Patents by Inventor Satsuki Okuyama

Satsuki Okuyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pradimic acids, amides, and pradimicin derivatives
    Patent number: 5608044
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl.The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: March 4, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Pradimic acids, amides, and novel pradimicin derivatives
    Patent number: 5414073
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: May 9, 1995
    Assignee: Bristol-Myers Squibb
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Pradimic acids, amides, and pradimicin derivatives
    Patent number: 5326867
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Pradimicin derivatives
    Patent number: 5227370
    Abstract: The present invention provides pradimicin analogs which exhibit improved water solubility relative to parent compounds. These novel agents are useful in treatment of fungal infections.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: July 13, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hajime Kamachi, Seiji Iimura, Satsuki Okuyama, Shimpei Aburaki, Takayuki Naito, Yasutsugu Ueda, Leonard B. Crast, Jr., Amarendra B. Mikkilineni
  • Process for cephem prodrug esters
    Patent number: 4935508
    Abstract: A process for the selective formation of oximino o-protected derivatives of lower alkyl 2-(2-aminothiazol-4-yl)-2-oximinoacetates, and their use in the acylation of 7-amino-cephalosporin compounds is disclosed.
    Type: Grant
    Filed: August 23, 1988
    Date of Patent: June 19, 1990
    Assignee: Bristol-Myers Company
    Inventors: Hajime Kamachi, Takaaki Okita, Satsuki Okuyama, Takayuki Naito