Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..

Abstract: Monoclonal antibodies exhibiting specificity for human TNF-.alpha. are disclosed. The antibodies are useful for immunological purification and for measurement of said human TNF-.alpha. in immunoassays.

Abstract: Interleukin-1.alpha. (IL-1-.alpha.) and derivatives, and their pharmaceutical compositions for use in treating arthritis or inflammation.

Abstract: Interleukin-1.beta. (IL-1.beta.) and derivatives, and their pharmaceutical compositions for use in treating arthritis or inflammation.

Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

Abstract: An autonomous, decentralized fast breeder reactor includes a single reactor main vessel which houses a plurality of small-size reactor subsystems each having a small-scale fast breeder reactor core, and a plurality steam generator subsystems. These subsystems function in an autonomous manner and are caused to undergo a heat transfer with one another by a coolant circulating naturally through the interior of the main vessel, thereby constructing a cooperatively operating system. Steam generated by the steam generators is introduced to a turbine system and utilized in generating electricity. The condensate from the turbines is cooled by a heat accumulating pool, and the heat is utilized in a separate system. The entire system is installed underground and use is made of the difference in elevation. Use also is made of solid bedrock to construct a housing facility for the reactor.

Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..

Abstract: This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. ##STR1## wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence ##STR2## or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.

Abstract: A heat pipe type heat exchanger, such as a steam generator for use in combination with a fast breeder reactor, comprises two double walls consisting of an outer wall and an inner wall and of an outer wall and an inner wall, respectively, and a plurality of double tubes each consisting of an inner tube and an outer tube coaxially receiving the inner tube therethrough. A heating fluid flows through spaces between the outer tubes and the inner walls of the double walls, while a heated fluid flows through the inner tubes. A heat transfer medium is contained in evaporating spaces each defined by the inner surface of the outer tube and the outer surface of the inner tube. The heat transfer medium is evaporated by the heat of the heating fluid, condenses over the surfaces of the inner tubes to transfer heat to the heated fluid flowing through the inner tubes. Each evaporating space is partitioned into many sections by baffle plates to enhance the heat flux in the evaporating space.

Abstract: This invention provides a novel cultured cell line which is derived from human T leukemic cells and which produces a colony-stimulating factor (CSF). This invention also provides a process for preparing such human cultured cell line, and a process of producing a CSF from such cell line.