Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: An object of the present invention is to provide a cerium oxide (CeO2)-zirconium oxide (ZrO2)-aluminum oxide (Al2O3)-based complex oxide having an improved heat resistance and a method of producing the complex oxide, and the present invention provides a complex oxide containing a cerium element, a zirconium element, an aluminum element, and optionally a rare earth metal element other than a cerium element, wherein a specific surface area measured by a BET method after heat treatment in an air atmosphere at 1000° C. for 25 hours is 60 m2/g or more, and a method of producing the complex oxide.

Abstract: A system for detecting an object collision includes a processor and a memory in communication with the processor with an objection collision detection module. The objection collision detection module has instructions that, when executed by the processor, cause the processor to obtain a first image and a second image of a scene from a camera sensor mounted to a vehicle, determine a change amount between the first image and the second image, and based on the change amount, determine at least one of that an object is approaching the vehicle or the object has collided with the vehicle. The change amount represents the number of pixels with the same location value that changed intensity values between the first and second images.

Abstract: Systems and methods are provided for monitoring and mapping a theft of a target vehicle. One method includes grouping a plurality of vehicles in communication with a network to collectively monitor and collect evidence of theft of the target vehicle using camera sensors located in each of the plurality of vehicles. The network is operably connected with at least one processor. At least one input from at least one camera sensor of the plurality of vehicles is obtained and analyzed to determine a direction of travel of the target vehicle. The method includes generating a digital map including an indication of a location and a trajectory based on the direction of travel of the target vehicle. The method provides a communication to a law enforcement agency or a user, with the communication including the digital map.

Abstract: Systems, methods, and other embodiments described herein relate to improving vehicle monitoring using collaboration of nearby devices. In one embodiment, a method includes, responsive to receiving identifying information about a target vehicle in a monitoring device, detecting the target vehicle near to the monitoring device. The method includes acquiring monitoring information about the target vehicle. The method includes providing the monitoring information to a remote device.

Abstract: A system for detecting an object collision includes a processor and a memory in communication with the processor with an objection collision detection module. The objection collision detection module has instructions that, when executed by the processor, cause the processor to obtain a first image and a second image of a scene from a camera sensor mounted to a vehicle, determine a change amount between the first image and the second image, and based on the change amount, determine at least one of that an object is approaching the vehicle or the object has collided with the vehicle. The change amount represents the number of pixels with the same location value that changed intensity values between the first and second images.

Abstract: Systems and methods are provided for monitoring and mapping a theft of a target vehicle. One method includes grouping a plurality of vehicles in communication with a network to collectively monitor and collect evidence of theft of the target vehicle using camera sensors located in each of the plurality of vehicles. The network is operably connected with at least one processor. At least one input from at least one camera sensor of the plurality of vehicles is obtained and analyzed to determine a direction of travel of the target vehicle. The method includes generating a digital map including an indication of a location and a trajectory based on the direction of travel of the target vehicle. The method provides a communication to a law enforcement agency or a user, with the communication including the digital map.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Systems and methods are provided for monitoring a group of vehicles for suspicious activity. The method includes grouping a plurality of vehicles in communication with a network to collectively monitor and detect evidence of theft or unauthorized intrusion using existing theft detection sensors located in the plurality of vehicles. One of the plurality of vehicles is designated as a master vehicle responsible for managing at least one control feature, and is operably coupled to the network and at least one processor. At least one input from at least one theft detection sensor of the plurality of vehicles is obtained and analyzed for suspicious information. The method includes determining that the input represents or contains evidence indicative of a theft or unauthorized intrusion. A communication is then provided to at least one of another vehicle, a vehicle owner, and the network indicating a potential theft or unauthorized intrusion.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Systems and methods are disclosed and include receiving, using an electronic control module of a vehicle, image data from a camera system. The method includes identifying, using the electronic control module, a traffic sign based on the image data and information from a training database. The method includes determining, using the electronic control module, whether the traffic sign is correct based on a matching of the traffic sign and an entry of at least one of (i) a traffic rules database, (ii) a traffic customs database, (iii) a map information database, and (iv) a global positioning system (GPS) information database. The method includes identifying, in response to determining that the traffic sign is correct, a vehicle action from a vehicle action database corresponding to the traffic sign. The method includes outputting, in response to validating the vehicle action, a signal to a vehicle control module corresponding to the vehicle action.

