Patents by Inventor Saskia Zemolka

Saskia Zemolka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine Compounds
    Publication number: 20170313703
    Abstract: Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the ?-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 2, 2017
    Inventors: Klaus LINZ, Saskia ZEMOLKA, Bert NOLTE, Stefan SCHUNK, Hans SCHICK
  • Cis-tetrahydro-spiro(cyclohexane-1, 1' -pyrido[3,4-b]indole)-4-amine Compounds
    Publication number: 20160159787
    Abstract: Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the ?-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.
    Type: Application
    Filed: September 4, 2015
    Publication date: June 9, 2016
    Inventors: Klaus LINZ, Saskia ZEMOLKA, Bert NOLTE, Stefan SCHUNK, Hans SCHICK
  • Spirocyclic cyclohexane compounds
    Patent number: 8404740
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: March 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
  • Spirocyclic azaindole derivatives
    Patent number: 8399503
    Abstract: The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 19, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Ellen Bergrath, Babette-Yvonne Kögel, Werner Englberger, Klaus Linz, Hans Schick
  • Substituted cyclohexyldiamines
    Patent number: 8357705
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain or other conditions.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: January 22, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Bert Nolte, Klaus Linz, Derek John Saunders, Wolfgang Schröder, Werner Englberger, Fritz Theil, Hans Schick, Jens Kaufmann, Julian Gebauer, Helmut Sonnenschein
  • Substituted spirocyclic cyclohexane derivatives
    Patent number: 8293758
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 23, 2012
    Assignee: Grunenthal GmbH
    Inventors: Saskia Zemolka, Bert Nolte, Sven Frormann, Claudia Hinze, Klaus Linz, Wolfgang Schröder, Werner Englberger, Hans Schick, Helmut Sonnenschein
  • Hydroxymethylcyclohexylamines
    Patent number: 8288406
    Abstract: The invention relates to compounds which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: October 16, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Sven Frormann, Saskia Zemolka, Klaus Linz, Werner Englberger, Fritz Theil
  • Spiro(5.5)undecane derivatives
    Patent number: 8288430
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 16, 2012
    Assignee: Grunenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Klaus Linz, Wolfgang Schröder, Werner Englberger, Fritz Theil, Birgit Roloff
  • Substituted heteroaryl derivatives
    Patent number: 8138187
    Abstract: The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 20, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Werner Englberger, Babette-Yvonne Kögel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Heinz Graubaum, Claudia Hinze
  • Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds
    Publication number: 20120029006
    Abstract: Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the ?-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.
    Type: Application
    Filed: July 28, 2011
    Publication date: February 2, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Klaus Linz, Saskia Zemolka, Bert Nolte, Stefan Schunk, Hans Schick
  • Substituted propiolic acid amides and their use for producing drugs
    Patent number: 8008304
    Abstract: The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: August 30, 2011
    Assignee: Grüenthal GmbH
    Inventors: Michael Haurand, Klaus Schiene, Sven Kühnert, Melanie Reich, Saskia Zemolka
  • (Hetero)aryl cyclohexane derivatives
    Patent number: 7977370
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: July 12, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Bert Nolte, Klaus Linz, Wolfgang Schröder, Werner Englberger, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, József Bálint
  • Hydroxymethylcyclohexylamines
    Publication number: 20110059999
    Abstract: The invention relates to compounds which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 10, 2011
    Applicant: GRÜNENTHAL GMBH
    Inventors: Sven Frormann, Saskia Zemolka, Klaus Linz, Werner Englberger, Fritz Theil
  • Substituted imidazo[2,1-b]thiazole compounds and uses thereof
    Patent number: 7893069
    Abstract: Substituted imidazo[2,1-b]thiazole compounds corresponding to formula I, a method for producing them, pharmaceutical compositions containing them, and the use thereof for regularing mGluR5 receptors, or for treating or inhibiting disorders or disease states at least partially mediated by mGluR5 receptor such as pain, anxiety attacks, drug or alcohol dependency, and others.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: February 22, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kuehnert, Saskia Zemolka, Michael Haurand, Klaus Schiene
  • Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics
    Patent number: 7696238
    Abstract: Substituted benzo[d]isoxazol-3-yl amine compounds corresponding to formula I which exhibit an strong affinity to the KCNQ2/3 K+ channel, and which are suitable for treating or inhibiting pain and/or disorders or disease states that are at least partly mediated by the KCNQ2/3 K+ channel.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: April 13, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Robert Frank, Gregor Bahrenberg, Wolfgang Schroeder, Saskia Zemolka
  • Spirocyclic Cyclohexane Compounds
    Publication number: 20100048554
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Stefan Schunk, Saskia Zemolka, Derek Saunders, Michael Gruss, Heinz Graubaum
  • SUBSTITUTED HETEROARYL DERIVATIVES
    Publication number: 20100009986
    Abstract: The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.
    Type: Application
    Filed: July 17, 2007
    Publication date: January 14, 2010
    Applicant: GRUNENTHAL GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Werner Englberger, Babette-Yvonne Kögel, Klaus Link, Hans Schick, Helmut Sonnenschein, Heinz Graubaum, Claudia Hinze
  • (HETERO)ARYL CYCLOHEXANE DERIVATIVES
    Publication number: 20090247573
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: GRUNENTHAL GMBH
    Inventors: Saskia Zemolka, Stefan Schunk, Bert Nolte, Klaus Linz, Wolfgang Schroder, Werner Englberger, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Jozsef Balint
  • SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES
    Publication number: 20090247561
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GmbH
    Inventors: Saskia Zemolka, Bert Nolte, Sven Frorman, Claudia Hinze, Klaus Linz, Wolfgang Schroder, Werner Englberger, Hans Schick, Helmut Sonnenschein
  • SPIRO(5.5)UNDECANE DERIVATIVES
    Publication number: 20090247505
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: Grunenthal GMBH
    Inventors: Saskia ZEMOLKA, Stefan SCHUNK, Klaus LINZ, Wolfgang SCHRODER, Werner ENGLBERGER, Fritz THEIL, Birgit ROLOFF