Patents by Inventor Sarath P. Gunasekera
Sarath P. Gunasekera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7053118Abstract: The subject invention provides novel compositions of biologically active compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.Type: GrantFiled: March 6, 2003Date of Patent: May 30, 2006Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Ross E. Longley, Amy E. Wright, John K. Reed
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Patent number: 6835736Abstract: The subject invention provides novel compositions of biologically active discorhabdin compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.Type: GrantFiled: February 28, 2003Date of Patent: December 28, 2004Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Ross E. Longley, Shirley A. Pomponi, Amy E. Wright
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Patent number: 6602881Abstract: The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed compounds. Specifically exemplified herein is the use of manzamines A, B, C, D, E, and F, and their salts, analogs, and derivatives.Type: GrantFiled: May 13, 2002Date of Patent: August 5, 2003Assignee: Harbor Branch Oceanograhic Institution, Inc.Inventors: Alejandro Mayer, Sarath P. Gunasekera, Shirley A. Pomponi, Susan H. Sennett
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Patent number: 6495594Abstract: The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.Type: GrantFiled: February 28, 2001Date of Patent: December 17, 2002Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Ross E. Longley, Richard A. Isbrucker, Gopal K. Paul, Shirley A. Pomponi, Amy E. Wright
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Publication number: 20020187999Abstract: The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed compounds. Specifically exemplified herein is the use of manzamines A, B, C, D, E, and F, and their salts, analogs, and derivatives.Type: ApplicationFiled: May 13, 2002Publication date: December 12, 2002Inventors: Alejandro Mayer, Sarath P. Gunasekera, Shirley A. Pomponi, Susan H. Sennett
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Patent number: 6476065Abstract: The subject invention provides novel biologically active compounds which are useful for inhibiting cellular proliferation. Because of the biological activity of these compounds, they can be used for immunomodulation and/or treating cancer. In a preferred embodiment, the novel compounds, compositions and methods of use of the subject invention can advantageously be used to inhibit the growth of tumor cells in a mammalian host. More particularly, the subject compounds can be used for inhibiting in a human the growth of tumor cells, including cells of breast, colon, CNS, ovarian, renal, prostate, bone, gastrointestinal, stomach, testicular, or lung tumors, as well as human leukemia or melanoma cells. Specifically exemplified are discalamides A and B.Type: GrantFiled: April 16, 2001Date of Patent: November 5, 2002Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Ross E. Longley, Gopal K. Paul, Richard A. Isbrucker, Shirley A. Pomponi
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Patent number: 6387916Abstract: The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed compounds. Specifically exemplified herein is the use of manzamines A, B, C, D, E, and F, and their salts, analogs, and derivatives.Type: GrantFiled: March 24, 2000Date of Patent: May 14, 2002Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Alejandro Mayer, Sarath P. Gunasekera, Shirley A. Pomponi, Susan H. Sennett
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Publication number: 20020016357Abstract: The subject invention provides novel biologically active compounds which are useful for inhibiting cellular proliferation. Because of the biological activity of these compounds, they can be used for immunomodulation and/or treating cancer. In a preferred embodiment, the novel compounds, compositions and methods of use of the subject invention can advantageously be used to inhibit the growth of tumor cells in a mammalian host. More particularly, the subject compounds can be used for inhibiting in a human the growth of tumor cells, including cells of breast, colon, CNS, ovarian, renal, prostate, bone, gastrointestinal, stomach, testicular, or lung tumors, as well as human leukemia or melanoma cells. Specifically exemplified are discalamides A and B.Type: ApplicationFiled: April 16, 2001Publication date: February 7, 2002Inventors: Sarath P. Gunasekera, Ross E. Longley, Gopal K. Paul, Richard A. Isbrucker, Shirley A. Pomponi
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Publication number: 20010049387Abstract: The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.Type: ApplicationFiled: February 28, 2001Publication date: December 6, 2001Inventors: Sarath P. Gunasekera, Ross E. Longley, Richard A. Isbrucker, Gopal K. Paul, Shirley A. Pomponi, Amy E. Wright
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Patent number: 6218419Abstract: The subject application concerns novel compounds with useful biological properties. For example, these compounds can be used as antinflammatory, anti-proliferative, immunomodulatory, and/or neuroprotective agents. Specific examples of the compounds of the subject invention include Secobatzelline A and Secobatzelline B, which can be isolated from marine sponges.Type: GrantFiled: July 8, 1999Date of Patent: April 17, 2001Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Peter J. McCarthy, Ross E. Longley, Shirley A. Pomponi, Amy E. Wright
