Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: The present disclosure concerns a sensor for detecting a sample analyte having an oxidizable phenolic group suspected to be present in a sample. The sensor comprises a sensing electrode, a plurality of sensor analytes associated with the sensing electrode, optionally a baseline electrode, and a sample receiving region in fluid communication with the sensing electrode. The sensor analyte, before its association with the sensing electrode, is the same chemical species as the sample analyte.

Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Abstract: Techniques are described for a hierarchical caching mechanism enabling efficient cross-region replications. In some embodiments, replication-related information (e.g., key-value pairs) is stored in a particular layout in a binary tree (B-tree) of a file system for replication processing. A hierarchy of caches storing a first type of information (e.g., crypto keys associated with iNodes) may be arranged to match the particular layout in the B-tree to enable efficient parallel processing of a second type of information (e.g., files, file data, or symbolic links), where the replication-related information in the B-tree is partitioned into multiple key ranges for parallel processing. In some embodiments, the caches in different hierarchies may be shared by different parallel-processing key ranges and replication jobs in a file system.

Abstract: An optical transceiver includes a built-in optical switch to switch between diverse fiber paths in switches in a datacenter or in switches between two datacenters. The built-in optical switch can be used to switch between racks in a datacenter to increase capacity for any rack that requests it. A controller, which receives a signal from a server computer in one of the racks, can be external to the optical transceiver or within the optical transceiver. In either case, the server computer can be provided with additional bandwidth when needed. For connections between datacenters, the built-in optical switch allows for optical line protection, but without the need for a splitter circuit, which incurs a significant power loss and requires a more expensive transceiver. Consequently, the built-in optical switch within an optical transceiver can be used in a variety of contexts to increase efficiency and reduce overall costs for network devices.

Abstract: Systems, computer program products, and methods are described herein for optimized data archival using data detection and classification model. The present invention is configured to receive information associated with a first data element within a distributed network environment; determine a first data type associated with the first data element; determine one or more archival actions associated with the first data element; determine one or more archival requirements associated with the first data element; determine one or more utilization parameters associated with the first data element; initiate an execution of the one or more archiving actions on the first data element; determine that the one or more archival actions meet the one or more archival requirements associated with the first data element; and execute the one or more archiving actions based on at least determining that the one or more archival actions meet the one or more archival requirements.

Abstract: The present subject matter discloses a system and method for detecting Large Vessel Occlusion (LVO) on a Computational Tomography Angiogram (CTA) automatically. the system comprises a vascular-territory-segmentation module, an ICV segmentation module, MCA-LVO classifier and ICA-LVO classifier. The vascular territory segmentation module is configured to receive a set of CTA images and to mark a territory of vascular segments in the ICV region for each slice of the ROI. The ICV segmentation module is configured to process each slice of the ROI. The processed slices of the ROI are combined to develop a CTA image after application of MIP and the developed CTA image is segmented into a Middle Cerebral Artery (MCA) region and an Internal Cerebral Artery (ICA) region. The MCA-LVO and ICA-LVO classifiers determine presence of the LVO on the received MCA and ICA region using Deep Learning techniques and accordingly the presence of the LVO is reported.

Abstract: Symmetric networking techniques disclosed herein can be applied by gateway routers in cloud networks. The techniques can ensure that both outbound traffic received at a cloud from a branch device and return traffic directed from the cloud back to the branch device are processed by a same gateway router. The gateway router can use network address translation to insert IP addresses from an inside pool and an outside pool assigned to the router.

Abstract: Circuits and methods for selectable conversion ratio power converters that include low-dropout (LDO) power supplies adapted to select voltage inputs based on the selected conversion ratio while achieving high efficiency. The LDO power supplies limit current through power FETs of power converters, thereby mitigating or eliminating potentially damaging events. In some embodiments, first and second full gate-drive LDOs have “wired-OR” outputs which may power a target circuit such as a pre-driver (and optionally, a level-shifter) coupled to the gate of a power FET. In some embodiments, first and second reduced gate-drive LDOs have “wired-OR” outputs that may power a final driver coupled to the gate of a power FET. Some embodiments have dual full gate-drive LDOs that power a target circuit such as a pre-driver (and optionally, a level-shifter), while dual reduced gate-drive LDOs that power a final driver coupled to the gate of the power FET.

