Patents by Inventor Sascha Lutz
Sascha Lutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230304953Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.Type: ApplicationFiled: May 31, 2023Publication date: September 28, 2023Applicant: Roche Diagnostics Operations, Inc.Inventors: Sascha Lutz, Gregor Ocvirk, Christoph Boehm, Wolfgang Burkhardt, Miriam Ruf, Heinz Kontschieder
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Patent number: 11709145Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.Type: GrantFiled: December 9, 2021Date of Patent: July 25, 2023Assignee: Roche Diagnostics Operations, Inc.Inventors: Sascha Lutz, Gregor Ocvirk, Christoph Boehm, Wolfgang Burkhardt, Miriam Ruf, Heinz Kontschieder
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Patent number: 11673138Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.Type: GrantFiled: May 25, 2022Date of Patent: June 13, 2023Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz
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Publication number: 20220280938Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.Type: ApplicationFiled: May 25, 2022Publication date: September 8, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz
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Rotatable cartridge for processing and analyzing a biological sample and dispensing method therewith
Patent number: 11406979Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.Type: GrantFiled: October 11, 2019Date of Patent: August 9, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke -
Patent number: 11369957Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.Type: GrantFiled: August 29, 2018Date of Patent: June 28, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz
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Publication number: 20220196632Abstract: The present disclosure refers to a sensor device, a method of operating the sensor device and an IVD analyzer for receiving the sensor device for determining chemical and/or physical characteristics of a fluid. The sensor device comprises at least two fluidic conduits for repeatedly receiving fluids, each fluidic conduit comprising at least one sensory element arranged such as to come in contact with a fluid in the respective fluidic conduit. In particular, the fluidic conduits comprise different sensory elements, respectively, wherein the sensory elements are separated in the respective fluidic conduits according to compatibility or susceptibility to deterioration or operating temperature. Alternately, the fluidic conduits comprise at least in part the same sensory elements, wherein the sensor device is operated in a primary operating mode and in response to a trigger event, switches to an extended operating mode.Type: ApplicationFiled: December 9, 2021Publication date: June 23, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Miriam Ruf, Sascha Lutz, Heinz Kontschieder, Wolfgang Burkhardt, Gregor Ocvirk
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Publication number: 20220196584Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.Type: ApplicationFiled: December 9, 2021Publication date: June 23, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Sascha Lutz, Gregor Ocvirk, Christoph Boehm, Wolfgang Burkhardt, Miriam Ruf, Heinz Kontschieder
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Publication number: 20210229098Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.Type: ApplicationFiled: April 13, 2021Publication date: July 29, 2021Inventors: Christoph Boehm, Thorsten Brueckner, Thomas Fischer, Eloisa Lopez-Calle, Sascha Lutz, Josef Roedl, Juergen Spinke, Pamela Espindola, Thomas Manuel Keller, Thomas Dolbinow, Sabrina Adler, Erik Beiersdorf, Domenik Wensorra
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Patent number: 11045767Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: GrantFiled: April 25, 2018Date of Patent: June 29, 2021Assignee: Hoffmann-La Roche Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Patent number: 11000848Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.Type: GrantFiled: May 17, 2018Date of Patent: May 11, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thomas Dolbinow, Sabrina Adler, Erik Beiersdorf, Domenik Wensorra, Thorsten Brueckner, Thomas Fischer, Eloisa Lopez-Calle, Sascha Lutz, Josef Roedl, Juergen Spinke, Pamela Espindola, Thomas Manuel Keller
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Publication number: 20210069715Abstract: A cartridge including a structural part with a hole surrounded at least partially by a recess, so that a wall is formed that separates the hole from the recess. The cartridge includes a liquid pack, wherein the liquid pack comprises a surrounding seal portion and a liquid containing portion. The liquid pack is arranged at least partially in the hole, in that a circumferential outer line of the seal portion protrudes over the hole.Type: ApplicationFiled: November 17, 2020Publication date: March 11, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz, Alexander Keuchel
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Patent number: 10677809Abstract: A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.Type: GrantFiled: November 9, 2017Date of Patent: June 9, 2020Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Sascha Lutz, Thomas Keller
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Publication number: 20200149578Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1).Type: ApplicationFiled: April 25, 2018Publication date: May 14, 2020Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20200038858Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.Type: ApplicationFiled: October 11, 2019Publication date: February 6, 2020Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke
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Patent number: 10478817Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.Type: GrantFiled: April 2, 2018Date of Patent: November 19, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke
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Patent number: 10416054Abstract: System and method of determining an amount of an analyte in a blood sample using a cartridge and blood collector are disclosed. The blood collector has a mounting surface, a capillary structure with a curved portion, and a capillary inlet. The cartridge has a receiving surface, a cartridge inlet, a microfluidic structure, and a measurement structure. The method includes placing the blood sample into the capillary inlet; attaching the mounting surface to the receiving surface; rotating the cartridge about a rotational axis to transport the blood sample from the capillary structure to the cartridge inlet and into the microfluidic structure; controlling the rotation of the cartridge to process the blood sample into the processed sample using the microfluidic structure; controlling the rotation of the cartridge to transfer the processed sample to the measurement structure; and measuring the amount of the analyte using the measurement structure and a measurement system.Type: GrantFiled: December 21, 2016Date of Patent: September 17, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz, Bruntje Esrom, Michael Herbel
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Patent number: 10307757Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.Type: GrantFiled: December 6, 2017Date of Patent: June 4, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke
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Patent number: 10213742Abstract: A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present).Type: GrantFiled: March 25, 2013Date of Patent: February 26, 2019Assignee: Hoffmann-La Roche, Inc.Inventors: Norbert Oranth, Nadine Losleben, Sascha Lutz, Adelbert Grossmann
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Publication number: 20180369812Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.Type: ApplicationFiled: August 29, 2018Publication date: December 27, 2018Applicant: Roche Diagnostics Operations, Inc.Inventors: Christoph Boehm, Thorsten Brueckner, Sascha Lutz