Patents by Inventor Saul A. Villeda

Saul A. Villeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating aging-associated cognitive impairment by reducing CCR3
    Patent number: 11912998
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: February 27, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • PLATELET FACTORS AND COGNITIVE IMPROVEMENT
    Publication number: 20230181691
    Abstract: Provided herein are Platelet Activating Factor 4 (PF4) polypeptide and other compositions and methods for improving cognitive function in an individual comprising treatment with PF4 and other polypeptides.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 15, 2023
    Applicant: The Regents of the University of California
    Inventors: Dena Dubal, Cana Park, Saul Villeda, Adam Schroer, Patrick Ventura
  • CCR3 MODULATION IN THE TREATMENT OF AGING-ASSOCIATED IMPAIRMENTS, AND COMPOSITIONS FOR PRACTICING THE SAME
    Publication number: 20220213487
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: December 14, 2021
    Publication date: July 7, 2022
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • EXERCISE-INDUCED CIRCULATORY FACTORS FOR AMELIORATION OF COGNITIVE, NEUROLOGICAL, AND REGENERATIVE DYSFUNCTION DURING AGING
    Publication number: 20220118060
    Abstract: Provided herein are glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1) polypeptide compositions and methods for improving cognitive function and/or motor impairment in an individual comprising treatment with a Gpld1 polypeptide.
    Type: Application
    Filed: February 4, 2020
    Publication date: April 21, 2022
    Inventors: Saul A. Villeda, Alana Horowitz, Xuelai Fan
  • Method of reducing the effects of aging-associated impairment of neurogenesis comprising modulating c-c chemokine receptor type 3 (CCR3)
    Patent number: 11236340
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: February 1, 2022
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • METHODS FOR SCREENING HUMAN BLOOD PRODUCTS COMPRISING PLASMA USING IMMUNOCOMPROMISED RODENT MODELS
    Publication number: 20210236656
    Abstract: Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory.
    Type: Application
    Filed: January 20, 2021
    Publication date: August 5, 2021
    Inventors: Steven Braithwaite, Saul A. Villeda, Anton Wyss-Coray
  • Methods for screening human blood products comprising plasma using immunocompromised rodent models
    Patent number: 10905779
    Abstract: Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: February 2, 2021
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, ALKAHEST, INC.
    Inventors: Steven Braithwaite, Saul A. Villeda, Anton Wyss-Coray
  • CCR3 MODULATION IN THE TREATMENT OF AGING-ASSOCIATED IMPAIRMENTS, AND COMPOSITIONS FOR PRACTICING THE SAME
    Publication number: 20200399644
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: April 7, 2020
    Publication date: December 24, 2020
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED CONDITIONS
    Publication number: 20200352994
    Abstract: Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 12, 2020
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Joseph M. Castellano, Jinte Middeldorp, Martin S. Angst, Jian Luo
  • Methods and compositions for treating aging-associated conditions
    Patent number: 10688130
    Abstract: Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 23, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Joseph M. Castellano, Jinte Middeldorp, Martin S. Angst, Jian Luo
  • Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
    Patent number: 10626399
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: April 21, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Methods and compositions for treating aging-associated impairments
    Patent number: 10487148
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: November 26, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ALKAHEST, INC.
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • CCR3 MODULATION IN THE TREATMENT OF AGING-ASSOCIATED IMPAIRMENTS, AND COMPOSITIONS FOR PRACTICING THE SAME
    Publication number: 20190185862
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: January 6, 2017
    Publication date: June 20, 2019
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS
    Publication number: 20190106495
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the ?2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: October 23, 2018
    Publication date: April 11, 2019
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • CCR3 MODULATION IN THE TREATMENT OF AGING-ASSOCIATED IMPAIRMENTS, AND COMPOSITIONS FOR PRACTICING THE SAME
    Publication number: 20190024091
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 24, 2019
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS
    Publication number: 20180298102
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Application
    Filed: May 17, 2016
    Publication date: October 18, 2018
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Karoly Nikolich
  • METHODS FOR SCREENING HUMAN BLOOD PRODUCTS COMPRISING PLASMA USING IMMUNOCOMPROMISED RODENT MODELS
    Publication number: 20170232118
    Abstract: Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory.
    Type: Application
    Filed: May 2, 2017
    Publication date: August 17, 2017
    Inventors: Steven Braithwaite, Saul A. Villeda, Anton Wyss-Coray
  • METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED CONDITIONS
    Publication number: 20150157664
    Abstract: Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Inventors: Anton Wyss-Coray, Saul A. Villeda, Joseph M. Castellano, Jinte Middeldorp, Martin S. Angst, Jian Luo