?) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 31, 2011
    Assignee: The J. David Gladstone Institutes
    Inventors: Li Gan, Lennart Mucke, Erik Roberson, Sarah Mueller-Steiner
  • Methods and compositions for reducing amyloid beta levels
    Publication number: 20080160008
    Abstract: The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-? (A?) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
    Type: Application
    Filed: November 15, 2007
    Publication date: July 3, 2008
    Inventors: Li Gan, Lennart Mucke, Erik Roberson, Sarah Mueller-Steiner