Patents by Inventor Sarika Madhukarrao Lunge

Sarika Madhukarrao Lunge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of pregabalin
    Patent number: 10023885
    Abstract: The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitrilas
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: July 17, 2018
    Assignee: Hikal Limited
    Inventors: Swapnil Surendra Mohile, Swapnil Gulabrao Yerande, Sarika Madhukarrao Lunge, Rameshkumar Maghabhai Patel, Shivaji Balbhim Gugale, Rajesh Mataprasad Thakur, Ramesh Ananda Mokal, Ashok Kumar Gangopadhyay, Peter David Nightingale
  • PROCESS FOR THE PREPARATION OF PREGABALIN
    Publication number: 20150344919
    Abstract: The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula pa (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitri
    Type: Application
    Filed: November 4, 2013
    Publication date: December 3, 2015
    Inventors: Swapnil Surendra Mohile, Swapnil Gulabrao Yerande, Sarika Madhukarrao Lunge, Rameshkumar Maghabhai Patel, Shivaji Balbhim Gugale, Rajesh Mataprasad Thakur, Ramesh Ananda Mokal, Ashok Kumar Gangopadhyay, Peter David Nightingale