Abstract: A vehicle communication system includes an onboard apparatus, a mobile device, and a key issuing apparatus provided outside the vehicle for issuing a key for cryptographic communication between the mobile device and the onboard apparatus. The mobile device and the onboard apparatus store the key, and perform the cryptographic communication using the key. The key issuing apparatus issues, to the onboard apparatus, the key and validity information indicating validity of the key. The onboard apparatus includes a determination section determining whether a validity ends, and an update request section transmitting a key update request to request the issuance of a new key. When the key update request has been received, the key issuing apparatus issues a new key to the mobile device, and issues a new key and validity information on the new key to the onboard apparatus.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Systems and methods are disclosed and include receiving, using an electronic control module of a vehicle, image data from a camera system. The method includes identifying, using the electronic control module, a traffic sign based on the image data and information from a training database. The method includes determining, using the electronic control module, whether the traffic sign is correct based on a matching of the traffic sign and an entry of at least one of (i) a traffic rules database, (ii) a traffic customs database, (iii) a map information database, and (iv) a global positioning system (GPS) information database. The method includes identifying, in response to determining that the traffic sign is correct, a vehicle action from a vehicle action database corresponding to the traffic sign. The method includes outputting, in response to validating the vehicle action, a signal to a vehicle control module corresponding to the vehicle action.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A production method comprising: adding a hydroxycarboxylic acid to an aqueous solution containing a Ce salt, a Zr salt, an Al salt, and at least one selected from a La salt, an Mg salt, and a Ca salt, to produce a gel, heating the gel to obtain a solid product by decomposition of the salts, firing the solid product to obtain a fired product containing a ceria-zirconia-based regular array phase precursor and an aluminate-based composite oxide precursor, performing a reducing heat treatment of the fired product to obtain a first composite having mutually dispersed therein a pyrochlore phase and an aluminate-based composite oxide, and performing an oxidizing heat treatment of the first composite to obtain a second composite in which at least part of the pyrochlore phase is transformed into a ? phase; and an oxygen storage material having mutually dispersed therein the composite oxide and the regular array phase.

Abstract: A vehicle communication system includes an onboard apparatus, a mobile device, and a key issuing apparatus provided outside the vehicle for issuing a key for cryptographic communication between the mobile device and the onboard apparatus. The mobile device and the onboard apparatus store the key, and perform the cryptographic communication using the key. The key issuing apparatus issues, to the onboard apparatus, the key and validity information indicating validity of the key. The onboard apparatus includes a determination section determining whether a validity ends, and an update request section transmitting a key update request to request the issuance of a new key. When the key update request has been received, the key issuing apparatus issues a new key to the mobile device, and issues a new key and validity information on the new key to the onboard apparatus.

Abstract: An impeller (100) for a fluid pump according to the present invention comprises a shroud (150) that has a disk shape and is drivingly rotated about a center axis, and a cover (110) comprising a cover main body (120) having a truncated cone shape with an inlet port (123) for a fluid formed at a center and a plurality of blades (130) arranged around a center axis of the cover main body (120). The cover (110) and the shroud (150) are joined to each other with a welding contacting portion (135) and a welding contacted portion (177) welded to each other in a center axis direction, in a state where another end surface of the shroud (150) and a distal end portion (131) of the blades (130) are in parallel with each other.

Abstract: A satisfactory oxygen storage material and a method for producing it are provided. The oxygen storage material comprises zirconia particles with a ceria-zirconia complex oxide supported on the zirconia particles. The ceria-zirconia complex oxide includes a pyrochlore phase and has a mean crystallite diameter of 10 nm to 22.9 nm.

Abstract: A production method comprising: adding a hydroxycarboxylic acid to an aqueous solution containing a Ce salt, a Zr salt, an Al salt, and at least one selected from a La salt, an Mg salt, and a Ca salt, to produce a gel, heating the gel to obtain a solid product by decomposition of the salts, firing the solid product to obtain a fired product containing a ceria-zirconia-based regular array phase precursor and an aluminate-based composite oxide precursor, performing a reducing heat treatment of the fired product to obtain a first composite having mutually dispersed therein a pyrochlore phase and an aluminate-based composite oxide, and performing an oxidizing heat treatment of the first composite to obtain a second composite in which at least part of the pyrochlore phase is transformed into a ? phase; and an oxygen storage material having mutually dispersed therein the composite oxide and the regular array phase.