Patents by Inventor Sayaka Asari
Sayaka Asari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11680279Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.Type: GrantFiled: November 26, 2018Date of Patent: June 20, 2023Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Rekha Murali, Sayaka Asari, Keita Fukui, Miku Toyazaki, Keiko Noguchi
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Patent number: 11053519Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.Type: GrantFiled: April 24, 2019Date of Patent: July 6, 2021Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Keita Fukui, Miku Toyazaki
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Patent number: 10876138Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of enolase is reduced.Type: GrantFiled: April 24, 2019Date of Patent: December 29, 2020Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Sayaka Asari, Miku Toyazaki, Keita Fukui
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Patent number: 10858676Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.Type: GrantFiled: May 17, 2018Date of Patent: December 8, 2020Assignee: AJINOMOTO CO., INC.Inventors: Christine Roche, Benjamin Mijts, Peter Kelly, Matthew Davis, Sayaka Asari, Keita Fukui, Miku Toyazaki
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Patent number: 10808264Abstract: A method for producing benzaldehyde is provided. Benzaldehyde is produced from L-phenylalanine or a carbon source by using microorganism(s) having amino acid deaminase, 4-hydroxymandelate synthase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase.Type: GrantFiled: July 11, 2018Date of Patent: October 20, 2020Assignee: AJINOMOTO CO., INC.Inventors: Yasuaki Takakura, Keiko Danjo, Keita Fukui, Sayaka Asari, Takuto Ono
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Publication number: 20190249205Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of an L-cysteine biosynthesis enzyme is increased.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Keita Fukui, Miku Toyazaki
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Publication number: 20190249206Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of enolase is reduced.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Sayaka Asari, Miku Toyazaki, Keita Fukui
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Publication number: 20190241915Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.Type: ApplicationFiled: April 24, 2019Publication date: August 8, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Keita Fukui, Miya Toyazaki
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Publication number: 20190241914Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of NCgl2048 protein is reduced.Type: ApplicationFiled: April 24, 2019Publication date: August 8, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Miku Toyazaki, Keita Fukui
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Publication number: 20190161776Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.Type: ApplicationFiled: November 26, 2018Publication date: May 30, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Rekha Murali, Sayaka Asari, Keita Fukui, Miku Toyazaki, Keiko Noguchi
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Publication number: 20180334693Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.Type: ApplicationFiled: May 17, 2018Publication date: November 22, 2018Applicant: AJINOMOTO CO., INC.Inventors: Christine Roche, Benjamin Mijts, Peter Kelly, Matthew Davis, Sayaka Asari, Keita Fukui, Miku Toyazaki
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Publication number: 20180312881Abstract: A method for producing benzaldehyde is provided. Benzaldehyde is produced from L-phenylalanine or a carbon source by using microorganism(s) having amino acid deaminase, 4-hydroxymandelate synthase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase.Type: ApplicationFiled: July 11, 2018Publication date: November 1, 2018Applicant: AJINOMOTO CO., INC.Inventors: Yasuaki Takakura, Keiko Danjo, Keita Fukui, Sayaka Asari, Takuto Ono
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Patent number: 9562043Abstract: The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatment of diseases involving TRPA1. A medicament containing a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and the like.Type: GrantFiled: July 16, 2014Date of Patent: February 7, 2017Assignee: EA PHARMA CO., LTD.Inventors: Tamotsu Suzuki, Kaori Kobayashi, Sayaka Asari, Seiji Shiraishi, Tatsuya Okuzumi
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Patent number: 9174932Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.Type: GrantFiled: March 28, 2014Date of Patent: November 3, 2015Assignee: AJINOMOTO CO., INC.Inventors: Masayuki Sugiki, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
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Publication number: 20140329796Abstract: The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatment of diseases involving TRPA1. A medicament containing a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and the like.Type: ApplicationFiled: July 16, 2014Publication date: November 6, 2014Applicant: Ajinomoto Co., Inc.Inventors: Tamotsu SUZUKI, Kaori Kobayashi, Sayaka Asari, Seiji Shiraishi, Tatsuya Okuzumi
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Publication number: 20140303122Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: March 28, 2014Publication date: October 9, 2014Applicant: AJINOMOTO CO., INC.Inventors: Masayuki SUGIKI, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
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Patent number: 8796485Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 4, 2011Date of Patent: August 5, 2014Assignee: Ajinomoto Co., Inc.Inventors: Masayuki Sugiki, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
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Publication number: 20130041000Abstract: Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.Type: ApplicationFiled: August 14, 2012Publication date: February 14, 2013Applicant: AJINOMOTO CO., INC.Inventors: Takashi YAMAMOTO, Akira Chiba, Koichi Fujita, Yuka Kataba, Koji Ohsumi, Sayaka Asari, Naoyuki Fukuchi, Misato Noguchi, Itsuya Tanabe, Chiori Ijichi, Naoko Oomuta, Yuko Iida, Satoshi Iwayama
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Publication number: 20110251418Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 4, 2011Publication date: October 13, 2011Applicant: AJINOMOTO CO., INC.Inventors: Masayuki Sugiki, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
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Patent number: 7683077Abstract: The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7.Type: GrantFiled: May 19, 2004Date of Patent: March 23, 2010Assignee: Ajinomoto Co., Inc.Inventors: Shingo Makino, Naoyuki Fukuchi, Sayaka Asari, Masaki Hashimoto, Tetsuo Yano, Youji Yamada, Munetaka Tokumasu, Masataka Shoji, Itsuya Tanabe, Shinichi Fujita, Hideki Matsumoto