Patents by Inventor Sarina Grinberg

Sarina Grinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20220249539
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 11, 2022
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Bolaamphiphilic compounds, compositions and uses thereof
    Patent number: 11304964
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: April 19, 2022
    Assignee: Lauren Sciences LLC
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20220072098
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: June 18, 2021
    Publication date: March 10, 2022
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20210106687
    Abstract: Bolaamphiphilic compounds are provided according to formula I: where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 15, 2021
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • NANO-SIZED PARTICLES COMPRISING MULTI-HEADED AMPHIPHILES FOR TARGETED DRUG DELIVERY
    Publication number: 20210023009
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: October 15, 2020
    Publication date: January 28, 2021
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery
    Patent number: 10842747
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: November 24, 2020
    Assignee: Ben-Gurion University of Negev R & D
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20190381137
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: December 19, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20190216895
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2—L1—HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: November 12, 2018
    Publication date: July 18, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20190076533
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 14, 2019
    Inventors: Charles LINDER, Eliahu Heldman, Sarina Grinberg
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20180036376
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 8, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20180021368
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: June 30, 2017
    Publication date: January 25, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • NANO-SIZED PARTICLES COMPRISING MULTI-HEADED AMPHIPHILES FOR TARGETED DRUG DELIVERY
    Publication number: 20170367980
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: May 9, 2017
    Publication date: December 28, 2017
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery
    Patent number: 9642803
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 9, 2017
    Assignee: Ben-Gurion University Of The Negev Research And Development Authority
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20160367678
    Abstract: Bolaamphiphilic compounds are provided according to formula I: where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: April 15, 2016
    Publication date: December 22, 2016
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150306236
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: October 29, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150246138
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2 -L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 3, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150238611
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: August 27, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150110875
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 23, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150104502
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 16, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Nano- and mesosized particles comprising an inorganic core, process and applications thereof
    Patent number: 8377469
    Abstract: Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.
    Type: Grant
    Filed: January 2, 2006
    Date of Patent: February 19, 2013
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Jacob Zabicky, Charles Linder, Sarina Grinberg, Eliahu Heldman