Abstract: The present invention relates to a system and a method for updating data models. Input data received from a data source and/or prediction data obtained from a data model is reduced based on baseline reference data to obtain a plurality of representative points. The plurality of representative points are clustered to generate a plurality of clusters. An outlier cluster is detected from the plurality of clusters based on a maximum distance of the plurality of clusters from a highest density cluster and/or comparison of quantity and values of the plurality of representative points with predefined rules. Data drift is identified based on changes in densities of the plurality of clusters. The data model is updated using information corresponding to the outlier cluster and the data drift.

Abstract: An apparatus, method, and computer program product are provided for the improved and automatic prediction and modeling of one or more channels and relevant conditions through which resources may be directed to users in an environment where resource demand, utility, and perceived value vary over time. Some example implementations employ predictive, machine-learning modeling to facilitate the use of multiple disparate and unrelated data sets to extrapolate and otherwise predict the future needs for certain resources and identify the channels and conditions that may be employed to meet such future needs. An apparatus, method, system, and computer program product are provided for improved generating, adjusting, and/or facilitating approval of a resource offer set. Some example implementations employ one or more predictive models.

Abstract: Illustrative systems and methods enable a virtual machine (“VM”) to be powered up at any hypervisor regardless of hypervisor type, based on live-mounting VM data that was originally backed up into a hypervisor-independent format by a block-level backup operation. Afterwards, the backed up VM executes anywhere anytime without needing to find a hypervisor that is the same as or compatible with the original source VM's hypervisor. The backed up VM payload data is rendered portable to any virtualized platform. Thus, a VM can be powered up at one or more test stations, data center or cloud recovery environments, and/or backup appliances, without the prior-art limitations of finding a same/compatible hypervisor for accessing and using backed up VM data. An illustrative media agent maintains cache storage that acts as a way station for data blocks retrieved from an original backup copy, and stores data blocks written by the live-mounted VM.

Abstract: Techniques are described for snapshot key inter-dependency resolution during cross-region replications. Dependency between a first type of replication-related information (e.g., crypto keys associated with a parent directory iNode or a file iNode) and a second type of replication-related information (e.g., files, file data/FMAPs, or symbolic links) during a cross-region replication may be resolved to enable non-blocking delta application in a target file system. In some embodiments, temporary dummy entries for the first type of information may be created in the B-tree of the target file system for the out-of-order download (e.g., the second type being downloaded before the first type) of these two types of information. In some embodiments, a consolidation process may be performed between the dummy entries and the later-arriving first type of information.

Abstract: The Fleetwide Adaptive Rate Limiting Gatekeeper Apparatuses, Processes and Systems (“FARLG”) transforms API call permission request, API call result request datastructure/inputs via FARLG components into API call permission response, API call result response outputs. An API call permission request datastructure associated with an API call of an application structured to identify an API and a set of scopes is obtained. A retry-after interval is determined for each scope in the set of scopes, in which existence of a retry-after interval for a scope indicates that the API previously returned a throttled response for the scope. A wait duration associated with the API call is determined as the maximum retry-after interval across retry-after intervals that exist for the set of scopes. An API call permission response datastructure structured to specify the wait duration is provided.

