Patents by Inventor Saravanan Vadivelu
Saravanan Vadivelu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11459338Abstract: The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.Type: GrantFiled: November 23, 2018Date of Patent: October 4, 2022Assignee: JUBILANT EPISCRIBE LLCInventors: Saravanan Vadivelu, Sridharan Rajagopal, Raghunadha Reddy Burri, Shivani Garapaty, Dhanalakshmi Sivanandhan, Manish Kumar Thakur, Tamizharasan Natarajan, Indu N Swamy, Nagendra Nagaraju, Subramaniam Kanagaraj, Zainuddin Mohd, Sayantani Sarkar, Swapan Kumar Samanta, Hariprakash
-
Patent number: 11319326Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: GrantFiled: May 7, 2020Date of Patent: May 3, 2022Assignee: JUBILANT BIOSYS LIMITEDInventors: Saravanan Vadivelu, Sridharan Rajagopal, Murugan Chinnapattu, Pavan Kumar Gondrala, Dhanalakshmi Sivanandhan, Chandrika Mulakala
-
Patent number: 11267820Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.Type: GrantFiled: May 11, 2020Date of Patent: March 8, 2022Assignee: Jubilant Biosys LimitedInventors: Saravanan Vadivelu, Sridharan Rajagopal, Manjunatha M. Ramaiah, Pavan Kumar Gondrala, Murugan Chinnapattu, Dhanalakshmi Sivanandhan, Payal Kiran Parikh, Chandrika Mulakala
-
Publication number: 20210371431Abstract: The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.Type: ApplicationFiled: November 23, 2018Publication date: December 2, 2021Inventors: Saravanan VADIVELU, Sridharan RAJAGOPAL, Raghunadha Reddy BURRI, Shivani GARAPATY, Dhanalakshmi SIVANANDHAN, Manish Kumar THAKUR, Tamizharasan NATARAJAN, Indu N SWAMY, Nagendra NAGARAJU, Subramaniam KANAGARAJ, Zainuddin MOHD, Sayantani SARKAR, Swapan Kumar SAMANTA, Hariprakash N/A
-
Publication number: 20200339595Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, an conditions mediated b one or more BET family of bromodomains.Type: ApplicationFiled: May 11, 2020Publication date: October 29, 2020Applicant: JUBILANT BIOSYS LIMITEDInventors: Saravanan VADIVELU, Sridharan RAJAGOPAL, Manjunatha M. RAMAIAH, Pavan Kumar GONDRALA, Murugan CHINNAPATTU, Dhanalakshmi SIVANANDHAN, Payal Kiran PARIKH, Chandrika MULAKALA
-
Publication number: 20200331926Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: ApplicationFiled: May 7, 2020Publication date: October 22, 2020Applicant: JUBILANT BIOSYS LIMITEDInventors: Saravanan Vadivelu, Sridharan Rajagopal, Murugan Chinnapattu, Pavan Kumar Gondrala, Dhanalakshmi Sivanandhan, Chandrika Mulakala
-
Patent number: 10689395Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: GrantFiled: September 8, 2016Date of Patent: June 23, 2020Assignee: JUBILANT BIOSYS LIMITEDInventors: Saravanan Vadivelu, Sridharan Rajagopal, Manjunatha M. Ramaiah, Pavan Kumar Gondrala, Murugan Chinnapattu, Dhanalakshmi Sivanandhan, Payal Kiran Parikh, Chandrika Mulakala
-
Patent number: 10689390Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: GrantFiled: March 30, 2016Date of Patent: June 23, 2020Assignee: JUBILANT BIOSYS LIMITEDInventors: Saravanan Vadivelu, Sridharan Rajagopal, Murugan Chinnapattu, Pavan Kumar Gondrala, Dhanalakshmi Sivanandhan, Chandrika Mulakala
-
Patent number: 10653673Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.Type: GrantFiled: February 9, 2018Date of Patent: May 19, 2020Assignee: Janssen Pharmaceutica NVInventors: Ishtiyaque Ahmad, Rajagopal Bakthavatchalam, Sivaramakrishna Battula, Henricus Jacobus Maria Gijsen, Saravanan Vadivelu, Mark Wall, Christopher Flores
-
Publication number: 20180282345Abstract: The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: ApplicationFiled: March 30, 2016Publication date: October 4, 2018Applicant: JUBILANT BIOSYS LIMITEDInventors: Saravanan VADIVELU, Sridharan RAJAGOPAL, Murugan CHINNAPATTU, Pavan Kumar GONDRALA, Dhanalakshmi SIVANANDHAN, Chandrika MULAKALA
-
Publication number: 20180237453Abstract: The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.Type: ApplicationFiled: September 8, 2016Publication date: August 23, 2018Applicant: JUBILANT BIOSYS LIMITEDInventors: Saravanan VADIVELU, Sridharan RAJAGOPAL, Manjunatha M. RAMAIAH, Pavan Kumar GONDRALA, Murugan CHINNAPATTU, Dhanalakshmi SIVANANDHAN, Payal Kiran PARIKH, Chandrika MULAKALA
-
Publication number: 20180161312Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.Type: ApplicationFiled: February 9, 2018Publication date: June 14, 2018Inventors: Ishtiyaque Ahmad, Rajagopal Bakthavatchalam, Sivaramakrishna Battula, Henricus Jacobus Maria Gijsen, Saravanan Vadivelu, Mark Wall, Christopher Flores
-
Patent number: 9974775Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.Type: GrantFiled: July 6, 2016Date of Patent: May 22, 2018Assignee: JANSSEN PHARMACEUTICA NVInventors: Ishtiyaque Ahmad, Rajagopal Bakthavatchalam, Sivaramakrishna Battula, Henricus Jacobus Maria Gijsen, Saravanan Vadivelu, Mark Wall, Christopher Flores
-
Publication number: 20160310468Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.Type: ApplicationFiled: July 6, 2016Publication date: October 27, 2016Inventors: Ishtiyaque Ahmad, Rajagopal Bakthavatchalam, Sivaramakrishna Battula, Henricus Jacobus Maria Gijsen, Saravanan Vadivelu, Mark Wall
-
Patent number: 9453002Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.Type: GrantFiled: August 16, 2013Date of Patent: September 27, 2016Assignee: Janssen Pharmaceutica NVInventors: Ishtiyaque Ahmad, Rajagopal Bakthavatchalam, Sivaramakrishna Battula, Henricus Jacobus Maria Gijsen, Saravanan Vadivelu, Mark Wall