Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

Abstract: Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

Abstract: Provided is a transdermal absorption sheet capable of improving strength against impact at the time of puncture. A transdermal absorption sheet includes a sheet portion and a plurality of needle-like protruding portions arranged on a first principal surface of the sheet portion, in which the sheet portion has a center portion which is a region in which the plurality of needle-like protruding portions are formed, and an outer edge portion which is a region from the center portion to an end portion, and a maximum thickness of a thickness portion of the outer edge portion is larger than an average thickness of the center portion.

Abstract: Provided is a method for producing a transdermal absorption sheet capable of suppressing the entrainment of bubbles in a liquid material. A method for producing a transdermal absorption sheet includes a step of preparing a mold having a plurality of needle-like recessed portions, and a step portion which surrounds the plurality of needle-like recessed portions and is higher than a needle-like recessed portion formed surface, and a step of supplying a liquid material for a transdermal absorption sheet from a jetting opening of a filling head to a region surrounded the step portion of the mold, in which the filling head includes a head main body having an inner wall surface defining a supply pipe, and the inner wall surface includes a tapered pipe surface defining a tapered pipe having a diameter gradually increased toward the jetting opening of the head main body.

Abstract: Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.

Abstract: The disclosed nanoimprinting method suppresses fluctuations in thickness of residual film and defects due to residual gas in a resist film, onto which a pattern of protrusions and recesses is transferred, in a nanoimprinting method that employs the ink jet method to coat a substrate with droplets of resist material. Droplets are coated onto a substrate such that the spaces between the droplets along an A direction which is substantially parallel to the direction of the lines of a linear pattern of protrusions and recesses are longer than the spaces between the droplets in a B direction which is substantially perpendicular to the A direction, in a nanoimprinting method that coats a substrate with the droplets of a resist material using the ink jet method.

Abstract: Provided is a manufacturing method of a sheet having needle-like protrusions capable of individually manufacturing sheets on a mold. The manufacturing method of a sheet having needle-like protrusions includes, for a mold provided with needle-like recesses and an annular groove provided around a region where the needle-like recesses are formed, a first polymer solution supplying step of supplying a first polymer solution, which is to become a first layer, to the needle-like recesses; a second polymer solution supplying step of filling the needle-like recesses and the groove with a second polymer solution by supplying the second polymer solution, which is to become a second layer, to a surface of the mold; a drying step of forming a laminate of the first layer and the second layer by drying the first polymer solution and the second polymer solution; and a peeling step of peeling the laminate away from the mold.

Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.

Abstract: To provide a transdermal absorption sheet with which control of a dissolution rate and suppression of drug diffusion can be achieved, and a method of manufacturing the transdermal absorption sheet. A transdermal absorption sheet 100 is provided with a sheet portion 116, a plurality of frustum portions 114 that is disposed on the sheet portion 116, and needle portions 112 that are disposed on the frustum portions 114, each of the plurality of needle portions 112 includes a first layer 120 containing a drug and a second layer 122 not containing a drug, and at least one of the plurality of needle portions 112 contains an air bubble 124.

Abstract: Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.

Abstract: Provided is a transdermal absorption sheet capable of improving strength against impact at the time of puncture. A transdermal absorption sheet includes a sheet portion and a plurality of needle-like protruding portions arranged on a first principal surface of the sheet portion, in which the sheet portion has a center portion which is a region in which the plurality of needle-like protruding portions are formed, and an outer edge portion which is a region from the center portion to an end portion, and a maximum thickness of a thickness portion of the outer edge portion is larger than an average thickness of the center portion.

Abstract: The disclosed nanoimprinting method suppresses fluctuations in thickness of residual film and defects due to residual gas in a resist film, onto which a pattern of protrusions and recesses is transferred, in a nanoimprinting method that employs the ink jet method to coat a substrate with droplets of resist material. Droplets are coated onto a substrate such that the spaces between the droplets along an A direction which is substantially parallel to the direction of the lines of a linear pattern of protrusions and recesses are longer than the spaces between the droplets in a B direction which is substantially perpendicular to the A direction, in a nanoimprinting method that coats a substrate with the droplets of a resist material using the ink jet method.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.

Abstract: Provided are a transdermal absorption sheet capable of suppressing a sheet portion from being curled and of improving impact resistance of the sheet portion, and a method of manufacturing the transdermal absorption sheet, capable of suppressing a sheet portion from being curled in drying and of shortening a time required for drying a base material liquid. A transdermal absorption sheet includes: a sheet portion; a plurality of needle-like protruding portions that are arranged on one surface of the sheet portion; and a sheet-like mesh structure body that is included in the sheet portion and that has an area, in a plan view, including at least a part of a region in which the plurality of needle-like protruding portions are arranged.