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Patent number: 6127406Abstract: Novel analogs of compounds from the marine sponge Discodermia dissoluta have been prepared. These compounds have been shown to have activity against mammalian cancer cells, and can be used in treating human patients which host cancer cells, including leukemia, melanoma, breast, colon, CNS, renal, ovarian, prostate, and lung tumors.Type: GrantFiled: October 5, 1999Date of Patent: October 3, 2000Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Ross E. Longley
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Patent number: 6090811Abstract: A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, bromotopsentins, homocarbonyltopsentins, nortopsentins, hamacanthins, bis-indole ethylamines, or dragmacidins, pharmaceutical compositions containing the compounds, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.Type: GrantFiled: July 16, 1999Date of Patent: July 18, 2000Assignees: Harbor Branch Oceanographic Institution, Inc., Regents of the Univ. of CaliforniaInventors: Robert S. Jacobs, Shirley A. Pomponi, Sarath P. Gunasekera, Amy E. Wright
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Patent number: 5955462Abstract: A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, bromotopsentins, homocarbonyltopsentins, nortopsentins, hamacanthins, bis-indole ethylamines, or dragmacidins, pharmaceutical compositions containing the compounds, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-neurogenicinflammatory properties exhibited by the bis-indole compounds and their analogs.Type: GrantFiled: October 31, 1997Date of Patent: September 21, 1999Assignees: Harbor Branch Oceanographic Institution, Inc., Regents of the Univ. of CaliforniaInventors: Robert S. Jacobs, Shirley A. Pomponi, Sarath P. Gunasekera, Amy E. Wright
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Patent number: 5840750Abstract: Novel lactone compounds from the marine sponge Discodermia dissoluta have been isolated. These compounds and their analogs have been shown to have activity against mammalian cancer cells, and can be used in treating human patients which host cancer cells, including leukemia, melanoma, and breast, colon, CNS, and lung tumors.Type: GrantFiled: December 5, 1996Date of Patent: November 24, 1998Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Ross E. Longley, Sarath P. Gunasekera, Shirley A. Pomponi
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Patent number: 5681847Abstract: Novel lactone compounds from the marine sponge Discodermia dissoluta have been isolated. These compounds and their analogs have been shown to have activity against mammalian cancer cells, and can be used in treating human patients which host cancer cells, including leukemia, melanoma, and breast, colon, CNS, and lung tumors.Type: GrantFiled: December 5, 1995Date of Patent: October 28, 1997Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Ross E. Longley, Sarath P. Gunasekera
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Patent number: 5516755Abstract: A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial and antitumor agents.Type: GrantFiled: August 8, 1994Date of Patent: May 14, 1996Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Nanda K. Gulavita, Sarath P. Gunasekera, Shirley A. Pomponi, Ross E. Longley, Peter J. McCarthy
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Patent number: 5496950Abstract: A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.Type: GrantFiled: October 28, 1994Date of Patent: March 5, 1996Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Oliver J. McConnell, Gabriel Saucy, Robert Jacobs, Sarath P. Gunasekera
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Patent number: 5464835Abstract: A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.Type: GrantFiled: February 24, 1994Date of Patent: November 7, 1995Assignees: Harbor Branch Oceanographic Institution, Inc., University of CaliforniaInventors: Oliver J. McConnell, Gabriel Saucy, Robert Jacobs, Sarath P. Gunasekera
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Patent number: 5336757Abstract: A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial agents.Type: GrantFiled: February 7, 1992Date of Patent: August 9, 1994Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Nanda K. Gulavita, Sarath P. Gunasekera, Shirley A. Pomponi, Ross E. Longley, Peter J. McCarthy
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Patent number: 5073572Abstract: Novel acetylenic alcohols were isolated from the known marine sponge Cribrochalina vasculum. These compounds, and derivatives thereof, are useful agents for the treatment of cancers of humans and animals. Also, these compounds and their derivatives can be used as immunosuppressive agents for humans and animals.Type: GrantFiled: February 16, 1990Date of Patent: December 17, 1991Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Glynn T. Faircloth, Amy E. Wright, Winnie C. Thompson, Neal Burres