Patents by Inventor Sasi Raguram

Sasi Raguram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160370374
    Abstract: This invention relates, in part, to methods and products for the detection of cancer, such as prostate cancer or multiple myeloma. This invention also relates, in part, to methods and products for the detection of prostate disease, such as benign prostatic hyperplasia (BPH). This invention further relates, in part, to methods and products for the detection of specific glycans in one or more samples, such as, for example, methods whereby specific glycans are detected and their amounts analyzed. Such methods can be used to determine relative ratios and/or threshold values for the specific glycans described herein. The relative ratios and/or threshold values can be used in the methods provided.
    Type: Application
    Filed: March 23, 2016
    Publication date: December 22, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Carlos Bosques, Ram Sasisekharan, Sasi Raguram
  • Publication number: 20120289415
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 15, 2012
    Applicants: MOMENTA PHARMACEUTICALS, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram
  • Patent number: 8209132
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: June 26, 2012
    Assignees: Momenta Pharmaceuticals, Inc., Massachusetts Institute of Technology
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram
  • Publication number: 20110201547
    Abstract: The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
    Type: Application
    Filed: January 27, 2011
    Publication date: August 18, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ram Sasisekharan, Karthik Viswanathan, Venkataramanan Soundararajan, Sasi Raguram, Viswanathan Sasisekharan
  • Patent number: 8000904
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: August 16, 2011
    Assignees: Momenta Pharmaceuticals, Inc., Massachusetts Institute of Technology
    Inventors: Nishla Keiser, Carlos Bosques, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram, Aravind Srinivasan
  • Publication number: 20100144553
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Application
    Filed: November 20, 2009
    Publication date: June 10, 2010
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram
  • Publication number: 20100136599
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
    Type: Application
    Filed: October 6, 2009
    Publication date: June 3, 2010
    Applicants: Massachusetts Institute of Technology, Momenta Pharmaceuticals, Inc.
    Inventors: Pankaj Gandhe, Sasi Raguram, Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Ram Sasisekharan
  • Publication number: 20080071148
    Abstract: This invention relates, in part, to methods and products for the detection of cancer, such as prostate cancer or multiple myeloma. This invention also relates, in part, to methods and products for the detection of prostate disease, such as benign prostatic hyperplasia (BPH). This invention further relates, in part, to methods and products for the detection of specific glycans in one or more samples, such as, for example, methods whereby specific glycans are detected and their amounts analyzed. Such methods can be used to determine relative ratios and/or threshold values for the specific glycans described herein. The relative ratios and/or threshold values can be used in the methods provided.
    Type: Application
    Filed: April 3, 2007
    Publication date: March 20, 2008
    Applicant: Massachusetts Institute of Technology
    Inventors: Carlos Bosques, Ram Sasisekharan, Sasi Raguram
  • Publication number: 20060127950
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Application
    Filed: October 6, 2005
    Publication date: June 15, 2006
    Applicants: Massachusetts Institute of Technology, Parivid LLC
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram
  • Publication number: 20060057638
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
    Type: Application
    Filed: April 15, 2005
    Publication date: March 16, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram