Abstract: An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT5A receptor modulating action. It was confirmed that a bicyclic acylguanidine derivative which has a characteristic structure that guanidine is bonded to one ring of a bicyclic structure such as chromene and dihydronaphthalene through a carbonyl group and a cyclic group is bonded on the other ring, has a potent 5-HT5A receptor modulating action and an excellent pharmacological action based on this mechanism. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder.

Abstract: The present invention provides a machine tool making it possible that an operator needs to remove a key member from a predetermined position after an unlock condition of a door is established when a door lock mechanism brings the door into an unlocked state, meanwhile the operator can recognize the necessity of reattaching the key member to the predetermined position when the door lock mechanism brings the door into a locked state. In the machine tool, an interlock mechanism 5a allows a door lock mechanism 8 to bring a door 3 into the unlocked state in a state that the unlock condition of the door 3 is established and when the key member 9 is removed from the predetermined position and, after the door 3 is unlocked, allows the door lock mechanism 8 to bring the door 3 into the locked state only when the key member 9 is attached to the predetermined position in a state that the door closed state detection mechanism 7 detects that the door is located at the predetermined closed position.

Abstract: There are provided a machine tool cooling system and cooling method which allow cost reduction by reducing the number of control valves, and in which opening/closing control is simple. The machine tool cooling system and cooling method include a hot oil tank 4 storing hot oil, a cold oil tank 5 storing cold oil, a first to third hot oil passages 9a to 9c and a first to third cold oil passages 10a to 10c, which supply the hot oil and the cold oil to a first to third heat generating portions 1 to 3, a hot oil return passage 11 returning the hot oil to the hot oil tank 4, a first to third supply control valves 16a to 16c interposed in the first to third cold oil passages 10a to 10c, and a valve controller 8 controlling opening/closing of the first to third supply control valves 16a to 16c so that the cold oil is supplied to the first to third heat generating portions 1 to 3 intermittently at different timings.

Abstract: A notebook information processor includes a lid including an image photographing unit and a display, and a main body, wherein the control unit includes a live view displaying unit that displays a live view obtained by photographing at least a portion of the main body within a photographing area of the image photographing unit on the display, a rectangle detecting unit that detects a rectangle for calculating a projective transformation parameter from the live view, a projective transformation parameter calculating unit that calculates the projective transformation parameter from a coordinate of the rectangle, and a still image obtaining unit that performs a projective transformation on the live view so as to obtain a live view photographed from a front direction, using the projective transformation parameter, obtains a still image from the live view after the projective transformation, and stores the still image in the storage unit.

Abstract: A notebook information processor includes an image photographing unit, a display, a keyboard, a storage unit, and a control unit, wherein the control unit includes, a live view displaying unit that displays a live view obtained by photographing at least a portion of the keyboard within a photographing area of the image photographing unit on the display, a still image obtaining unit that obtains a still image from the live view displayed on the display by the live view displaying unit, when receiving a photographing start signal to start photographing the still image of a document put on the keyboard, and an image processing unit that performs projective transformation on the still image obtained by the still image obtaining unit so as to obtain an image photographed from a front direction, executes image processing so as to perform cropping to clip the document, and stores a transformed image of the document after the image processing in the storage unit.

Abstract: Document image data is converted into luminance image data. Block image data is generated from the luminance image data. Start point block pixel data and end point block pixel data are set based on a change rate of luminance values of adjacent block pixel data. A luminance value of block pixel data between the start point block pixel data and the end point block pixel data is corrected based on a start point luminance value and an end point luminance value. The luminance value, of the block pixel data wherein each luminance value of an adjacent block pixel data cluster is less than an average value, is substituted by the average value. The luminance value of each pixel data is set based on the luminance value of the block pixel data. Post process luminance image data that includes each pixel data is reconverted into the document image data.

Abstract: An original is inclined with respect to an optical axis of a camera until the camera is positioned outside a reflected-image taking range by inclining a mounting surface of an original glass on which the original is placed. This makes it possible, when the original is taken by the camera, to prevent the camera from being reflected on the original and being taken in with the original. An imaging case formed of a diffusing member that is made of a high light-diffusing material or a high light-absorbing material is arranged in the reflected-image taking range. This makes it possible to prevent an object positioned in the reflected-image taking range from being reflected on the original and being taken by the camera. Consequently, clear image information can be more reliably obtained.

Abstract: An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia and the like, based on the 5-HT5A receptor modulating action. It was confirmed that a compound characterized by a structure that a tricyclic hetero ring having a pyrrole ring at the center and guanidine are bonded via a carbonyl group has a potent 5-HT5A receptor modulating action and an excellent pharmacological action based thereon, and thus, it was found that the compound can be an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder, particularly for memory-related functional disorders such as cognitive impairments including dementia and schizophrenia, thereby completing the present invention.

Abstract: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).

Abstract: A machining system 1 comprises a lathe 10 having end portion supporting mechanisms 13, 15 for supporting an elongated workpiece W horizontally, center rests 21 for supporting the middle portion of the workpiece W, an adjustment mechanism for adjusting the supported position of the workpiece W by adjusting the height positions of the center rests 21, a tool rest 20, and a control device 25, and a non-contact measuring device 30 for measuring the deflection amount of the workpiece W at portions thereof supported by the center rests 21 when the workpiece W is rotated. The control device 25 is configured to adjust the height positions of the center rests 21 by controlling the adjustment mechanism on the basis of the measured deflection amount, so that the height positions of both end portions of the workpiece W being rotated and the middle portion thereof become the same.

Abstract: The present invention relates to a machining system etc. capable of highly accurately machining a workpiece even in a case where the workpiece is deflected. A machining system 1 is configured with a lathe 10 having end portion supporting mechanisms 13, 15 for supporting both end portions of an elongated workpiece W horizontally, a tool rest 20 for holding a tool, a feed mechanism for moving the tool rest 20 in three orthogonal directions, and a control device 25 for controlling the feed mechanism, and a non-contact measuring device 30 for measuring the deflection shape of the workpiece W when the workpiece W is rotated. The control device 25 moves the tool along the deflection shape measured by the non-contact measuring device 30.

Abstract: Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N?-phenyl-N?-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N?-bis (4-fluorophenyl)-N?-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.

Abstract: A solid-concentration measuring apparatus includes an ultrasonic transmitter, an ultrasonic receiver, and a response-time integrator. The ultrasonic transmitter transmits a single-pulse ultrasonic wave to a liquid toner. The ultrasonic receiver receives the single-pulse ultrasonic wave. The ultrasonic transmitter transmits again a single-pulse ultrasonic wave after a predetermined time has passed from when the ultrasonic receiver receives the single-pulse ultrasonic wave. The response-time integrator measures a response time from transmission to reception of each single-pulse ultrasonic wave, and integrates the response time with respect to each set of N pulses (N>1). A solid concentration of the liquid toner is calculated based on the integrated response time.

Abstract: An image processing apparatus including an image photographing unit, and a control unit, wherein the control unit includes a document image acquiring unit that acquires a document image including at least an image of a document, a contour extracting unit that extracts a contour of the document from the document image, the extracting the contour being performed based on luminance, a distortion position detecting unit that detects a contour straight line located at a location where a distance between the contour and a center point of a rectangle having the minimum area surrounding the contour is shortest, the contour straight line being detected as a distortion position in the document, the contour straight line being located on the contour, and a corrected image generating unit that performs a geometric correction on the document image to extend the contour to a correction reference line determined from the distortion position, and generates a corrected image having the distortion in the document image correct

Abstract: A ligature and suture device for medical application that ligatures or sutures biomedical tissue that has been suctioned by a suction device using a suturing member. The ligature and suture device includes an insertion portion having a lumen into which an endoscope can be inserted, and a distal end portion that is connected to the lumen and in which at least one side aperture is provided, at least one hollow needle that is able to support inside itself the suturing member, and that is placed inside the insertion portion such that a tip of the hollow needle is able to move between a first position, which is on a base end side of the side aperture, and a second position, which is on a distal end side of the side aperture, an operating section that performs an operation to move the needle, and at least one pledget that can be penetrated by the needle, and that is placed in a vicinity of the distal end of the side aperture so as to be freely removable from the distal end portion.

Abstract: A biological tissue is sutured or ligatured, a suture and ligature member such as a ligature wire is cut, and then a holding member is reliably recovered from the body. In a holding member of a medical ligature tool, a protrusion is disposed between distal lateral holes, and proximal lateral holes, so that it protrudes outward in a diameter direction thereof. On the other hand, a concave portion is formed in the inner periphery of a cutting member. When the cutting member is extended to cut a ligature wire, the concave portion is fitted to the protrusion to allow the holding member to engage the cutting member.

Abstract: An endoscopic treatment system 1 of the present invention includes an overtube 2 that is inserted into the body of a patient. An endoscope 7 and a suturing device 8 are inserted into the overtube 2. The overtube 2 has a long and flexible tube main body 3, and a chamber 4 is provided at the distal end of the tube main body 3. The chamber 4 has a lateral hole 10 formed on the lateral surface thereof. The width of the lateral hole 10 is set such that a lesion can be drawn into the lateral hole 10 while preventing other organs on the periphery of the lesion from being drawn into the lateral hole 10.

Abstract: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).

Abstract: A notebook information processor includes an image photographing unit, a display, a keyboard, a storage unit, and a control unit, wherein the control unit includes, a live view displaying unit that displays a live view obtained by photographing at least a portion of the keyboard within a photographing area of the image photographing unit on the display, a still image obtaining unit that obtains a still image from the live view displayed on the display by the live view displaying unit, when receiving a photographing start signal to start photographing the still image of a document put on the keyboard, and an image processing unit that performs projective transformation on the still image obtained by the still image obtaining unit so as to obtain an image photographed from a front direction, executes image processing so as to perform cropping to clip the document, and stores a transformed image of the document after the image processing in the storage unit.

Abstract: A notebook information processor includes a lid including an image photographing unit and a display, and a main body, wherein the control unit includes a live view displaying unit that displays a live view obtained by photographing at least a portion of the main body within a photographing area of the image photographing unit on the display, a rectangle detecting unit that detects a rectangle for calculating a projective transformation parameter from the live view, a projective transformation parameter calculating unit that calculates the projective transformation parameter from a coordinate of the rectangle, and a still image obtaining unit that performs a projective transformation on the live view so as to obtain a live view photographed from a front direction, using the projective transformation parameter, obtains a still image from the live view after the projective transformation, and stores the still image in the storage unit.