Abstract: Techniques are described for enabling concurrent and non-blocking replication object deletion during cross-region replications. In some embodiments, in a target file system, a target replication pipeline as part of a cross-region replication, and a deletion pipeline operate in parallel. The deletion pipeline deletes processed objects reaching the last pipeline stage of the target replication pipeline after each checkpoint in the target replication pipeline. In some embodiments, after a non-recoverable failure during the cross-region replication, the cross-region replication can be restarted from the beginning (i.e., fresh restart) without waiting for its unused objects in the Object Store to be deleted by utilizing a generation number associated with each object to delete the unused objects in a background process while allowing deleting processed objects as normal for the freshly restarted cross-region replication.

Abstract: Circuits and methods that limit current through power FETs of power converter to reduce damaging current in-rush events, independent of switching frequency, device mismatches, and PVT variations. Embodiments utilize a closed-loop feedback circuit and/or a calibrated compensation circuit to regulate, substantially independent of frequency, the control voltage VGATE applied to a power FET gate. In a reduced gate-drive mode, connecting a feedback or compensation circuit to the gate of an LDO source-follower FET allows the gate voltage to be regulated to control the LDO output voltage to a final inverter coupled to the gate of a power FET so that VGATE is adjusted to provide a reduced gate-drive to the power FET; connecting to the output of the LDO allows the LDO output voltage to the final inverter to be directly regulated to adjust VGATE; connecting to the gate of the power FET allows VGATE to be directly set.

Abstract: Systems and methods for detecting electrical connection and disconnection on an USB Type-A charging port like power adapters, power banks and car chargers having one or more USB Type-A charging port of an USB device. The system includes: a voltage source; a MOSFET SWITCH gate driver, in USB type-A connected state, that operatively couples MOSFET SWITCH with voltage source and VBUS supply of USB type-A port; charge pump; a current sense differential amplifier; and a control unit configured to: monitor VBUS current, and detect potential disconnected state of connected USB type-A port; and monitor VBUS voltage and compare VBUS voltage with predetermined voltage to sense external condition such that VBUS voltage drops because of load capacitance and load current. The control unit is further configured to, when the duty cycle has reached a minimum VBUS current, detect the USB type-A disconnection with a charge pump state.

Abstract: The present disclosure provides a DFT architecture for ICs and a method for testing the ICs with the proposed DFT architecture. The present disclosure also includes a focus on USB PD protocol with respect to the DFT architecture. The present disclosure also includes focus on testing IC with single I/O pin. The DFT architecture primarily comprises of a test mode controller and reuses the USBPD protocol framework logic comprising analog USBPD CC circuitry in analog block and the USBPD signaling, protocol logic in digital block for the test purposes. The DFT architecture is implemented with analog test modes and digital test modes using a single I/O pin, wherein analog test modes comprises of analog trims and observation modes and digital test modes comprises of LBIST, ATPG and digital observation modes. The method disclosed is directed to the functions associated with testing the USBPD ICS using single I/O pin.

Abstract: Techniques are described for enabling replication-aware resource management and task management in a cloud infrastructure for cross-region replication. In some embodiments, each replication job is associated with a set of replication-related information. In certain embodiments, the replication-aware resource management allocates resources, using a combination of various resource allocation schemes, to a fleet of replicators to allow the fleet to select replication jobs in a job queue, and perform resource scaling based on monitored performance metrics reported by the fleet. In some embodiments, the replication-aware task management enables replication job selection based on the set of replication-related information to optimize the performance of all cross-region replications in the region.

Abstract: A method for processing NF discovery requests using prioritized lists of preferred locations includes maintaining an NF profiles database including NF profiles of producer NFs registered to provide service to other NFs and a preferred locality attribute mappings database including mappings between preferred locality attributes and prioritized lists of preferred locations. The method includes receiving, from an NF, an NF discovery request including query parameters and a preferred locality attribute. The method further includes accessing the preferred locality attribute mappings database using the preferred locality attribute and obtaining a prioritized list of preferred locations corresponding to the preferred locality attribute, accessing the NF profiles database using the query parameters and identifying NF profiles of producer NFs capable of providing a service indicated by the query parameters, and prioritizing the NF profiles according to the prioritized list of preferred locations.