Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: In a user device, a determination may be made as to whether an audio output device has been connected to an audio port of the user device. When it is determined that the connection has been made, instructions may be sent to a server, instructing the server to identify only audio content. The audio content identified by the server may be identified by the server in a manner consistent with preferences of the user. The server may send one or more identifiers of the audio content to a user interface of the user device. A selection of a particular audio content item in the audio content may be received at the user device. The corresponding audio content may be received from the server. The audio content may be output via the audio port of the user device. The determining of whether a connection has been made to an audio port, the instructing of the server by the user device, and receiving may be performed by an aggregator application executing on the user device.

Abstract: The present invention provides an image-based encryption and decryption technique where the user uses pre-chosen image categories to create an encryption/decryption key. The encryption key can be used to encrypt alphanumeric strings such as a confirmation code or other information. The user uses the decryption key, i.e., knowledge of the chosen image categories) to decrypt and recover the original message. For example, upon presentation of a grid of images, the user selects certain images contained therein that match the pre-chosen image categories to recover the original message.

Abstract: The present invention provides an image-based encryption and decryption technique where the user uses pre-chosen image categories to create an encryption/decryption key. The encryption key can be used to encrypt alphanumeric strings such as a confirmation code or other information. The user uses the decryption key, i.e., knowledge of the chosen image categories) to decrypt and recover the original message. For example, upon presentation of a grid of images, the user selects certain images contained therein that match the pre-chosen image categories to recover the original message.