Patents by Inventor Sayan Mondal

Sayan Mondal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TYK2 inhibitors and uses thereof
    Patent number: 11174265
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: November 16, 2021
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit De Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20210230163
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: May 4, 2020
    Publication date: July 29, 2021
    Inventors: Jeremy Robert GREENWOOD, Geraldine C. HARRIMAN, Silvana Marcel LEIT DE MORADEI, Craig E. MASSE, Thomas H. MCLEAN, Sayan MONDAL
  • METHODS FOR PREDICTING AN ACTIVE SET OF COMPOUNDS HAVING ALTERNATIVE CORES, AND DRUG DISCOVERY METHODS INVOLVING THE SAME
    Publication number: 20210217500
    Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.
    Type: Application
    Filed: October 18, 2018
    Publication date: July 15, 2021
    Inventors: Robert L. Abel, Lingle Wang, Sathesh Bhat, Sayan Mondal, Jeremy Robert Greenwood, Kyle Konze
  • TYK2 inhibitors and uses thereof
    Patent number: 11046698
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: June 29, 2021
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20210094948
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: February 28, 2020
    Publication date: April 1, 2021
    Inventors: Jeremy Robert Greenwood, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20210047319
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: July 24, 2020
    Publication date: February 18, 2021
    Inventors: Craig E. MASSE, Jeremy Robert GREENWOOD, Donna L. ROMERO, Geraldine C. HARRIMAN, Ronald T. WESTER, Mee SHELLEY, Joshua Jahmil KENNEDY-SMITH, Markus DAHLGREN, Sayan MONDAL, Shaughnessy ROBINSON
  • TYK2 inhibitors and uses thereof
    Patent number: 10793574
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: October 6, 2020
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 inhibitors and uses thereof
    Patent number: 10781204
    Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: September 22, 2020
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Donna L. Romero, Geraldine C. Harriman, Ronald T. Wester, Mee Shelley, Joshua Jahmil Kennedy-Smith, Markus Dahlgren, Sayan Mondal, Shaughnessy Robinson
  • Physics-based computational methods for predicting compound solubility
    Patent number: 10783985
    Abstract: Methods of calculating a free energy of solubility for a compound in a solvent by computer operations include the following steps: (i) establishing, using a computer model, an initial state for a system including an aggregate of multiple molecules of the compound in a solvent; (ii) establishing, using the computer model, a final state of the system including a single molecule from the aggregate fully solvated in the solvent and separate from a transformed aggregate; (iii) transforming, using the computer model, the system from the initial state to the final state, via removing a first molecule of the compound from the aggregate to form the transformed aggregate and replacing the first molecule with solvent at the site of the first molecule; and (iv) calculating the free energy of the transformation between the initial and the final states, which determines the free energy of solubility for the compound.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: September 22, 2020
    Assignee: Schrödinger, LLC
    Inventors: Sayan Mondal, Robert L. Abel
  • TYK2 inhibitors and uses thereof
    Patent number: 10647713
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 12, 2020
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20200131201
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: October 15, 2019
    Publication date: April 30, 2020
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • TYK2 inhibitors and uses thereof
    Patent number: 10577373
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: March 3, 2020
    Assignee: Nimbus Lakshimi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 10570145
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 25, 2020
    Assignee: Nimbus Lakshimi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 10562906
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 18, 2020
    Assignee: Nimbus Lakshimi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 10562907
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 18, 2020
    Assignee: Nimbus Lakshimi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 10508120
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: December 17, 2019
    Assignee: Nimbus Lakshimi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20190284194
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: April 30, 2019
    Publication date: September 19, 2019
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20190256519
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 22, 2019
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20190248797
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 15, 2019
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20190241577
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 8, 2019
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean